Engineering innate immunity // Host-pathogen interactions // Systems Biology // Tuberculosis @MIT @MITDeptOfBE
Boston, MA
Joined September 2017
- Tweets819
- Following2.3K
- Followers3.5K
- Likes1.9K
Anyone in my science network have experience with producing soluble TCRs? Better yet affinity maturation of TCRs?
Anyone in the de novo minibinder design space using their binders as flow cytometry staining reagents? Would love to compare notes if so!
Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: biorxiv.org/cgi/content/shor…
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/8…
We're excited! This study supports the concept that there are multiple ways to transfer proteins from the phagosome to the cytosol, and that Mtb specifically takes advantage of this.
Thanks to our many collaborators at the @ragoninstitute and across the broader community and our funders #tuberculosis
Congrats especially to Owen and Rachel, the two fearless graduate students who led this work -- y'all are the best <3
Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): biorxiv.org/content/10.1101/…
We think this work is important because:
1. It helps us think about species differences in new ways
2. It highlights a metabolic gate in Mtb-host interactions
3. It may help resolve long-standing challenges in translating concepts from mouse studies to humans