André Dias (@_andre_Dias_) header
André Dias (@_andre_Dias_) profile picture

André Dias

@_andre_Dias_

Developmental Biologist @ NIMSB - NOVA Institute for Medical Systems Biology

 Lisbon, Portugal
Joined May 2017
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Photo by André Dias (@_andre_Dias_)Photo by André Dias (@_andre_Dias_)Photo by André Dias (@_andre_Dias_)Photo by André Dias (@_andre_Dias_)Photo by André Dias (@_andre_Dias_)Photo by André Dias (@_andre_Dias_)Photo by André Dias (@_andre_Dias_)Photo by André Dias (@_andre_Dias_)Photo by André Dias (@_andre_Dias_)Photo by André Dias (@_andre_Dias_)
Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan. biorxiv.org/content/10.1101/…
A temporal coordination between Nodal and Wnt signalling governs the emergence of the mammalian...

A temporal coordination between Nodal and Wnt signalling governs the emergence of the mammalian...

Nodal and Wnt signalling play an important role in the emergence of the mammalian body plan, primarily by orchestrating gastrulation and primitive streak formation. While the literature suggests that...

biorxiv.org
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Embryo, is the story of how one cell becomes millions that build a body within which a #HumanBeing emerges gradually—one cell at a time. It explores the origin of human nature and what #IVF, #EmbryoModels & artificial wombs mean for our future. amazon.com/Embryo-Becoming-A…
Image from Alfonso Martinez Arias (@AMartinezArias)
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André Dias retweeted
Development (@Dev_journal) profile picture
Development@Dev_journalJun 17
In this Obituary, Francesca Mariani & Mark Lewandoski write about Gail Martin, one of developmental biology's most influential conceptual architects, a scientist who reshaped how we think about signalling, pattern formation & genetic analysis in the mouse. doi.org/10.1242/dev.205795
Image from Development (@Dev_journal)
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We're thrilled to announce that the next Gastruloids Workshop will take place in Cambridge on 21–22 September! 🎉 Places are limited to the first 100 participants, register now: ad2267-qpebh.wordpress.com #gastruloids
Image from Apolline DELAHAYE (@Apolline_dlh)
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The next Gastruloid Meeting is in Cambridge!! 👇 See you there!
Apolline DELAHAYE (@Apolline_dlh) profile pictureApolline DELAHAYE@Apolline_dlhJun 8
We're thrilled to announce that the next Gastruloids Workshop will take place in Cambridge on 21–22 September! 🎉 Places are limited to the first 100 participants, register now: ad2267-qpebh.wordpress.com #gastruloids
Image from Apolline DELAHAYE (@Apolline_dlh)
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On the importance of basic research in Reproductive Biology #ReproBio and the need to fund their interface. With @_andre_Dias_and @InamdarManeesha #SCBEM #StemCells #IVF #ART academic.oup.com/molehr/arti…
Image from Alfonso Martinez Arias (@AMartinezArias)
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🔬 We’re hiring 3 Group Leaders in Paediatric Haematologic Malignancies 🤝 @CarrerasIJC & @IRSJD_info are joining forces to launch a new translational research hub focused on paediatric blood cancers. 📝 Apply now to drive real change for young patients: careers.carrerasresearch.org… @SJDbarcelona_es @fcarreras
Image from Josep Carreras Leukaemia Research Institute (IJC) (@CarrerasIJC)
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The Frenster Lab is here! 🍾 I am so excited to start my #EmmyNoether funded group at @UniFreiburg this summer. Our group studies #CellCompetition dynamics during embryonic development using #gastruloids from multiple species. FrensterLab.com
Frenster Lab | Cell Competition Dynamics

Frenster Lab | Cell Competition Dynamics

We study Cell Competition during Embryonic Development using 3D Gastruloids at the University of Freiburg. We view cells as interactive societies in development and cancer. Research, stem cells,...

frensterlab.com
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🥳I am happy to share our latest manuscript published in @NatureCellBio We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that it's highly pronounced in our system but also tightly restricted in time (1/12) nature.com/articles/s41556-0…
Mosaic gastruloids reveal a temporal restriction for developmental cell competition

Mosaic gastruloids reveal a temporal restriction for developmental cell competition

Nature Cell Biology - Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation...

nature.com
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A white paper on Stem Cell Based Embryo Models #SCBEM #Innovation #Ethics #Policy, from the community to highlight the potential of this new area of research and its impact in #ReproBiology shorturl.at/dAWL2
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1/2 Using #gastruloids @AnitaBanerjee19 Ram Sambasivan group find that Retinoic Acid gates the response of the epiblast to the Nodal:Eomes, Wnt:TbxT modules during mouse #gastrulation promoting the regionalization of the #PrimitiveStreak biorxiv.org/content/10.64898…
Image from Alfonso Martinez Arias (@AMartinezArias)
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Apply by Feb. 3 to become a Janelia Group Leader! Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader
Lead a lab at Janelia Pioneer next-generation tools for biological discovery Apply by Feb. 3, 2026 janelia.org/groupleader

ALT Lead a lab at Janelia Pioneer next-generation tools for biological discovery Apply by Feb. 3, 2026 janelia.org/groupleader

