PostDoc at Scripps Research in @HuangMia @_chrisgparker_ lab. Chemical Biology. Focus on chemical proteomics.
Joined July 2018
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Weichao Li retweeted
Check out our recent collaboration with @abbvie in @CellChemBiol. We identifed compounds that potently clear tau aggregates. After chemoproteomics and functional studies, we found it covalently targets ER protein P4HB (after metabolic activation). sciencedirect.com/science/ar…
Weichao Li retweeted
Thrilled to collaborate with these groups and show how N-linked glycosylation influences the binding of small molecules to the proteome! #glycotime
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with @ForliLab, @HuangMia & @bmsnews. biorxiv.org/content/10.1101/…
Weichao Li retweeted
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with @ForliLab, @HuangMia & @bmsnews. biorxiv.org/content/10.1101/…
Weichao Li retweeted
Excited to share the final version in
@nchembio. Lots more mechanistic insights & characterization, including our inhibitors disrupt PPIs with mTOR components & induce lysosomal degradation of SLC15A4, & more. A promising target for autoimmune conditions. nature.com/articles/s41589-0…
Weichao Li retweeted
A new @nchembio study, led by @_chrisgparker_ alongside Jacob M. Wozniak and Weichao Li, created a high-resolution technique for finding new druggable sites for any human disease, from cancer to Alzheimer’s disease.
More at: ow.ly/9NLN50Qnb7x
ALT A protein with unknown binding sites (left), versus a protein showing high-resolution binding site mapping (right). Credit: Scripps Research
Weichao Li retweeted
nature.com/articles/s41589-0… Delighted to share our recent work. We developed an enhanced chemoproteomic workflow to determine PAL probe interaction sites in cells, enabling ID of diverse binding pockets, providing evidence of their chemical tractability & more w/@ForliLab & @bmsnews
Weichao Li retweeted
Excited for this @scripps Chem collaborative work out in @Nature w/@BaranLabReads & Lairson Lab. Has a bit of something for everyone…herculean total synthesis, structural reassignment, chemoproteomics, new druggable target, in-depth functional characterization & more
The final version of this study was published today in @Nature : nature.com/articles/s41586-0…
Weichao Li retweeted
The final version of this study was published today in @Nature : nature.com/articles/s41586-0…
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
Weichao Li retweeted
Humbled to be among this amazing cadre of scientists! Grateful for awesome team members @scrippsresearch that are eager to make an impact on #glycotime! Thank you also to a village of mentors and letter writers. #SloanFellow
We are delighted to announce the winners of this year’s Sloan Research Fellowship! These outstanding researchers are shining examples of innovation and impact—and we are thrilled to support them. Meet the winners here: sloan.org/fellowships/2023-F… 🎉 #SloanFellow #STEM #ScienceTwitter
Weichao Li retweeted
Big congrats to Junchen and @BaranLabReads on this feat! Excited to be able to contribute w/@WChembio to this story. A great example of how enabling total synthesis can be to reveal new and exciting biology.
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
Weichao Li retweeted
Happy to share our (w/ @Teijaro_Lab) integrated chemoprotoemic approach to develop functional inhibitors of SLC15A4 - a challenging target that controls some exciting biology
Chemoproteomics-guided Development of SLC15A4 Inhibitors with Anti-inflammatory Activity biorxiv.org/cgi/content/shor… #bioRxiv
Weichao Li retweeted
The final version of this work is now out in @J_A_C_S. A big congrats to Wesley, Anny and team!
pubs.acs.org/doi/10.1021/jac…
Check out our newest work on using chemoproteomic platform to exploring unexpected folate-interacting/binding proteins and reveals folate-modulated growth and development in Arabidopsis. Collaborate with fantastic people from CAAS and UGhent @ResearchUGent. @ThePlantCell
The 5-formyl-tetrahydrofolate proteome links folates with C/N metabolism and reveals feedback regulation of folate biosynthesis #PlantSci doi.org/10.1093/plcell/koab1…
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Weichao Li retweeted
Online @ACSCatalysis Reports first #ascorbylatedalkaloids #enzyme in #securinegaalkaloids biosynthesis. We reveal the key intermediate in the biosynthesis of C-2 and C-3 functionalized derivatives of #Securinega alkaloids
#firstcorrespondingauthorpaper pubs.acs.org/doi/10.1021/acs…
Weichao Li retweeted
Thrilled to share my first publication as a first author! It's out! It's exciting! Glycans! 🔺🟦🟢🟡
@ScrippsGradPrgm @scrippsresearch #glycotime
pubs.acs.org/doi/10.1021/acs…
Weichao Li retweeted
Woohoo! We are ecstatic to share our latest work "Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling." Grateful to reviewers who provided feedback, even in a pandemic. #glycotime @geno_joeh @WChembio @_chrisgparker_ pnas.org/content/early/2020/…