@andimscience

Quantitative immunology & biological physics. Q-Immuno Lab PI @iit_ucl & @ucl_ipls past: Lewis-Sigler Fellow @Princeton, PhD @ENS_ULM Also @qimmuno.bsky.social

 London, UK
qimmuno.com
Joined February 2014
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When comparing clusterings, what makes a better solution? In a new preprint, I describe homogeneity–parsimony curves as a means to quantify the underlying trade-off. Think of it as an ROC curve, but for clustering validation. arxiv.org/abs/2607.20799

External Clustering Validation by the Homogeneity-Parsimony Trade-off

Scalar metrics are often used to evaluate clusterings against known classes, but they can obscure a fundamental trade-off: clusterings should be informative about class labels while avoiding...

arxiv.org
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One month until London Q-Immuno Day 2026! 🧬💻 Join us on May 8th for interdisciplinary discussions at the intersection of theory, computation and immunology. 🥳 More details and free registration at: qimmuno.com/ldnday/
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Andreas Tiffeau-Mayer retweeted
Malcolm Sim@mjwsimMar 6
The Sim lab has been hard at work and we’re proud to present our first paper. We developed new methods to study peptide:KIR interactions. Congratulations to star postdoc Tanusya Murali who led the project. biorxiv.org/content/10.64898…
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How different are self and nonself? This is a central question in immunology. In our latest work just published in @PRX_Life we demonstrate that at the peptide-level statistical differences between host and pathogen proteomes are minor
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An important implication for cancer treatment is that neoantigens that are just one mutation from self are not strange antigen at all, as sometimes thought.
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More broadly, these findings might also help inform emerging protein design approaches to reduce unwanted immunogenicity
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Excited to share the latest preprint from the lab "Fluctuating environments are sufficient to drive substantial variability in species abundance across locations" now up on arXiv arxiv.org/abs/2603.02403 🎉
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Our work on these questions has been motivated by our experimental findings uncovering substantial variation in the human immune repertoire across blood and tonsils. doi.org/10.1016/j.immuni.202…
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Watch out for future work in which we ask: how much spatial variability in the immune repertoire can be explained by localised clonal expansions?
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If you're at @britsocimm Congress, come catch three talks today with updates about our research!
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Later on I will give an invited talk in the session "AI driven insights into immune responses: vaccines, infections, and disease" laying out a vision for combining AI with TCRseq to study human immunity
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Looking forward to connecting with many of you!
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