Biomedical engineering is the application of engineering principles to the understanding and solving of medical problems.

Joined June 2021
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A pioneering neurotherapeutic methodology developed by researchers at the Massachusetts Institute of Technology (MIT) leverages synchronized sensory entrainment to target the structural and cellular pathologies of Alzheimer's disease. The non-invasive protocol exposes subjects to coordinated visual and auditory stimuli engineered to cycle exactly 40 times per second, an acoustic and optical frequency that corresponds directly with naturally occurring gamma brainwaves. This specific multi-sensory stimulation drives local neural networks into alignment, artificially reinforcing the high-frequency oscillatory patterns that are frequently compromised during the early, progressive stages of neurodegenerative decline. By stabilizing these fundamental electrical rhythms across high-order cortical structures, the treatment initiates a systemic cascade of neuroprotective physiological changes throughout the central nervous system. The primary cellular mechanism driving this therapeutic response centers on the physical transformation of microglia, the resident innate immune cells of the human brain. Under normal physiological conditions, microglia remain in a resting state, but the continuous exposure to 40 Hz gamma entrainment prompts these cells to shift rapidly into an active, phagocytic morphology. Once activated, these specialized immune units systematically target and engulf the neurotoxic accumulations of amyloid-beta plaques and hyperphosphorylated tau tangles that disrupt intercellular communication and precipitate neuronal cell death. Beyond facilitating the clearance of these toxic protein aggregates, longitudinal clinical monitoring demonstrates that regular multi-sensory entrainment sessions meaningfully decelerate progressive brain atrophy, protect vulnerable synaptic connections from premature degradation, and preserve essential memory and executive functions in patients diagnosed with mild-to-moderate Alzheimer's disease. Because the entire treatment platform relies exclusively on external, specialized light-emitting diodes and calibrated acoustic hardware, the therapy bypasses the traditional systemic toxicities and complex metabolic side effects associated with conventional biochemical pharmaceuticals. This favorable safety profile enables patients to receive consistent, long-term therapeutic dosing directly in a home setting under minimal clinical supervision. As multi-center clinical trials advance to confirm long-term behavioral efficacy and evaluate standardized treatment intervals, this accessible, non-pharmacological strategy stands to radically reshape contemporary neurodegenerative care paradigms, providing a low-risk, scalable therapeutic intervention for millions of families globally. [Chan, D., Suk, H. J., Jackson, B. L., Milman, N. P., Stark, D., Klerman, E. B., & Tsai, L. H. Gamma frequency sensory stimulation in mild probable Alzheimer's disease patients. PLOS ONE]
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🤩 #BMES2026 here we come! 🛬🌴🏖️ We are excited to represent @UTEPBME with 3 podium presentations on #nanomedicine! @wilsonpoon is also chairing a session on Molecular Sensors & Nanodevices! Come find us, we look forward to catching up and chatting science! 🔬🧬🔎 – at El Paso, TX
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🧬 Scientists Are Finding New Ways to Bring Sight Back to the Blind What if some forms of blindness could one day become treatable? Scientists are exploring gene therapy, stem cells, and tiny visual implants that could help some people regain part of their sight. But the real breakthrough may depend on something hidden inside the eye. One treatment, called Luxturna, is already approved for certain patients with an inherited retinal disease caused by mutations in both copies of the RPE65 gene. However, it only works when enough retinal cells remain to respond to treatment. Researchers are also testing ways to repair damaged retinal tissue and send visual signals to the brain using special devices. Some approaches show promise, but many are still experimental. The biggest mystery is how much sight can be restored—and who can benefit. Blindness has many different causes, and damage to the optic nerve can present challenges that retinal treatments cannot solve. The future of vision restoration is advancing, but restoring normal eyesight remains a major scientific challenge. Source: U.S. Food and Drug Administration. . FDA approves novel gene therapy to treat patients with a rare form of inherited vision loss.
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🧠 Scientists Replaced More Than 85% of Brain Immune Cells in Mice, Offering New Hope for Brain Diseases. What if damaged brain cells could be replaced by healthy ones? Scientists at Stanford Medicine are exploring a remarkable approach involving microglia, the brain’s immune cells that help clear waste and protect nerve cells. In experiments involving mice with a fatal genetic brain disease, researchers introduced healthy precursor cells that developed into microglia. These cells helped deliver missing enzymes to neighboring brain cells, reduced brain damage, and improved movement and survival. The results are promising, but there is an important catch: this treatment remains experimental. It has not been proven to cure these diseases in humans. Could replacing the brain’s own immune cells become a future treatment for devastating neurological disorders? Scientists are working to find out. Source: Shibuya, Y., et al. Treatment of a genetic brain disease by CNS-wide microglia replacement. Science Translational Medicine, 14(636), eabl9945.
