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Anna Cook (@akcook4) profile picture

Anna Cook

@akcook4

@UABMSTP student in the Arrant Lab studying FTD 🧠 Dog mom, equestrian, gamecock fan #meded #doubledocs #endFTD

researchgate.net/profile/Anna-Cook-2
Joined September 2021
  • Tweets59
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  • Followers199
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Photo by Anna Cook (@akcook4)Photo by Anna Cook (@akcook4)Photo by Anna Cook (@akcook4)Photo by Anna Cook (@akcook4)Photo by Anna Cook (@akcook4)Photo by Anna Cook (@akcook4)Photo by Anna Cook (@akcook4)Photo by Anna Cook (@akcook4)Photo by Anna Cook (@akcook4)Photo by Anna Cook (@akcook4)
Had a great time at my last SfN of my PhD! I really appreciated all the insightful discussions at my poster and learned so much at all the talks! @SfNtweets #SfN24
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
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At SfN? Stop by posters 119 and 120 this afternoon to hear about how Carboxy-terminal modifications on progranulin can improve AAV-progranulin gene therapy!
Image from Stephanie Fox, PhD (@Stefnf0x)
Image from Stephanie Fox, PhD (@Stefnf0x)
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Stop by my poster tomorrow to hear about how progranulin insufficiency influences inflammation in response to TDP-opathy! October 6th from 8-12, poster C13! #sfn2024
Image from Anna Cook (@akcook4)
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Our paper on cryptic splicing-controlled protein expression, which we hope will inspire safer and more adventurous gene therapy approaches for ALS and FTD, has been published in @ScienceMagazine science.org/doi/10.1126/scie…
Creation of de novo cryptic splicing for ALS and FTD precision medicine

Creation of de novo cryptic splicing for ALS and FTD precision medicine

Loss of function of the RNA-binding protein TDP-43 (TDP-LOF) is a hallmark of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Here we describe TDP-REG, which exploits the...

science.org
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I had such a great time at the @isftd conference! It was wonderful learning about clinical and basic research, and everything in between. I’m so thankful for the opportunity to present my research and connect with new and old friends! #isftd2024
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
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🏆 @GamecockWBB ARE YOUR 2024  NATIONAL CHAMPIONS 🏆 #NationalChampionship
Image from NCAA March Madness (@MarchMadnessWBB)
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Me and the girlies after finishing MD-PhD/residency/fellowship/postdoc
Image from Sanjee Baksh (@S__Baksh)
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My favorite @SfNtweets so far! I saw so much amazing science, gave my first nanosymposium talk, and spent time with so many new and old friends.
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
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Anna Cook retweeted
FrattaLab (@FrattaLab) profile picture
FrattaLab@FrattaLab16 Nov 2023
Want to deliver gene therapies broadly, but activate them only in diseased neurons? TDP-REG "hacks" TDP cryptic mis-splicing to drive expression only WHEN and WHERE needed! Less toxicity, wider therapeutic window, new options for sporadic ALS therapies. biorxiv.org/content/10.1101/…
Creation of de novo cryptic splicing for ALS/FTD precision medicine

Creation of de novo cryptic splicing for ALS/FTD precision medicine

A system enabling the expression of therapeutic proteins specifically in diseased cells would be transformative, providing greatly increased safety and the possibility of pre-emptive treatment. Here...

biorxiv.org
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If anyone is up early at SfN tomorrow, come check out my talk at 8:30! I’ll be talking about my mouse model to study how progranulin insufficiency is related to TDP-43 pathology!
Image from Anna Cook (@akcook4)
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I loved being able to attend the @_BrightFocus Alzheimer’s FastTrack! The talks were fantastic and I was thrilled to be able to connect with so many peers and mentors. Now on to SfN! 🧠
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
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🔬Andrew Arrant, Ph.D., and Briana De Miranda, Ph.D. have been selected as recipients of The American Parkinson Disease Association!🧠 APDA allocates $1.975 million for groundbreaking PD research in 2023-2024! 🧪 Read more: go.uab.edu/46sRkrr
Image from UAB Department of Neurology (@uab_neurology)
Image from UAB Department of Neurology (@uab_neurology)
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Many of our Live Like Lou emerging ALS investigators attended an ALS research conference in Italy last week. We were proud to sponsor this conference which focused on TDP-43 function and dysfunction in disease.
Image from Live Like Lou (@LiveLikeLou4)
Image from Live Like Lou (@LiveLikeLou4)
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So grateful to have been given the opportunity to present my research at the 1st Biennial Conference on TDP-43 Function and Dysfunction in Disease in the beautiful Trieste, Italy! Thank you so much @LiveLikeLou4 for sponsoring my trip to this insightful and productive conference!
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
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Anna Cook retweeted
Ayala Lab (@AyalaLab1) profile picture
Ayala Lab@AyalaLab15 Sep 2023
Just hours before the start of the 1st Conference on “TDP-43 function and dysfunction in disease” in beautiful Trieste, Italy. ⁦@ICGEB⁩. Can’t wait to see everyone!
Image from Ayala Lab (@AyalaLab1)
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Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes -- very exciting results from our colleagues in the lab of Dr. Lindsey Hayes! biorxiv.org/content/10.1101/…
Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular...

Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular...

The loss of nuclear TDP-43 localization and its accumulation in cytoplasmic aggregates are hallmarks of neurodegeneration and major therapeutic targets. We recently demonstrated that TDP-43 binding...

biorxiv.org
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Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin biorxiv.org/content/10.1101/…
Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated...

Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated...

Progranulin (PGRN) haploinsufficiency is a major risk factor for frontotemporal lobar degeneration with TDP-43 pathology (FTLD- GRN ). Multiple therapeutic strategies are in clinical development to...

biorxiv.org
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Interested in a researcher position? Apply now to the Hernandez lab! We’re looking for people at all levels! Reach out here or at [email protected] uab.taleo.net/careersection/…
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Wonderful group photo from the ALS and Related Motor Neuron Diseases Gordon Research Conference (also featuring the famous GRC 🐄)! @GordonConf #ALS #MND #GRC 🧠🧪⚕️🏔️🌞🌺🇨🇭
Image from Puja R. Mehta 🧠🩺🧪💙 (@DrPujaM)
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Incredible time in Les Diablerets, Switzerland at the #ALSGRC! I’ve learned so much and have really enjoyed getting to know my peers and talking about my latest data!
Image from Anna Cook (@akcook4)
Image from Anna Cook (@akcook4)
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