Computational cancer genomics
Genome Institute of Singapore
Joined April 2010
- Tweets510
- Following48
- Followers221
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Anders J. Skanderup retweeted
✨Highlighting a @CD_AACR Special Issue Commentary for #AACR24: Precision Endpoints for Contemporary Precision Oncology Trials - by Regina Hoo, @drkevin_chua_lm, @pankajpanda86, @anders_js, & @danieltanmd doi.org/10.1158/2159-8290.CD…
Anders J. Skanderup retweeted
Really clever approach to help understand the impact of broad copy number changes: Cancer aneuploidies are shaped primarily by effects on tumour fitness nature.com/articles/s41586-0…
Anders J. Skanderup retweeted
Can AI help predict pancreatic cancer earlier? nature.com/articles/s41591-0… and hms.harvard.edu/news
Anders J. Skanderup retweeted
Go cBioPortal ! Lots of new features for easy analytic access to cancer genomics, proteomics and more. Make your own discoveries on community-provided cancer data and analysis tools.
Come learn about cBioPortal at #AACR2023: Talks on Saturday by @NikolausSchultz at 8:30 AM in Room W224 (#NCIITCR session) as well as by Tali Mazor in Room W311 at 8:45 AM (@AACR Project GENIE session), a poster on Tuesday morning, and a booth in the exhibitor space (#1943).
Anders J. Skanderup retweeted
PUREE is a weakly supervised machine learning algorithm that can accurately infer tumor purity from bulk tumor gene expression data: doi.org/10.1038/s42003-023-0… @anders_js, @RevkovEgor
Anders J. Skanderup retweeted
Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵nature.com/articles/s41586-0…
Anders J. Skanderup retweeted
#Fluoxetine (#Prozac) changes so many genes in so many brain regions. Mechanism(s) of action are dizzyingly complex, but some promising themes emerge👇. Long-term collab with @meaneylab et al. Large integrative omics study heroically led by @braincrank_nr. @astar_gis #depression
Ever wondered how the 'happy pill' Prozac impacts the brain? We did too!
Delighted to share our study on the effects of fluoxetine (Prozac) on 27 different rodent brain areas. Paper is out in Molecular Psychiatry & available for free reading. nature.com/articles/s41380-0… A thread 👇🏾
Anders J. Skanderup retweeted
Singapore scientists develop AI-based method to identify cancer mutations buff.ly/3pSJLaf
Anders J. Skanderup retweeted
To update the classification system for #colorectal #cancer, the team analysed 373,000 #singlecells from 141 #tumour samples collected frm 63 patients in SG, BE, S KR.
Read: clinicalresearchnewsonline.c…
Anders J. Skanderup retweeted
1 of the deadliest cancers with diverse etiological factors worldwide. We found unprecedented genomic diff. segregating distinctively across ethnicities & stressed the importance of differential disease biology & management in HCC across ethnicities.
thno.org/v12p4703.htm
Anders J. Skanderup retweeted
Our recent preprint trying to explore the tricky question of “blood microbiome”! Great work by an amazing intern in the lab @cedriccstan guided by @minghao_chia biorxiv.org/content/10.1101/…
Is there a human blood microbiome? We unpack and address this existing controversy in our latest preprint (biorxiv.org/content/10.1101/…). Read on to find out more!
Anders J. Skanderup retweeted
VarNet, a weakly supervised #deeplearning model for somatic #VariantCalling in cancer that does not require human-engineered features or heuristic filters
#CancerResearch by @anders_js @kiran__chari et al.
go.nature.com/3opGfDM
Anders J. Skanderup retweeted
‼️ OUT TODAY @NatureGenet
📰 Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
🧑🏿🤝🧑🏼 @iaintan_mdphd @shyam_lab @astar_gis and colleagues
👇🏿
go.nature.com/3bI7ZA8
Anders J. Skanderup retweeted
Those signatures that were reported in that amazing 18k WGS analysis paper in Science yesterday? They can all be browsed on the amazing Signal resource portal! signal.mutationalsignatures.…. 😎
Anders J. Skanderup retweeted
Effective drug combinations in breast, colon and pancreatic cancer cells. 2025 drug combinations vs 125 cancer cell lines 😮nature.com/articles/s41586-0…
Anders J. Skanderup retweeted
Wonderful portal that enables exploration of the phenomenal Hartwig metastatic cancer WGS/RNAseq cohort.
Pleased to announce our novel catalog interface of the Hartwig database with whole genome sequenced tumor genomes: catalog.hartwigmedicalfounda…. Currently more than 5,000 patients, including treatment and response data. Plus RNA-seq data for more than half of the patients.
Anders J. Skanderup retweeted
Collaboration with Sjoerd van Hagen, Sander Rodenburg and Elena Garcia Lara @TheHyveNL and Augustin Luna @canninl - more to come as CPTAC enters its next phase. Go proteomics in cancer profiling!
We added several new studies from @NCItreatment's Office of Cancer Clinical Proteomics Research CPTAC project, with protein and phospho-protein levels from 892 samples across 7 cancer types. Thanks to @TheHyveNL for the curation help.
Anders J. Skanderup retweeted
Excited that our paper is online! Highlights how pervasive lineage transition occurs at a transcriptomic level in T790M neg resistance, suggesting the potential for tissue-based integrative analysis to forecast resistance trajectories in EGFR M+ NSCLC. clincancerres.aacrjournals.o… – at Central Region, Singapore
Anders J. Skanderup retweeted
New paper by @anders_js @GuanhuaPeterZhu @astar_gis shows that nucleosome-dependent degradation and 6 regulatory regions are predictive of #circulating #tumour #DNA burden throughout #cancer #progression
#CancerResearch @NatResCancer
go.nature.com/3uSbKYl
Anders J. Skanderup retweeted
Excited for our new paper out today with @metasub colleague @NiranjanTW in @NatureMedicine "Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment." nature.com/articles/s41591-0… with combined @nanopore and @illumina reads for mapping.