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🚨: MIT scientists create injectable gel that regrows damaged nerves, restores sensation completely.
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A daily dose of dark chocolate lowers blood pressure and protects arteries. A large review led by researchers at the University of Surrey suggests that flavan-3-ols—natural compounds found in tea, cocoa, dark chocolate, apples, and grapes—can modestly lower blood pressure and support vascular health. Analyzing data from 145 randomized controlled trials, the team found that regular intake of flavan-3-ol–rich foods led to meaningful reductions in blood pressure, particularly among people with elevated or high readings. In some participants, the magnitude of blood pressure reduction was comparable to that achieved with certain blood pressure medications, underscoring the potential of diet as an adjunct tool in cardiovascular prevention and management. Beyond blood pressure, flavan-3-ols were shown to improve endothelial function, enhancing the performance of the inner lining of blood vessels independently of any change in blood pressure. This suggests broader cardiovascular benefits, such as better regulation of blood flow and reduced vascular strain. Lead author Professor Christian Heiss emphasized that while these findings are promising, flavan-3-ol–rich foods should not replace prescribed treatments or professional medical advice. Instead, modest daily amounts of tea, dark chocolate, apples, or cocoa powder may be a practical and enjoyable addition to a balanced diet, supporting heart health as part of an overall healthy lifestyle, especially in individuals at higher cardiovascular risk. Reference University of Surrey. (2025). Flavan-3-ols and blood pressure: Findings from randomized controlled trials. University of Surrey.
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🧠 This Mushroom May Hold Surprising Clues to Brain Health. Scientists are investigating lion’s mane (Hericium erinaceus), an edible mushroom containing compounds that may influence nerve growth and brain function. Animal studies suggest these compounds could support certain aspects of memory and mood. A small 2010 human study involving 30 women also reported improvements in self-reported anxiety and depression symptoms after four weeks of consuming lion’s mane cookies. But here’s the mystery: Can this mushroom actually protect the human brain? Researchers have not yet confirmed its effectiveness as a treatment for depression or nerve damage. More human studies are needed. Nature may hold promising clues, but scientists are still searching for answers Source: Nagano, M., et al. (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231–237.
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🚨: It's official — HIV is no longer a terminal disease! Modern Antiretroviral Therapy (ART) reduces HIV to undetectable levels, allowing patients to live normal lifespans.
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🧠 YOUR BRAIN MAY NEED A WALK MORE THAN ANOTHER CUP OF COFFEE! What if just 20 minutes of walking could help you think more clearly, feel better, and improve your focus? The secret may lie in what happens inside your brain when you move. Every step gets your body working. Walking increases your heart rate and helps deliver oxygen and nutrients to your brain. Research suggests that even a short bout of physical activity can improve attention and certain aspects of brain function. But there's more. Walking can also boost your mood and help you feel more alert, especially when you break up long periods of sitting. You don't need an expensive gym membership or an intense workout. A simple 20-minute walk may be a great place to start. Your next great idea might begin with your next step. Instead of sitting for another 20 minutes, why not give your brain a little movement? Source:
Chang, Y. K., Labban, J. D., Gapin, J. I., & Etnier, J. L. (2012). The effects of acute exercise on cognitive performance: A meta-analysis. Brain Research, 1453, 87–101.
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🚨 These Goggles Could Help Surgeons See Cancer Glow During Surgery What if cancer cells could light up like tiny warning signals inside the human body? 🔬 Nigerian-born scientist Dr. Samuel Achilefu and his research team developed special medical goggles designed to help surgeons see cancerous tissue that might otherwise be difficult to spot. Here’s the fascinating part. Before surgery, a fluorescent dye is introduced into the body. When exposed to specific light, the dye helps targeted tissue stand out. Special goggles detect this signal, allowing surgeons to see highlighted areas while operating. Why does this matter? One of the biggest challenges in cancer surgery is knowing whether all the tumor has been removed. These goggles could help surgeons identify suspicious tissue and examine tumor boundaries more clearly, potentially helping them make better decisions during an operation. The goal is simple but powerful: help surgeons spot cancer that might otherwise be missed and reduce the chance of needing another operation. The technology has been tested in research and clinical settings, and scientists are continuing to improve it. It is not a perfect cancer detector, but it offers a promising way to bring hidden details into view. Sometimes, a medical breakthrough begins with a remarkable idea: What if surgeons could see what the human eye cannot? Source:
Mondal, S. B., et al. Optical see-through cancer vision goggles enable direct patient visualization and real-time fluorescence-guided oncologic surgery. Journal of Biomedical Optics, 22(3), 036007.
