starting a cloud lab for assembling genes. first external contributor @pylabrobot, started team autom8 @retrobio_

Joined December 2020
ben ray retweeted
Google Research is also entering the wet lab biology space, using PyLabRobot! Check out the blog post: research.google/blog/groundi… Thanks for the shout out and contributions!
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ben ray retweeted
Exciting new project using PLR:
We are bringing agents to the wet-lab bench at Google Research to navigate complex biological landscapes. Learn how we are grounding agents in physical lab robotics to run fast closed-loop molecular design cycles, ultimately discovering single-digit nanomolar protein binders for cancer targets →goo.gle/4B5mMMB
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Replying to @exosome
If curious, this discovery is from Ann Zovein's work in 2008+. Was lots of hype about a new route to blood formation but not sure why it didn't go further than it did.
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you can just acquire hamilton STARs with a 10x markdown at bankruptcy auctions
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384x isopropanol precipitation plasmid minipreps in 5.5 fully automated hours. built with @pylabrobot
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ben ray retweeted
What humanity is able to observe is defined by the instruments available to make those observations. This robot is building "a telescope" that will help observe types of autoimmunity never-yet looked for and create a more complete synthetic human proteome.
96-plasmid yeast transformation and 384-spot plating across 4 SBS agar plates for clonal purification. solved by @pylabrobot in 3.25 hours rfc.geneticassemblies.com/rf…
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96-plasmid yeast transformation and 384-spot plating across 4 SBS agar plates for clonal purification. solved by @pylabrobot in 3.25 hours rfc.geneticassemblies.com/rf…
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ben ray retweeted
industrial automators: take note
i'm convinced that i can automate all of factorio using language models. so far, i created a mod within factorio that reads map and inventory data. right now, i'm training llama3 to make good early game decisions. i'll probably make this a series, wish me luck :)
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as I've been saying, generic models + PLR will be sufficient for very strong ai scientists
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Very excited to announce the PyLabRobot Cookbook from the Chory Lab! This cookbook showcases many usage examples and design patterns that should help you get started writing PyLabRobot code quickly. I strongly recommend this cookbook to anyone interested in lab automation!
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ben ray retweeted
Check out the PyLabRobot cookbook made by @wasserstein_rao and @chorye: chory-lab.github.io/plr-cook…
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3.5 hour miniprep solved by @pylabrobot
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list-price enjoyers pay $0.1 per pipette tip
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plate cameras are an underrated way to teach your robot what’s going on inside the well it’s pipetting
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SF Bankruptcy Auction: bid $10 on desks discover the lot is for 50 desks > nobody else bids now you have to move 50 desks.
posting our desk quotes because nobody does this SF: $8,000 desks $2,000 installation $2,000 after-hours installation $2,000 union labor $3,500 expedited delivery = $17,500, 1 month setup China: $8,000 desks $200 installation (Taskrabbit) $0 shipping = $8,200, 4 days setup
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ben ray retweeted
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(8/13) Serial transplantation asks whether stem cells can rebuild one blood system, make more stem cells (self-renew), and then rebuild another. A blood transfusion supplies mature cells for a limited time, but a true HSC graft establishes the source that continuously produces new blood and immune cells. Together, these grafts persisted through nearly 10 months of continuous blood production in vivo.
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I’m excited to share the first paper from my PhD research at @RetroBio_ (and my first paper as first author) - now on bioRxiv! Can we take adult human cells, turn them into blood-forming stem cells, and build a new blood system that is both functional and molecularly young? Our preprint: biorxiv.org/content/10.64898…
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Engrafted human iHSCs retain their youthful epigenetic age in vivo despite differentiation and prolonged transplantation.
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ben ray retweeted
I wrote about the call by frontier labs to start regulating DNA synthesis. I, and many lab biologists, think this would be damaging to American biotech. You can read my thoughts in core memory.
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