Iñigo

Cuando votas a la izquierda y te das cuenta de que tu idea de la multiculturalidad conduce a una uniculturalidad en la que el que sobras eres tú.

I must admit, it was an fugly little thing at this point bobbling around lol. But fugly in a cute way? weird. Popped like a balloon. You've done amazing with it! well done! 💜 I wish someone could do this to me when I get bloated

Voilà la bête. Google vient de dévoiler son projet de datacenter géant à Châteauroux. 200 ha, 10 Md$ d'investissement et jusqu'à 1200 MW de puissance. Développement par étape sur 20 ans. Retour en force des Américains dans la ville 60 ans après le départ de l'US Air Force 🙂

Cyberattack on France’s national blood service (EFS) via its refrigeration contractor Coolworld. Hackers reset freezers keeping blood donor samples at -30°C to a target of 110°C. The thing that stopped it from destructive impact was an on-call technician who noticed the temperatures going up. Frozen plasma intended for transfusion was stored there too. Fortunately nothing was destroyed. This was a cyberattack on a sensitive layer of healthcare. From frozen peas to boiling plasma in three weeks...?

Los postes repetidores y el ejército de juglares intentarán revestir de épica un gesto que era obligado y disfrazar de estadista al tipo que se pasó las jornadas laborales insultando contribuyentes desde el móvil. Pero no hay "compol" que borre toda esta indignidad.

>be cell biology postdoc at UCLA, 1986 >job: purify vesicles from rat liver >ez >purify the vesicles >something else in the tube >weird little barrels, way bigger than a ribosome >fkisdis >purify the barrels instead >mostly protein, tiny bit of RNA >not related to vesicles at all >new organelle just dropped? >lab holds a naming contest >"vaults" "sure, "great name" " >write it up, publish >conclusion section: "function: unknown" >surely we'll figure it out in a couple years >reviewers: "are you sure this isn't just a virus" >prove it isn't a virus >apply for grants to study it >first question on every call: "what does it do" >"we're working on it" >be early 90s >vaults hang around the nucleus >"they must plug the nuclear pores" >they do not >be different scientist, Netherlands, 1995 >chasing LRP, mystery protein that shows up in chemo-resistant tumors >clone it >~88% identical to rat vault protein >it was vaults the whole time >whole cancer field piles on >a decade of papers on vaults and drug resistance >nobody ever proves vaults cause it >back at UCLA >one of the vault proteins binds telomerase >"guys what if this is the fountain of youth" >knock it out in mice >telomeres fine, aging fine, mice fine >2002 >knock out the main vault protein >mice: perfectly healthy >knock out all three vault proteins >completely vaultless mice >mice: basically fine, some subtle immune stuff >mfw something in every cell since the dawn of eukaryotes does nothing obvious >"just test it in yeast" >yeast don't have vaults >"worms then" >no vaults >"fruit flies" >no vaults >mfw every easy model organism dropped them >try making recombinant vaults in insect cells >expecting to get some loose protein at best >get fully assembled vaults >can't find a single free copy of the protein anywhere >turns out ribosomes 3D-print the barrel straight off the mRNA >lolwut >still no function >be structural biologists >spend years modeling it as 96 proteins with 8-fold symmetry >2009 X-ray structure >it's 78 proteins, 39-fold >caps still blurry >2025: caps are closed, 13-fold, tiny hole in the middle >still no function >NIH funds vault research for 15 years >NIH: "so what does it do" >"...we're working on it" >NIH stops returning calls >if we can't figure out what it does, we'll make it do something >stuff a cancer-fighting chemokine inside the barrel >inject into mouse lung tumors >immune cells swarm in, tumors shrink >2011: "human trials within three years" >2024: "human trials next year" >2025 database: preclinical >start a YouTube channel explaining vaults to anyone who'll listen >be different scientist, Broad Institute >want to record what genes a cell turned on over time >try tethering mRNA to a bacterial protein >doesn't work >stumble onto a YouTube channel about some obscure barrel organelle >engineer vaults to grab mRNA >RNA half-life goes from ~17 hours to ~132 hours >publish in Science, 2026 >use it to catch drug-resistance genes in lung cancer cells before the drug even hits >the vault guy is thrilled >still nobody knows what vaults are for >be epigeneticists >screen the whole genome for methylation set at random in the early embryo >separately study kids conceived in different seasons in rural Gambia >both screens independently point at the same gene >it's the goddam vault RNA gene >its methylation depends on conditions around conception, locked in for life >linked to cancer outcomes, blood sugar, cleft palate >mfw the mystery barrel has a mystery RNA that remembers when you were conceived >40 years later >one of the most abundant structures in your cells >still not in a single textbook cell diagram >we use it anyway because yolo >function: unknown

“Water, soil, and oxygen should not be infinitely accessible. They are assets that should be included in global economic balance sheets.” This is not satire. The World Economic Forum wants to monetise breathing.