Synthesis, chemical glycobiology, MedChem, host-microbe interaction, germinal center, RNA, post-translational modification… https://teapaw.org/t.co/3rZU3TQP1K
Utrecht, The Netherlands
Joined June 2018
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CBDD (Chemical Biology & Drug Discovery) retweeted
We have a 3-year post-doc position open. Apply now and join BioBeyond_NL to power up mass spec studies with new chemical biology tools!
uu.nl/en/organisation/workin…
CBDD (Chemical Biology & Drug Discovery) retweeted
A molecular trio anchors RNAs on the cell surface dlvr.it/TPv814
CBDD (Chemical Biology & Drug Discovery) retweeted
Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors dlvr.it/TPxYy6
CBDD (Chemical Biology & Drug Discovery) retweeted
“I’m thrilled to receive an ERC-CoG 2025. This reflects the collective effort of many brilliant mentors, collaborators, students, and colleagues — thank you for shaping this journey. Douze points from Brussels!” #glycotime @UU_Glycoscience erc.europa.eu/news-events/ne…
New @angew_chem paper jointly supervised by @zeshi_li and @TheBoonsGroup describes the chemoenzymatic synthesis of all O-acetylated forms of GD3 as intact glycolipids, and the use thereof to study virus binding in cellular context.
onlinelibrary.wiley.com/doi/…
Tremendous help from @RobertPdeVries1 lab and @LiangRuonan with the red blood cell related work.
CBDD (Chemical Biology & Drug Discovery) retweeted
Super excited that our division is part of this great scheme! #glycotime @UU_Glycoscience @TheBoonsGroup @zeshi_li uu.nl/en/news/beyond-dna-nwo…
Congratulations to CBDD researchers, Geert-Jan Boons and @zeshi_li and members of #BioBeyond_NL, a consortium co-led by Maastricht, Utrecht, Radboud University and LUMC researchers to advance (glyco)proteomics, glycomics and spatial omics. Read more👇
uu.nl/en/news/beyond-dna-nwo…
New @J_A_C_S paper from @TheBoonsGroup, spearheaded by Mehman @mehmanbunyadov describes the chemoenzymatic synthesis of intact HNK-1 glycolipids, which were used to glycoengineer erythrocyte surface for binding and lysis assays.
pubs.acs.org/doi/10.1021/jac…
CBDD (Chemical Biology & Drug Discovery) retweeted
Excited to have this story out on bioRxv! #glycotime #lovevirology #H5N1 The receptor binding properties of H5Nx influenza A viruses have evolved to promiscuously bind to avian-type mucin-like O-glycans. biorxiv.org/content/10.1101/…
CBDD (Chemical Biology & Drug Discovery) retweeted
Congratulations to the research team on their recent publication in Nature, titled "Receptor-binding specificity of a bovine influenza A virus" 💯🦠🐮
#InfluenzaResearch #CollaborativeScience @tompkins_lab @ugavetmed @UGAResearch
nature.com/articles/s41586-0…
CBDD (Chemical Biology & Drug Discovery) retweeted
Excited to share an update on heparan sulfate (HS)-associated cell-surface RNA (hepRNA):
biorxiv.org/content/10.1101/…
Another heads-up for the #glycoRNA community from Uni Marburg👇There are many glycoproteins co-isolated with RNA by TRIzol method. They persist throughout RNA sample processing and are not easily degraded by proteinase K. Careful what you are looking at in an RNA blot!
Proteins are a source of glycans found in preparations of glycoRNA biorxiv.org/content/10.1101/… #biorxiv_molbio
Yes, viruses like it sweet! @UUUIPS CBDD researchers @TheBoonsGroup and @RobertPdeVries1, together with researchers in Erasmus Rotterdam, were awarded an #ENW-XL from the Dutch Research Council (NWO). It’s #glycotime for virology! #glycovirology
CBDD (Chemical Biology & Drug Discovery) retweeted
I'm super excited that our consortium has been funded by the NWO! Can't wait to get started! @DebbyvanRiel @miranda_graaf @bart_haagmans @LisaBauerVirus @TheBoonsGroup @UU_Glycoscience @UUUIPS #glycotime
nwo.nl/en/news/64-million-eu…
New @J_A_C_S paper from @TheBoonsGroup demonstrating peptidoligase-mediated, site-specific introduction of N-glycans into native proteins such as insulin, IL18 and IFNalpha-2a. This project was led by former post-doc Ana Gimeno. pubs.acs.org/doi/10.1021/jac…
CBDD (Chemical Biology & Drug Discovery) retweeted
We got an opinion: sciencedirect.com/science/ar…
CBDD (Chemical Biology & Drug Discovery) retweeted
Another week another editors’ pick, now out in ACS Infectious Diseases. HKU is quite promiscuous for glycan cores snd only really cares for 9-0-acetylated sialic acids pubs.acs.org/doi/10.1021/acs…
HKU1 - TMPRSS2 done ☑️! Now time for OC43!
The new issue is out! 👉 lnkd.in/ectCFkH
This issue features a high resolution structural analysis of the Prototype Foamy Virus, a pan-cancer proteogenomics study that expands the landscape of therapeutic targets and the recognition of the TMPRSS2 host receptor by human coronavirus HKU1!
On the cover: The cover image represents human coronavirus HKU1 in complex with its receptor TMPRSS2 present on a target cell membrane, as elucidated by Fernández et al. The crystal structure of the HKU1-CoV spike in complex with TMPRSS2 provides insights on coronavirus receptor usage, host specificity, and pathogenicity.
Cover Image: Nell Saunders
