@TempChiao_

Tempchiao

 Edinburgh, Scotland
Joined October 2017
  • Tweets19
  • Following55
  • Followers9
TempChiao retweeted
thmonk@thmonk_pf4 Mar 2025
Alzheimer病初期には大脳皮質/海馬の神経過興奮が特徴的に見られ疾患の進行と共に活動低下に移行する この過興奮性はCa++ homeostasis破綻/glutamate signal異常/Aβ・tau病理/APOE4の影響/glia機能障害など複数の機構が関与 OA #hyperexcitability #Alzheimers #papers doi.org/10.1038/s41398-022-0…
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凄い！！！ ｢ハエの史上最大の脳地図｣ Nature News ･ 約14万個のニューロン間の接続を表現 ･ 神経細胞間の接続であるシナプスが5450万個以上記録 ･ 電子顕微鏡画像を使用して、4年以上にわたって地図を開発 ･ 手作業でデータの校正に多大な時間を費やした nature.com/articles/d41586-0…
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Migraine is a common, chronic disorder that is typically characterized by recurrent disabling attacks of headache and accompanying symptoms, including aura. go.nature.com/3zUcVtS #MigraineAwarenessWeek
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TempChiao retweeted
ESMB@EdBiophysics8 Aug 2024
Sad to see Dylan leave us, but we wish him luck in his new role @micrographiaBio!
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Birth of a neuron. Stem cell transforming into a brain cell
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Short summary thread of our recent review on de novo protein design: (Poster-sized figure (36 x 48 inches) for printing: drive.google.com/file/d/1sG3…)
Nature Biotechnology
@NatureBiotech21 Feb 2024
Sparks of function by de novo protein design go.nature.com/48jXz1z
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A beautiful and important paper!
Wai Keen Vong@wkvong1 Feb 2024
1/ Today in Science, we train a neural net from scratch through the eyes and ears of one child. The model learns to map words to visual referents, showing how grounded language learning from just one child's perspective is possible with today's AI tools. science.org/doi/10.1126/scie…
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Chronic imaging of neuronal activity in the somatosensory cortex, in response to self motivated exploratory locomotion in an awake behaving mouse. rdcu.be/dtg4p
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In the quest for low phototoxicity, light dosage is key. Molecular actinometers based on dyes and fluorescent proteins enable precise measurements of photons delivered at the sample in light microscopes. nature.com/articles/s41592-0…

Fluorescence to measure light intensity

Nature Methods - Two methods for fluorescence-based actinometry using organic dyes and photoconvertible fluorescent proteins enable rapid and precise measurement of light intensity at the sample in...

nature.com
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Check out the latest in #DeepLearning-based image denoising for #Fluorescence #Microscopy! DeepSeMi is a self-supervised method demonstrated for extended multicolor #LiveCell #Imaging in Dictyostelium cells. Learn more: nature.com/articles/s41592-0…
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We're back to a regular issue this week with lots of great content: cell.com/neuron/current Kaibin Wu & Feixue Liang created the cover for their paper on the cingulate cortex encoding safety assessment and mediating flexibility of fear reactions (cell.com/neuron/fulltext/S08…).
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𝗗𝗼𝘄𝗻 𝘄𝗶𝘁𝗵 𝗰𝗼𝗿𝘁𝗶𝗰𝗼-𝗰𝗲𝗻𝘁𝗿𝗶𝘀𝗺! How deep is the brain? The shallow brain hypothesis nature.com/articles/s41583-0…
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TempChiao retweeted
nature
@Nature24 Oct 2023
Anti-COVID drug Molnupiravir accelerates viral evolution go.nature.com/46JyZXI
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The chemistry of next-generation sequencing go.nature.com/46LXALP
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CRISPR-Cas13 is tremendously useful for targeting, detecting, imaging, and editing RNA - but we know very little about how it can target structured RNAs, which predominate in nature. (1/19)
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A study finds neurons stochastically generated up to eight different versions of a protein-regulating neurotransmitter release, which could vary how they communicate with other cells. mitsha.re/el5b50PRbF2
On a black background, three panels show a branch of a neuron where there is a thick main part and a thinner protrusion lined with little bulbs. The leftmost panel shows a gray main part with a somewhat yellow protrusion. The middle shows a grey thin part with a very yellow protrusion. In the right panel everything is very yellow.

ALT On a black background, three panels show a branch of a neuron where there is a thick main part and a thinner protrusion lined with little bulbs. The leftmost panel shows a gray main part with a somewhat yellow protrusion. The middle shows a grey thin part with a very yellow protrusion. In the right panel everything is very yellow.

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A new light sheet microscope for long-term live imaging of organoids, hydras… at a single cell resolution. Open top, dual view, dual illumination , compatible with multiwell plates. Moss et al. @priscaliberali @TweetPetrStrnad @ViventisMicro dlvr.it/Swnqmw
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Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD, Nature Structural & Molecular Biology 2023 rdcu.be/dngWE thanks to Ernest Laue @BDH_LabE. @srinjan_basu, @KlenermanLab and B. D hendrich for an amazing collaboration
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