@WRnai

A nerdy worm

staff.ustc.edu.cn/~sguang/
Joined December 2016
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  • Following221
  • Followers63
1Media
Today marks the 15th anniversary of our lab. Over sixty people joined the celebration, including former undergraduates, master's students, and PhD students who have been part of the lab, as well as current lab members and even their students. Among the attendees were
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three professors recognized as Overseas Excellent Young Scholars (two from the University of Science and Technology of China and one from the Shanghai Institute of Biochemistry and Cell Biology, CAS), two professors from Anhui Medical University, and two associate professors
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(from USTC and Soochow University). May the lab continue to thrive and flourish in the next 15 years.
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rRNA intermediates associate with nucleolar reshaping in C. elegans academic.oup.com/nar/article…

rRNA intermediates associate with nucleolar reshaping in C. elegans

Abstract. The nucleolus is a multilayered organelle essential for ribosome biogenesis, yet how ribosomal RNA (rRNA) events coordinate its organization rema

academic.oup.com
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A conserved antioxidant defense at the endoplasmic reticulum membrane: Cell Reports cell.com/cell-reports/fullte…

A conserved antioxidant defense at the endoplasmic reticulum membrane

Ji et al. identify ERGU-1/TMEM161B as an evolutionarily conserved ER-transmembrane protein that modulates oxidative stress generated during oxidative protein folding. This critical guardian maintains...

cell.com
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In @elife: Identification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans doi.org/10.7554/eLife.111326…
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Shouhong Guang retweeted
Qin Yan, PhD@QinYan1Mar 28
I am really honored for this. This would not be possible without the hard work of my trainees, guidance by mentors including Joan and Ron Conaway @UTSWMedCenter , @kaelin_lab, David Stern, and Jeff Sklar, and support of my colleagues @yalepathology @YaleMed @Yale, and my family.
YSM Pathology
@yalepathologyMar 26
Congratulations to @QinYan1, Professor of #Pathology @YaleMed, on being named a Fellow of the @aaas. This prestigious honor recognizes his extraordinary achievements as a research scientist. @YaleCancer
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Identification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans biorxiv.org/content/10.64898…
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Heat stress-induced condensation of G3BP1 in perinuclear P-bodies in C. elegans' germline biorxiv.org/content/10.64898…
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rdcu.be/eRT2i The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription machinery to initiate piRNA expression within heterochromatic clusters
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NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors: Cell Genomics cell.com/cell-genomics/fullt…

NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to...

Wang et al. performed a rare-variant-based association study and identified novel genes associated with hepatocellular carcinoma risk. The authors further revealed that NRDE2 promotes homologous...

cell.com
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TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in C. elegans sciengine.com/SCLS/doi/10.10… via @https://www.sciengine.com
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rRNA intermediates dictate nucleolar architecture in C. elegans biorxiv.org/content/10.1101/…

rRNA intermediates dictate nucleolar architecture in C. elegans

The nucleolus is a multilayered, membraneless organelle essential for rRNA transcription, processing and ribosome assembly; however, it remains largely unclear whether and how these molecular events...

biorxiv.org
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piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation nature.com/articles/s41594-0…

piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation

Nature Structural & Molecular Biology - Piwi-interacting RNAs (piRNAs) are vital for genome integrity and fertility. Here the authors reveal that spatial clustering of piRNA genes in...

nature.com
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rdcu.be/ey2RV Comprehensive profiling of the catalytic conformations of human Guanylate kinase
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pmc.ncbi.nlm.nih.gov/article… Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation

Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation

In response to nutrient scarcity, cells must reallocate their limited energy for cellular maintenance at the expense of certain processes. How such a tradeoff is achieved remains largely unknown. RNA...

pmc.ncbi.nlm.nih.gov
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Nucleolar proteomics revealed the regulation of RNA exosome localization by MTR4 - Molecular & Cellular Proteomics mcponline.org/article/S1535-…

Nucleolar Proteomics Revealed the Regulation of RNA Exosome Localization by MTR4

In BriefBiochemical fractionation followed by proteomics and fluorescent imaging approaches revealed the RNA helicase MTR4-modulated nucleolar proteome. The depletion of MTR4 or inhibiting transcri...

mcponline.org
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Nuage in color: Systematic protein tagging shows the compositional complexity of germ granules: Developmental Cell cell.com/developmental-cell/…
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The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA expression within heterochromatic clusters biorxiv.org/content/10.1101/…

The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA...

Metazoans utilize the small RNA pathway to regulate gene expression and maintain genome integrity. This pathway directs histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-met...

biorxiv.org
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The transcription machinery of piRNAs in worms and flies are quite similar. Both of them need an epigenetic reader and somehow recruits special transcription factor. worms: USTC -> UAD-2 -> TAF-12 flies: (kipferl)-> Rhino ->RDC -> moonshiner
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