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To find out more about this work and the people behind it, we spoke to first author Tina Balayo, and to co-corresponding authors André Dias (@_andre_Dias_) and David Turner (@da40cambs). journals.biologists.com/dev/…
First author Tina Balayo (left) and corresponding authors André Dias (middle) and David Turner (right)

ALT First author Tina Balayo (left) and corresponding authors André Dias (middle) and David Turner (right)

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The power of the media: core culture conditions direct gastruloid development This Research Highlight showcases the work from Tina Balayo, André Dias (@_andre_Dias_ ), David Turner (@da40cambs) and colleagues: journals.biologists.com/dev/…
Figure 2 - NDiff227 gastruloids display a developmental delay in comparison to HM-N2B27 gastruloids. (A) Quantitative analysis of the roundness of gastruloids cultured in either HM-N2B27 or NDiff227 showed that HM-N2B27 gastruloids are significantly less ‘Round’ than their NDiff227 counterparts at 96 h (see also Fig. S4B). (B) Frequency of morphologies from panel A (top) with examples of gastruloids that would fall in each category (bottom; the left 'Protrusions' image is also shown in Fig. S4). (C) Light-sheet representative images (maximum projection) highlighting the expression patterns of Cdh1 (magenta) and Cdh2 (cyan) between HM-N2B27 gastruloids at 96 h and NDiff227 gastruloids at 90 h and 96 h. Scale bars: 100 μm. (Ci) Qualitative analysis of the average expression pattern of Cdh2 (N-cadherin), grouped into two categories (phenotypes I and II) and averaged across three independent replicates (top) and examples of the two categories (bottom; leftmost also in panel C).

ALT Figure 2 - NDiff227 gastruloids display a developmental delay in comparison to HM-N2B27 gastruloids. (A) Quantitative analysis of the roundness of gastruloids cultured in either HM-N2B27 or NDiff227 showed that HM-N2B27 gastruloids are significantly less ‘Round’ than their NDiff227 counterparts at 96 h (see also Fig. S4B). (B) Frequency of morphologies from panel A (top) with examples of gastruloids that would fall in each category (bottom; the left 'Protrusions' image is also shown in Fig. S4). (C) Light-sheet representative images (maximum projection) highlighting the expression patterns of Cdh1 (magenta) and Cdh2 (cyan) between HM-N2B27 gastruloids at 96 h and NDiff227 gastruloids at 90 h and 96 h. Scale bars: 100 μm. (Ci) Qualitative analysis of the average expression pattern of Cdh2 (N-cadherin), grouped into two categories (phenotypes I and II) and averaged across three independent replicates (top) and examples of the two categories (bottom; leftmost also in panel C).

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We would like to thank the reviewers for their inputs, the editor, and @Dev_journal for the interview journals.biologists.com/dev/… and the highlight journals.biologists.com/dev/…
The people behind the papers – Tina Balayo, André Dias and David Turner

The people behind the papers – Tina Balayo, André Dias and David Turner

Gastruloids are embryonic stem cell-derived in vitro models that mimic the axial patterning of the gastrulating embryo. The N2B27 basal medium in which mouse gastruloids are cultured can either be...

journals.biologists.com
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Out now in @Dev_journal! :) Lots of new things! Check it out!! journals.biologists.com/dev/…
N2B27 media formulations influence gastruloid development

N2B27 media formulations influence gastruloid development

Highlighted Article: This work explores the cellular and molecular sensitivity of the mouse gastruloid model system to variations in N2B27 media formulations, highlighting the need for careful media...

journals.biologists.com
André Dias (@_andre_Dias_) profile pictureAndré Dias@_andre_Dias_17 Mar 2025
Fun collaboration! All the nitty-gritty about N2B27 and gastruloids. Kudos to all the authors, particularly Tina Balayo (¡que va de primero!)
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#modularity elpais.com/ciencia/2025-11-1…
Muere Antonio García-Bellido, descubridor de las fronteras invisibles dentro de los seres vivos

Muere Antonio García-Bellido, descubridor de las fronteras invisibles dentro de los seres vivos

El biólogo, fallecido a los 89 años, deja un legado científico que roza las alturas de los nobeles Santiago Ramón y Cajal y Severo Ochoa

elpais.com
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1925: #OnThisDate 100 years ago, The Company of Biologists is founded by George Parker Bidder III. Throughout today, we will be posting some of our key milestones. Read more about the past 100 years at bit.ly/46RZxat
Poster of the 100-year history of The Company of Biologists

ALT Poster of the 100-year history of The Company of Biologists

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A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 October. Not only did he make a discovery that laid the foundations for the field of stem cell research, he also created one of the best environments for research at the Wellcome / CRUK Gurdon Institute. wellcome.org/news/sir-john-g…
Image from Gurdon Institute (@GurdonInstitute)
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John Gurdon en.wikipedia.org/wiki/John_G…, beacon of a generation that tackled head on the deepest question of biology: the development of an organism. The best tribute to him and his peers should be to remember and follow the path they forged for how to do Science in form and content.
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THANK YOU for many years of friendship, support and for sharing your great Science. La Pedrera #Barcelona #NotInTheGenes #CellsRUs #Cambridge
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