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👁️ Scientists have unlocked the secret to natural eye repair by removing a single protein that blocks the retina from regenerating. For decades, medical science operated on the assumption that mammalian eyes could not repair themselves once vision loss occurred. Unlike zebrafish or amphibians, human retinas lack the innate ability to regrow damaged cells, rendering conditions like macular degeneration and glaucoma largely irreversible. However, researchers have identified a key biological obstacle preventing this natural repair process: a protein named PROX1 that acts as a strict molecular stop sign inside retinal support cells. By developing a targeted therapy to neutralize this protein, scientists successfully prompted mouse retinas to reprogram their own cells and naturally rebuild light-sensing tissue. The intervention led to long-term vision recovery, proving that the cellular machinery for eye regeneration was merely dormant rather than lost. This breakthrough marks a monumental shift in ophthalmology, offering real hope that future treatments could actively restore sight rather than simply slowing down its decay. source: Kim, M., Lee, E. J., & Kim, J. W. PROX1 inhibition restores vision through retinal neural regeneration. Nature Communications.
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A Vitamin K Precursor Shows Promise in the Fight Against Cancer Scientists are investigating a compound linked to vitamin K that may help destroy cancer cells, opening a new avenue for cancer research. Vitamin K is best known for its role in blood clotting, but researchers are exploring whether certain related compounds could also have effects on cancer cells. The big question is whether this discovery can lead to a safe and effective treatment for patients. A 2024 study published in Science found that a vitamin K precursor called menadione sodium bisulfite suppressed prostate cancer progression in mice by triggering oxidative cell death. This was animal research, not proof of an effective cancer treatment in humans. Source: Swamynathan, M. M., et al. (2024). Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function. Science
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The Animals That Can Regrow Limbs May Hold a Secret to Human Regeneration Imagine losing an arm and growing a new one. It sounds like science fiction, but some animals can already do something remarkably close to this. Salamanders, especially axolotls, can regenerate entire limbs, rebuilding bones, muscles, nerves, and blood vessels. Even more fascinating, their cells can coordinate the complex process of rebuilding damaged body parts. Scientists are investigating how they do it. By studying the genes and molecular signals behind regeneration, researchers hope to discover ways to help the human body repair severe injuries more effectively. But there is a huge challenge. Rebuilding a human limb would require the precise formation of bones, muscles, joints, nerves, and blood vessels—all working together perfectly. Humans cannot currently regrow an entire lost limb. However, regenerative medicine and stem-cell research are helping scientists understand how damaged tissues might one day be repaired more effectively. Nature has already mastered something medicine is still struggling to achieve. Could the secret to regrowing human body parts be hidden inside the cells of a tiny salamander? The answer may reshape the future of medicine. Source:
McCusker, C., & Gardiner, D. M. The axolotl model for regeneration and aging research: A mini-review. Gerontology, 57(6), 565–571.
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🧬 Scientists Develop an Injectable Gel That Could Help Repair Damaged Nerves What if damaged nerves could one day be repaired with an injection? Scientists are exploring a promising new approach to nerve repair using special hydrogels — soft, water-rich materials designed to support the body's healing process. The science behind the breakthrough Some researchers are developing conductive hydrogels that mimic aspects of natural tissue. These materials may provide a supportive environment for nerve fibers to grow and reconnect across damaged areas. The potential is enormous. Severe nerve injuries can cause lasting numbness, pain, and loss of movement. In the future, advanced materials could help damaged nerves recover and potentially reduce the need for certain complex surgical procedures. However, the results depend on the specific material and type of injury. An injectable gel that fully repairs severed nerves and restores normal sensation has not yet been established as a routine human treatment. The ultimate goal is to help the body rebuild its own connections, bringing new hope to people living with nerve damage. Sources:
MIT News. (n.d.). Research on nerve repair and biomaterials. Massachusetts Institute of Technology.
