Dr Irwin Lim retweeted
If you’re just giving allopurinol at 300mg daily, you’re condemning up to 4/5 of patients to miss serum uric acid targets.
Allopurinol dosing is a massive cause of allopurinol failure.
Slow escalating to target is safe & effective, even in renal impairment
Lisa Stamp #ARANZRA24
Dr Irwin Lim retweeted
and clinical remission doesn’t mean imaging remission necessarily, and that might be a problem. A real need to ensure non-steroid therapies truly modify disease #ARANZRA24
Dr Irwin Lim retweeted
GUSTO trial (GCA treated with TCZ, and no steroids at all apart from an initial pulse):
1/18 had blindness
5/18 had aortic dilatation (update from Vasculitis 2024 Barcelona)
@MdWarrington asks: is TCZ really a disease modifying therapy in GCA?
#ARANZRA24
Dr Irwin Lim retweeted
Ken Warrington presents on GCA
⁃emerging treatments considering IL-6, IL-17, JAK-STAT targeted treatment
⁃Future treatment options…
#ARANZRA24 @MdWarrington @AusRheum
Dr Irwin Lim retweeted
Diagnosing acute gout is critical on the front line - Nicola Dalbeth highlights this validated tool designed for ED and primary care
mdcalc.com/calc/2175/acute-g…
#ARANZRA24
Dr Irwin Lim retweeted
TLL-018, the dual JAK1/Tyk2 inhibitor which caused all the chatter at #EULAR2023, now with more full data showing it absolutely smash tofacitinib in RA, with similar safety.
“This is a spectacular compound - unbelievably spectacular” - Roy Fleischmann
#ACR23 ABST0840 @RheumNow – at San Diego, CA
Dr Irwin Lim retweeted
That's a good pizza pie: rheuma.com.au/pizza-led-ra-t……
@RheumaRepublic
@KarinaBray7
#dontsubstituteyourRAmedsforpizza #needsvalidationanyvolunteers
Dr Irwin Lim retweeted
It was so nice to catch up with old friend @_connectedcare @RonantKavanagh and @drdavidliew at #EULAR2023 in Milan. Missing you @philipcrobinson. Despite what twitter has become today I met these fine folks all on social media over a decade ago!
Dr Irwin Lim retweeted
"Treatment with MTX is not associated with testicular toxicity, consistent with the very low concentration of intracellular MTX-PG. Therefore, therapy with MTX can be safely started or continued in men and with a wish to become a father."
ard.bmj.com/content/early/20…
In my clinic, we reassure males on MTX that it’s safe for them to try for a baby.
Gr8 to see clear reasons why this is true #eular2023
We really need to change the PIs to reduce patient worry!
Dr Irwin Lim retweeted
#Romosozumab superior to #denosumab in raising #spine BMD in glucocorticoid users with high #fracture risk
➡️Romosozumab may offer new treatment option in #glucocorticoid induced #osteoporosis
By Chi Chiu Mok #EULAR2023 OP0246
👉🏼ard.bmj.com/content/82/Suppl…
Via @ARD_BMJ
Dr Irwin Lim retweeted
Can’t escape ORAL Surveillance RCT talk
Lots of real world data on CV risk & JAKi here
(with all the selection, measurement bias)
First up: multinational JAK-pot study (n=>50k)
Even if you mirror the high-risk RCT cohort - not much there for MACE
OP0219 #EULAR2023 @RheumNow – at Milan, Lombardy
Dr Irwin Lim retweeted
Abatacept for 12m in ACPA pos arthralgias probably doesn’t impact RA progression that much once the abatacept stops…
but are there other reasons you might want to give it? Read on in the next tweet⬇️
APIPPRA study #EULAR2023 OP0130 @RheumNow
Dr Irwin Lim retweeted
Australian quality standard for RA is on its way rheuma.com.au/australian-qua… @AusRheum @drdavidliew @lynmarch1 @RachelleBuchbin @SusannaProudman
Dr Irwin Lim retweeted
Difficult to treat #rheumatoid #arthritis is a grab bag of multi drug failures or intolerant with high or LOW disease activity 3 groups and diff reasons for failure and diff risk factors. ? Sunset the D2T Pts? OP0117 #EULAR2023 @RheumNow @eular_org
Dr Irwin Lim retweeted
Replying to @_connectedcare
This is really important. Given the epidemiology of weight related conditions, & epi of autoimmune disorders - that’s a lot of potential medical misogyny we’re directing at our female patients! And given the slide before re set point & very low long term weight loss success.
Dr Irwin Lim retweeted
More great sharing practice & rehab strategies support -'Strong, Straight,Steady ' -great guidance for supporting Osteoporosis rehab -thx @PhysioWillGreg at #ARA23 @AusRheum
bgs.org.uk/sites/default/fil…
Dr Irwin Lim retweeted
Great to see the conference dinner dance floor back in play after a long hiatus 💃🕺#ARA23
Dr Irwin Lim retweeted
Replying to @DamanLangguth @_connectedcare
And then we end up with *FEAR syndrome* = Fear of an Elevated ANA Result.
The number of people, mainly women, walking around with mislaid concerns they have *pre-SLE* etc or getting repeat after repeat ANAs is a problem, I feel for them.







































