Uffe H. Mortensen's Lab (@UHMortensenLab) profile picture

Uffe H. Mortensen's Lab

@UHMortensenLab

The Eukaryotic Molecular Cell Biology Lab @DTUbioengineer @DTUtweet led by Prof. UH Mortensen.

 Lyngby-Taarbæk, Danmark
dtu.dk/english/service/phonebook/person?id=7241&tab=2&qt=dtupublicationquery
Joined May 2019
  • Tweets32
  • Following72
  • Followers197
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Photo by Uffe H. Mortensen's Lab (@UHMortensenLab)Photo by Uffe H. Mortensen's Lab (@UHMortensenLab)
Our #OpenAccess "CRI-SPA: a high-throughput method for systematic genetic editing of yeast libraries" paper is now available at @NAR_Open. 👇 doi.org/10.1093/nar/gkad656
Image from Uffe H. Mortensen's Lab (@UHMortensenLab)
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Black yeasts are efficient heterologous hosts for the production of a wide range of fungal polyketides doi.org/10.1038/s41589-026-0…
Image from Uffe H. Mortensen's Lab (@UHMortensenLab)
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Uffe H. Mortensen's Lab retweeted
Tomas Strucko (@tomas_strucko) profile picture
Tomas Strucko@tomas_struckoJan 20
New tool for filamentous fungi by @UHMortensenLab doi.org/10.1093/nar/gkaf1488 "RoCi—a single-step multi-copy integration system based on rolling-circle replication" 👇🍄🔧⚙️
RoCi—a single-step multi-copy integration system based on rolling-circle replication

RoCi—a single-step multi-copy integration system based on rolling-circle replication

Abstract. Fungi are often used as cell factories for homologous and heterologous production of enzymes and metabolites. To obtain high-yielding strains it

academic.oup.com
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Uffe H. Mortensen's Lab retweeted
Tomas Strucko (@tomas_strucko) profile picture
Tomas Strucko@tomas_strucko28 May 2025
Latest from @UHMortensenLab microbialcellfactories.biome…
Chaperone overexpression boosts heterologous small molecule production in Saccharomyces cerevisiae

Chaperone overexpression boosts heterologous small molecule production in Saccharomyces cerevisiae

Microbial Cell Factories - Chaperones play an important role in maintaining cellular proteostasis by mediating protein folding. As a result, chaperone overexpression has been widely used as a tool...

link.springer.com
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Uffe H. Mortensen's Lab retweeted
Tomas Strucko (@tomas_strucko) profile picture
Tomas Strucko@tomas_strucko17 Oct 2024
The key plasmids from our Pichia tools paper academic.oup.com/femsyr/arti… are now available @Addgene addgene.org/Uffe_Mortensen/ please share the news 🧑‍🔬🧬
Oligonucleotide-based CRISPR-Cas9 toolbox for efficient engineering of Komagataella phaffii

Oligonucleotide-based CRISPR-Cas9 toolbox for efficient engineering of Komagataella phaffii

A streamlined CRISPR-Cas9-based toolbox that improves the engineering process of Komagataella phaffii yeast by implementing short single-stranded DNA seque

academic.oup.com
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Our preprint "RoCi - A Single Step Multi-Copy Integration System Based on Rolling-Circle Replication" is online at @bioRxiv_synbio @biorxivpreprint doi.org/10.1101/2024.09.13.6…
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Our #OpenAccess oligonucleotide-based gene engineering toolbox for Pichia is now published in @FEMSmicro Yeast Research 👇doi.org/10.1093/femsyr/foae0…
Oligonucleotide-based CRISPR-Cas9 toolbox for efficient engineering of Komagataella phaffii

Oligonucleotide-based CRISPR-Cas9 toolbox for efficient engineering of Komagataella phaffii

A streamlined CRISPR-Cas9-based toolbox that improves the engineering process of Komagataella phaffii yeast by implementing short single-stranded DNA seque

academic.oup.com
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"Oligonucleotide-based CRISPR-Cas9 toolbox for efficient engineering of Komagataella phaffii" is now online @biorxivpreprint 👇
Tomas Strucko (@tomas_strucko) profile pictureTomas Strucko@tomas_strucko10 Dec 2023
Our pre-print introducing some useful tools for Pichia pastoris engineering is online. Take a look and spread to the relevant peers 👨‍🔬👩‍🔬🧫 biorxiv.org/content/10.1101/… @DTUbioengineer
Image from Tomas Strucko (@tomas_strucko)
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Uffe H. Mortensen's Lab retweeted
Nathan Lewis (@Nathan_E_Lewis) profile picture
Nathan Lewis@Nathan_E_Lewis6 Nov 2023
I'll be giving a seminar tomorrow at @DTUtweet as part of their Biotech Lifelong learning series. I'll be talking about 'Rethinking omics in cell line design and engineering'. Join in person or online if you're interested dtu.events/seminarseries
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CRI-SPA tool in combination with biosensor allows high-throughput genome-wide identification of targets that improve cis-cis-muconic acid production in yeast doi.org/10.1101/2023.08.30.5…
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Uffe H. Mortensen's Lab retweeted
Akos T. Kovacs (@EvolvedBiofilm) profile picture
Akos T. Kovacs@EvolvedBiofilm6 Jan 2023
Whole genome sequence characterization of Aspergillus terreus ATCC 20541 and genome comparison of the fungi A. terreus -in @SciReports -with @UHMortensenLab nature.com/articles/s41598-0…
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Check out this cool job in Denmark. Join us on the hunt for plastic degrading enzymes at @DTUbioengineer together with fellow Boy band members at Enzync @UHMortensenLab and Peter Westh.efzu.fa.em2.oraclecloud.com/…
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Check our in vivo DNA assembly toolbox for simple genetic engineering of filamentous fungi. We show construction of vectors, complex multipurpose gene-targeting substrates and constructs for #CRISPR based marker-free gene editing directly in fungi 👇 pubs.acs.org/doi/10.1021/acs…
A Versatile in Vivo DNA Assembly Toolbox for Fungal Strain Engineering

