@TheHomemLab
 Lisbon, Portugal
authors.elsevier.com/sd/article/S0012-1606(23)00140-9
Joined March 2015
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Open position for a research assistant/PhD student to work in metabolic and transcriptional regulation of stem cells in Drosophila! Check out more at euraxess.pt/jobs/295466
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Interested in doing your PhD in Lisbon, working in neurodevelopment and Drosophila? Our group is looking for candidates to apply for a FCT PhD fellowship! See below for more info and visit our group's page at tinyurl.com/4yf8jh9y. Repost appreciated!
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#DBfeature #Drosophila🪰 Opposing effects of ecdysone signaling regulate neuroblast proliferation to ensure coordination of brain and organism development by Andreia Oliveira, Catarina Homem @TheHomemLab sciencedirect.com/science/ar…
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Our latest article is out ! read it here👇 authors.elsevier.com/sd/arti…
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Do you know how animals coordinate the growth of their different organs during development? Systemic signals such as hormones coordinate the development of all organs and direct tissue specific developmental programs.
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In our latest article we demonstrate that Drosophila brain development is under the coordination of the hormone ecdysone. We show that neuroblasts have an intrinsic capacity to proliferate indefinitely and require ecdysone signalling to determine cell cycle pace!
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Catarina Homem retweeted
FocalPlane@focalplane_jcs9 Jun 2023
Happy #FluorescenceFriday! Eunice Silva, @margarida_venda & @TheHomemLab find that serine hydroxymethyl transferase is required for optic lobe neuroepithelia development in Drosophila. 📖@Dev_Journal: journals.biologists.com/dev/… #DevSImetabolism
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Catarina Homem retweeted
Development@Dev_journal8 Jun 2023
Serine hydroxymethyl transferase is required for optic lobe neuroepithelia development in Drosophila An #OpenAccess Research Article in our Stem Cells and Regeneration section of #DevSImetabolism by Eunice Silva, @margarida_venda & @TheHomemLab journals.biologists.com/dev/…
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Our latest article is out ! read it here👇 journals.plos.org/plosbiolog…

Asynchronous transcription and translation of neurotransmitter-related genes characterize the...

Within hours of neuron birth, terminal differentiation genes (e.g. neurotransmitter-related genes) are transcribed, but not translated. This study in Drosophila reveals that these transcripts are...

journals.plos.org
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In our brand-new article in @PLOSBiology we use Drosophila to show that the transcription and translation of neurotransmitter-associated genes is timely coordinated with the animal’s development.
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According to our model, the onset of translation is delayed in order to regulate neuronal maturation. Learn more by checking the link in our bio!
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Catarina Homem retweeted
PLOS Biology@PLOSBiology23 May 2023
Within hours of #neuron birth, terminal differentiation genes are transcribed, but not translated. In #PLOSBiology, @TheHomemLab reveals that these transcripts are only translated days later in a way that coordinates with developmental stage in #Drosophila plos.io/3IzWad5
A fluorescence microscopy image showing VGlut expression in the optic lobe of a wild-type Drosophila larva at 48h after puparium formation. Credit: Graça S. Marques

ALT A fluorescence microscopy image showing VGlut expression in the optic lobe of a wild-type Drosophila larva at 48h after puparium formation. Credit: Graça S. Marques

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Our postdoc Ana just signed her CEEC contract, granting her funds to pursue her scientific work for the next 6 years! Congrats ! @nova_medschool @fct_pt @NOVAunl
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Check-out our new paper! Serine hydroxymethyl transferase (Shmt) is required for optic lobe neuroepithelia development in Drosophila. tinyurl.com/2rwmrrm8
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These defects are similar to the defects that are observed when neural tube closure defects occur in human fetuses, and sets important foundations to understand how folic acid works during brain formation.
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@ERC_Research @HHMINEWS @EMBO @fct_pt @nova_medschool #basicbiology #development #drosophila #metabolism #neurodevelopment
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Check out our newest open-access paper on dMyc-dependent upregulation of heterodimeric amino acid transporters and their role in Drosophila brain tumor growth! link.springer.com/article/10…

dMyc-dependent upregulation of CD98 amino acid transporters is required for Drosophila brain tumor...

Cellular and Molecular Life Sciences - Tumor cells have an increased demand for nutrients to sustain their growth, but how these increased metabolic needs are ensured or how this influences tumor...

link.springer.com
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Interestingly, we show that the oncogene dMyc is involved in the upregulation of these transporters, highlighting the important link between oncogenes and metabolic transporters in the regulation of tumor growth.
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@ERC_Research @HHMINEWS @EMBO @fct_pt @nova_medschool #basicbiology #CancerResearch #drosophila
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