Nature Communications. (Research on conductive hydrogels and nerve regeneration)
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A new nasal spray reversed signs of brain aging and restored memory performance in preclinical trials, and it worked in just weeks. Scientists at Texas A&M University have unveiled an experimental nasal spray that appears to reverse key markers of brain aging. The therapy targets neuroinflammaging, the chronic, low-level inflammation deep in the brain’s memory center that slowly degrades cognitive function and increases the risk for conditions like Alzheimer’s disease. By delivering microscopic biological packages known as extracellular vesicles directly into the nasal passages, the treatment bypasses the blood-brain barrier without requiring surgical or invasive procedures . In preclinical trials, just two doses spaced two weeks apart produced results within weeks, calming hyperactive immune cells, restoring neuronal cellular energy, and boosting memory performance for several months. While human clinical trials are still needed to confirm these findings in patients, the observations indicate that age-related mental decline may not be an irreversible fate. Researchers hope this accessible approach could one day offer a simple, non-invasive alternative to complex neurological treatments and prolonged medications. [Madhu, L. N., Kodali, M., Rao, S., et al. (2026). Intranasal human NSC-derived EVs therapy can restrain inflammatory microglial transcriptome, and NLRP3 and cGAS-STING signalling, in aged hippocampus. Journal of Extracellular Vesicles, 15(2). DOI: 10.1002/jev2.70232]
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Scientists May Have Found a Way to Regrow Lost Knee Cartilage What if damaged knee cartilage could one day grow back instead of being replaced by surgery? Scientists at Stanford Medicine have discovered a promising approach that could change how we treat arthritis. In a study published in Science in June 2026, researchers found that blocking a protein linked to aging, called 15-PGDH, helped restore cartilage in older mice and protected against arthritis after knee injuries. The surprising part? The treatment also showed signs of cartilage regeneration in human cartilage samples taken during knee replacement surgery. Instead of adding stem cells, it appeared to encourage existing cartilage cells to behave in a younger, healthier way. Could this eventually reduce the need for knee replacement surgery? Scientists are hopeful, but human clinical trials are still needed to prove the treatment works safely in patients. For now, this is a promising discovery—not yet a cure for arthritis. Source:
Singla, M., et al. (2026). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science, 391(6789), 1053–1062.
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Three days without food, and your immune system rebuilds itself from scratch. That's what Dr. Valter Longo's team at USC's Leonard Davis School found when they put 72-hour fasting under the microscope. Here's how it plays out. Go long enough without eating and your body burns through its glucose and fat reserves, then starts throwing out old, damaged immune cells. Eat again and stem cells wake up, flooding you with brand new white blood cells. The switch behind it all is a gene called PKA. Turn it off and stem cells flip straight into regeneration mode. It worked in mice. It worked in chemotherapy patients too, people whose immune systems usually get wrecked by treatment. No drugs. No supplements. Just an empty plate. Source: Valter Longo, USC Leonard Davis School
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A wonderful full-circle moment this past Friday when we hosted Prof. Warren Chan (@TheChanLab) from @NTUsg as our @UTEPBME Seminar speaker 🎓✨ Having my former PhD mentor fly across the world to visit my lab, meet my students, & inspire the department meant the world to me💡🥹🙌🏻 – at El Paso, TX
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Japanese researchers have reported a remarkable development in regenerative medicine after a patient with a spinal cord injury regained the ability to stand independently following experimental stem cell treatment. The early results offer new hope for people living with paralysis, although scientists emphasize that the treatment remains experimental. ‌ Researchers at Keio University used induced pluripotent stem cells, or iPS cells, which can be transformed into specialized cells. They developed neural precursor cells and transplanted them into damaged spinal cord tissue, hoping to support nerve repair and restore communication between the brain and body. In the small early-stage trial involving 4 patients, one participant reportedly regained the ability to stand independently, while another showed improvements in movement. ‌ The findings are encouraging because severe spinal cord injuries often cause permanent loss of movement and sensation. However, the treatment has not been proven to reverse paralysis consistently, and the reported recovery does not establish that patients can walk unaided. Larger clinical trials are necessary to evaluate long-term safety, effectiveness, and which patients could benefit.
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🚨 A Wound That Heals in Just Hours? Scientists have created a skin-like hydrogel that could dramatically speed up wound healing. In testing, wounds closed by up to 90% within 4 hours and fully healed within 24 hours. The material keeps wounds moist, protects damaged tissue, and helps the body repair itself more efficiently. If future studies confirm these results in humans, it could transform treatment for cuts, burns, and chronic wounds. Source:
Nature. Skin-inspired hydrogel research on accelerated wound healing. Nature Publishing Group.
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