A Versatile in Vivo DNA Assembly Toolbox for Fungal Strain Engineering

Abstract. Efficient homologous recombination in baker’s yeast allows accurate fusion of DNA fragments via short identical sequence tags in vivo. Eliminatin

pubs.acs.org
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Happy to share our latest work, CRI-SPA – a mating based method for high-throughput genetic modification of yeast strain libraries! Many possible applications for #sysbio and #biotech. Thanks to all involved @DTUbioengineer @DTUBiosustain. See👇 biorxiv.org/content/10.1101/…
CRI-SPA – a mating based CRISPR-Cas9 assisted method for high-throughput genetic modification of...

CRI-SPA – a mating based CRISPR-Cas9 assisted method for high-throughput genetic modification of...

Biological functions are orchestrated by intricate networks of interacting genetic elements. Predicting the interaction landscape remains a challenge for systems biology and the identification of...

biorxiv.org
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Really looking forward to this exciting collaboration!
Jens Preben Morth 🇪🇺 🇩🇰 🐾 🌍 (@Jpmorth) profile pictureJens Preben Morth 🇪🇺 🇩🇰 🐾 🌍@Jpmorth28 Jun 2022
Super excited to get started with this new project together with @daniel_otzen, @TeknologiskInst, @UPorto and my amazing colleagues Peter West and Uffe Hasbro @UHMortensenLab at @DTUbioengineer, @DTUtweet
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Our #CRISPR plasmid collection in @Addgene just got updated, see addgene.org/Uffe_Mortensen/ #cellfactories #yeast #Synbio
Tomas Strucko (@tomas_strucko) profile pictureTomas Strucko@tomas_strucko12 Mar 2022
Plasmids from our #CRISPR/Cas9 toolkit for CTG-clade yeasts (#Debaryomyces #hansenii) published in @OUPSynBio doi.org/10.1093/synbio/ysab0… is now available in @Addgene! 👇addgene.org/browse/article/2… @UHMortensenLab @JLMart81
A CRISPR/Cas9 method facilitates efficient oligo-mediated gene editing in Debaryomyces hansenii

A CRISPR/Cas9 method facilitates efficient oligo-mediated gene editing in Debaryomyces hansenii

Abstract. Halophilic and osmotolerant yeast Debaryomyces hansenii has a high potential for cell factory applications due to its resistance to harsh environ

academic.oup.com
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Uffe H. Mortensen's Lab retweeted
Ostenfeld Larsen Lab (@LarsenOstenfeld) profile picture
Ostenfeld Larsen Lab@LarsenOstenfeld20 Jan 2022
A great day in the lab with two papers driven by former PhD student Yaojie Gou out in ACS Journals :-) doi.org/10.1021/acs.jnatprod…, doi.org/10.1021/acs.orglett.…
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Check out an addition to our #CRISPR toolset doi.org/10.1093/synbio/ysab0… An interesting non-conventional yeast from CTG-clade Debaryomyces hansenii can now be efficiently engineered. Published in @OUPSynBio #Synbio #OA #Biotechnology.
A CRISPR/Cas9 method facilitates efficient oligo-mediated gene editing in Debaryomyces hansenii

A CRISPR/Cas9 method facilitates efficient oligo-mediated gene editing in Debaryomyces hansenii

Abstract. Halophilic and osmotolerant yeast Debaryomyces hansenii has a high potential for cell factory applications due to its resistance to harsh environ

academic.oup.com
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Uffe H. Mortensen's Lab retweeted
Tomas Strucko (@tomas_strucko) profile picture
Tomas Strucko@tomas_strucko13 Oct 2021
and the link: doi.org/10.1093/synbio/ysab0…
A CRISPR/Cas9 method facilitates efficient oligo-mediated gene editing in Debaryomyces hansenii

A CRISPR/Cas9 method facilitates efficient oligo-mediated gene editing in Debaryomyces hansenii

Abstract. Halophilic and osmotolerant yeast Debaryomyces hansenii has a high potential for cell factory applications due to its resistance to harsh environ

academic.oup.com
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Today I am presenting the latest developments from our lab @ICY15_Vienna. Tune in!
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