@Tcomplex

Professor of Genetics at Cornell and Avid Golfer

 Ithaca, NY
schimentilab.org
Joined July 2009
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  • Followers413
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A terrific body of work by postdoc Munisha Mumingjiang and grad student Rui Huang on the impact of genomic instability on trophoblast stem cells and placenta development. Years in the making. biorxiv.org/content/10.1101/…

Chronic replication stress-mediated genomic instability disrupts placenta development in mice

Abnormal placentation drives many pregnancy-related pathologies and poor fetal outcomes, but the underlying molecular causes are understudied. Here, we show that persistent replication stress due to...

biorxiv.org
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Replying to @jaygirimd @epler_john @NIH @petegroen @djc795 @adnanalkhouli @PennCardiology @CMichaelGibson @PennLDI
A few decades ago, I remember writing in a % of admin salaries (say, a Departmental staffer) on my grants (part of DC). I guess rule changes since then pushed those all into IDC.
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A high throughput CRISPR perturbation screen identifies epigenetic regulators impacting primordial germ cell development biorxiv.org/content/10.1101/… We found that a histone deacetylase KD, and HDAC inhibitors (inc. a dietary supplement), impede PGCLC formation> somatic genes stay on

A high throughput CRISPR perturbation screen identifies epigenetic regulators impacting primordial...

Certain environmental factors can impact fertility and reproductive parameters such as the number and quality of sperm and eggs. One possible mechanism is the perturbation of epigenetic landscapes in...

biorxiv.org
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Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells biorxiv.org/content/10.1101/… If you need a ton of PGCLCs and don't want to use expensive cytokines in the process, you may find this method useful.

Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells

Primordial germ cells (PGCs) are the founder cells of the germline. The ability to generate PGC-like cells (PGCLCs) from pluripotent stem cells has advanced our knowledge of gametogenesis and holds...

biorxiv.org
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Replying to @Cryptocito
Thanks Cito for you great content! Been following you for a couple of years on YouTube, and as a result I too have focussed most of my Crupto interest on the Cosmos.
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1 y.o. grand-daughter figures out how to make every putt!
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Our studies of why genetic variant pathogenicity prediction algorithms leave much to be desired: pnas.org/doi/10.1073/pnas.22…

In vivo versus in silico assessment of potentially pathogenic missense variants in human reproduc...

Infertility is a heterogeneous condition, with genetic causes thought to underlie a substantial fraction of cases. Genome sequencing is becoming in...

pnas.org
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Replying to @CorcesVictor
There's a series of (dubious?) papers on "sperm mediated gene transfer." For example: Cell 1989 doi: 10.1016/0092-8674(89)90787-3. Wonder if fragments of epididymal DNA carried by sperm ever integrate into fertilized egg?
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Junior faculty positions at Cornell in reproduction!
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Meet NYSCF – Druckenmiller Fellow @MominMunisa, #postdoc in the @Tcomplex lab @Cornell! Munisha studies the genetics behind #placenta development to help prevent #preeclampsia & #pregnancyloss: bit.ly/3TMMMqx #PostdocAppreciationWeek #PostdocAppreciation #WomeninSTEM
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Replying to @Tesla
Maybe your card? Possibly the 12V battery died. Tesla should be able to diagnose remotely.
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Come join us tomorrow! If it adds validity to my resume, My partner @turk727 and I won the @NYSGA1923 4-ball today at Leatherstocking GC. Shout out to @oneillrida92 and staff for a championship venue this week!
Micah Woods@micahwoodsturf23 May 2022
In the next ATC Office Hours (Tuesday, May 24, check your time zone), @Carl_Schimenti joins for a discussion of golf course playability and the maintenance work needed to produce the best conditions. youtu.be/2fMhNSEkpLI
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Replying to @SHAQ @solana
Terry Magnuson
Replying to @vera_rinaldi
Great work you two! Vera is indeed a force of nature. I loved having her in the lab...her passion for science is unparalleled.
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John Schimenti retweeted
Cornell University
@Cornell7 Nov 2021
CornellALERT: EVACUATE AND AVOID THE LAW SCHOOL,GOLDWIN SMITH, UPSON HALL AND KENNEDY HALL PLEASE DO NOT CALL THE CORNELL POLICE UNLESS YOU HAVE AN EMERGENCY
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Replying to @GenomeStability
Yup, and the cost! But there's no substitute for functional studies.
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A firehose of variants, a few drops of validation.... biorxiv.org/content/10.1101/…

In vivo versus in silico assessment of potentially pathogenic missense variants in human reproduc...

Infertility is a highly heterogeneous condition, with genetic causes estimated to be involved in approximately half of the cases. High-throughput sequencing (HTS) approaches are becoming an increas...

biorxiv.org
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John Schimenti retweeted
Cornell MBG@CornellMBG29 Sep 2021
Super excited to announce that MBG is searching for TWO new faculty members! Open topic - we're happy to receive applications from biologists working in any research area that spans the breadth of MBG. academicjobsonline.org/ajo/j…
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Quote from Tom Brady on getting older: “You think people care what you think, and then you care less what people think, and then you realize no one cared, anyway.”
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Our 2021 #NYSMensMidAm champion 🏆 Carl Schimenti (Cornell University GC) outlasted Chris Blyth (Locust Hill CC) in a two-hole playoff to win his first NYS title! Recap: bit.ly/3EW2pVe
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