@TheJaeLab

Functional genomics lab at the LMU Gene Center in Munich, Germany. -Posts by LJ

genzentrum.uni-muenchen.de/research-groups/jae/index.html
Joined February 2020
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  • Following251
  • Followers480
5Media
Check out our new @Nature paper showing that heme scarcity is surprisingly sensed in #mitochondria by the #DELE1 pathway. Conserved all the way to Hydra, this ancient system takes the heme reading in the very organelle that produces this key metabolite. nature.com/articles/s41586-0…

An ancient mitochondrial program tunes translation to haem availability

Nature - An evolutionarily conserved mitochondrial haem-sensing mechanism that predates the emergence of haemoglobin-based oxygen transport could have therapeutic value in iron deficiency disorders.

nature.com
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Spearheaded by @XiangZh04660352 and Max-Hinderk Schuler here at @GeneCenter_LMU @LMU_Muenchen, with fantastic collaborators: team @PichlmairL and Barbara Steigenberger @MPI_Biochem. Deeply grateful to our funders @ERC_Research, @dfg_public, Krupp Foundation and Vallee Foundation.
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If you’re into heme, also check out this intriguing study by our friends @Riemerlab on the spatial choreography of a key step in heme synthesis, also featuring an evolutionary plot twist: science.org/doi/10.1126/scia…

ALR couples IMS redox and heme biosynthesis beyond the disulfide relay

CPOX is a direct substrate of the mitochondrial oxidase ALR, linking intermembrane space redox chemistry to heme biosynthesis.

science.org
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Our joint study with Takaki Komiyama @takaki_komiyama is out in @Nature ! nature.com/articles/s41586-0… We found cell type-specific changes in the cortical circuit of Huntington’s disease mice. Optogenetic stimulation of VIP cells rescued circuit defects and improved motor function.

Restoring cortical disinhibition improves Huntington’s disease phenotypes

Nature - In a mouse model of Huntington’s disease, targeted modulation of neuronal activity restores network function and improves motor deficits.

nature.com
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📢 We are hiring! My lab is looking for a postdoctoral researcher. If you are excited about understanding cholesterol transport between the endoplasmic reticulum and mitochondria, membrane biology, lipid metabolism, or super-resolution imaging, please apply by June 30th!
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Big news this week: results of a very competitive @ERC_Research CoG call are in, and I’m happy that our project mitoSCALES (scales of mitochondrial stress response) is among the ~11% funded. Recruiting will begin soon—get in touch if you want to hop on board for the ride! #ERCCoG
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📣Only three weeks left to apply! Exciting projects with renowned scientists are available. Don’t miss your chance! qbm.genzentrum.lmu.de/applic… @TheJaeLab @karen_alim @PhysOfLifeLMU @hornung_lab @khmelinskaia @LFMilles @SchwilleLab @RaedlerLab @BenediktSabass
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Having a hard time with #CRISPR HDR? Your cells might be fighting against you! TREX1 nuclease, high in some cells, eats up HDR donor templates. Check out our paper in @NatureBiotech for the story & ways to improve HDR. nature.com/articles/s41587-0… With @karasuerman1 & @J_Maciejowski
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🥳🚨Paper Alert🚨🥳 Excited to present our latest work on #Opa1 in this newly published paper @ScienceAdvances by @sahola6 and @LPazurek. We present here two new mouse models with impaired Opa1 processing. 1/🧵 science.org/doi/10.1126/scia… #mitochondria #mitochondrialdynamics @MPIAGE

Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyop...

Inhibition of Opa1 processing in mice allows normal development but exacerbates mitochondrial cardiomyopathy.

science.org
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Don’t miss this great opportunity! Deadline is September 13.
QMB Munich@MunichQbm5 Aug 2024
🚀Wanna do your PhD at QMB? Apply NOW! Engage in interdisciplinary research that integrates experimental and theoretical approaches, or focus solely on theoretical work, and become a leader in the emerging field of quantitative, systems-oriented bioscience.qbm.genzentrum.lmu.de/applic…
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🚀Our celebratory symposium last Monday was enjoyed by all participants😀😆. Bavarian Minister of State Blume and LMU President Huber offered their congratulations. Patrick Cramer, President of the Max Planck Society, sent his greetings via video message.
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There is a new study section @GBM_eV @JuniorGBM on Organelle Biology and I have just joined - exciting initiative by @winklhofer_lab & @Herrmann_lab and very relevant for our new @dfg_public Priority Program
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Excited to share our latest study in @ImmunityCP showing how PLD exonucleases together with RNase T2 process RNA upstream of TLR7. ✂️🧬 Kudos to @BeroutiMarleen for her fantastic work! cell.com/immunity/fulltext/S…

Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7...

TLR7 is critical for recognizing RNA virus infection and initiating antiviral responses. Bérouti et al. demonstrate how RNase T2 and PLD exonucleases generate RNA fragments for TLR7 activation, thus...

cell.com
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Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s41586-0… rdcu.be/dBUju

Proteome-scale discovery of protein degradation and stabilization effectors

Nature - A synthetic proteome-scale strategy enables the identification of a diverse range of human proteins that can induce the degradation or stabilization of a target protein in a...

nature.com
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Looking for a postdoc position to study epithelial tissue dynamics in Drosophila? New institute, interdisciplinary, international environment and very livable place @uni_muenster One week left to apply, see thenode.biologists.com/jobs/…
@luschnig.bsky.social@StefanLuschnig28 Dec 2023
We´re hiring! 2-year #postdoc position opening in my lab @uni_muenster to work on membrane trafficking and epithelial tissue dynamics in #Drosophila. For details, see shorturl.at/auBW4 @the_Node Please RT
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Let's do the right click! In chemical proteomics chemoselectivity of the CuAAC is crucial. Andreas Wiest in our group found that formation of the ubiquitous thiotriazole byproduct during the click reactions can be easily diminished: pubs.acs.org/doi/10.1021/jac…. Congratulations!
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📣📣📣Great opportunity for ambitious junior researchers🫵 We are looking for an Independent Group Leader in Nucleic Acid Research🧬 genzentrum.uni-muenchen.de/c… Please RT🙏 #ApplyNow #Career
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How does mitochondria sense and control their glutathione levels? Our new work @ScienceMagazine by a fantastic student @YuyangLiu1996 describing a redox metabolite sensing mechanism for mitochondria. @RockefellerUniv @TheMarkFdn science.org/doi/10.1126/scie…

Autoregulatory control of mitochondrial glutathione homeostasis

Blockage of an inner mitochondrial membrane protease stabilizes a glutathione transporter, enabling autoregulatory homeostasis.

science.org
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📢Don't miss this publication by the @hornung_lab Congratulations to all people involved👏🥳 β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4: Cell Reports cell.com/cell-reports/fullte… @LMU_Muenchen @237Crc @sfb_1403

β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4

Sun et al. identify myofibroblasts as the major cell type expressing RIPK3 in bile-duct-ligation-induced liver fibrosis. Profibrotic β1 integrin signaling functions as the upstream driver of RIPK3...

cell.com
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Jae Lab retweeted
Yi Fu@Yi__Fu12 Oct 2023
Do cells care if their mitochondrial DNA is broken? Yes! Excited to share my PhD work showing that a fraction of cells with breaks in their mtDNA recover healthy mitochondria using the integrated stress response.
Molecular Cell@MolecularCell12 Oct 2023
Online Now: Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis dlvr.it/SxMgD3
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