@BiophysJ

Biophysical Journal, the premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research.

 Rockville, MD
biophysj.org
Joined August 2015
  • Tweets3.6K
  • Following306
  • Followers6.4K
71Media
Special issue call for papers: Fifty Years of Protein Dynamics: Celebrating Andy McCammon and the Evolution of Computational Biophysics. buff.ly/1nKMEkp
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#OPENACCESS: Red blood cells are like commuters at a busy intersection! Their shape, travel history & the vascular road map determine whether they linger or take a different route. buff.ly/RldDpIv

Red blood cell positional history, sphericity, and network architecture influence lingering and...

The transport and distribution of red blood cells (RBCs) through microvascular networks is central to diverse applications in drug delivery, tissue engineering, and the study of pathological mechan...

cell.com
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#OPENACCESS: Endogenous and exogenous actin modifications alter F-actin network architecture and mechanics by charge redistribution. Peter Nietmann, Susanne Stenz, Kevin Kaub, Andrejus Suchenko, Mohan K. Balasubramanian, and Andreas Janshoff. buff.ly/n9HkaNl

Endogenous and exogenous actin modifications alter F-actin network architecture and mechanics by...

Mammalian actin comprises six highly conserved isoforms that, despite their near-identical amino acid sequences, form filament networks with remarkably diverse structural and viscoelastic properties....

cell.com
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Special issue call for papers: Genome Organization: Integrating Mathematics, Physics, and Computation for Advances in Biology and Medicine. buff.ly/egyffUr
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Special issue call for papers: The Past, Present, and Future of Muscle Biophysics. buff.ly/JReFoak
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#OPENACCESS: A new framework, which also accounts for condensate motion, to correctly determine if a molecule is inside the condensate or in the surroundings. Test your system now! buff.ly/G42Mn6x

A single-particle tracking framework for quantifying intracellular partition free energies

Biomolecular condensates are membrane-less organelles that locally enrich specific molecules at spatial sites. A central challenge is determining the physical parameters of individual condensates, as...

cell.com
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Study combines agent-based simulations with coarse-grained thermodynamic analysis to reveal how molecular motor activity drives active asters to reorganize into bundle-like structures, illustrating how mesoscopic architecture shapes mechanical response. buff.ly/HPzHQJH

Contractile to extensile transitions and mechanical adaptability enabled by activity in cytoskele...

Cytoskeletal network architecture is crucial for determining emergent morphology and dynamics, particularly in processes such as stress fiber nucleation, where cells respond to mechanical cues....

cell.com
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Special issue call for papers: Stephen H. White: In Memoriam. buff.ly/n1Asc5j
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Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: buff.ly/q6m86fo

Rocking without a Tune: A 3D Picture of How Reptiles Hear

The sense of hearing is critical for predator detection and communication across the animal kingdom. Vertebrate hearing organs are incredibly diverse, but all rely on mechanosensory hair cells...

biophysics.org
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#OPENACCESS: Hypoxia-responsive HIF-1α-dependent RhoA signaling promotes motility and aerotaxis in polyaneuploid PC3 cancer cells with increased nuclear rounding. Noreen Hosny, Shengkai Li et al. buff.ly/SXVS3jN

Hypoxia-responsive HIF-1α-dependent RhoA signaling promotes motility and aerotaxis in polyaneuploid...

Most cancer deaths result from metastasis, yet only a subset of tumor cells can complete this process. Polyaneuploid cancer cells (PACCs), which arise via endoreplication under stressors such as...

cell.com
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Beta cells don’t solo—they play as an orchestra. Barać et al. explore how cellular oscillations synchronize across scales to coordinate hormone secretion. From tiny cellular rhythms to a whole-body signal: biology knows how to keep the beat. buff.ly/ZvmNEp8

Multiscale synchronization in beta cell networks: Connecting cellular oscillations to hormone...

Within the islets of Langerhans, pancreatic beta cells coordinate pulsatile insulin release that is essential for metabolic homeostasis. This coordination emerges from complex intercellular coupling...

cell.com
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#OPENACCESS: Whole-cell spatiotemporal model and multimodal data illuminate the multiscale light responses in a photosynthetic bacterium. Connah G.M. Johnson, Aaron Chan et al. buff.ly/kDBPKlF

Whole-cell spatiotemporal model and multimodal data illuminate the multiscale light responses in a...

Photosynthetic microorganisms rely on multiple central carbon metabolism pathways to adapt to fluctuating light and energy availability across diel cycles. Mechanistic insight into the regulatory...

cell.com
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Special issue call for papers: Biophysics of Membrane Reactions in the Brain. buff.ly/oxSWx8e
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Flexible proteins are molecular yoga masters—twisting through ensembles of conformations rather than holding one pose. Rodriguez et al. ask the big question: how well can our models predict this molecular flexibility? buff.ly/vJV3VRC

Conformational ensembles of flexible multidomain proteins: How close are we to accurate and...

Multidomain proteins connected by flexible linkers populate conformational ensembles that are challenging to characterize using conventional structural biology methods. In domain-linker-domain...

cell.com
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How much force does it take to pull an integrin apart? New study reveals a high mechanical threshold required to separate α5β1 integrin transmembrane domains, uncovering a “ratchet-like” role underlying inside-out signaling. buff.ly/wOELmlg
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#OPENACCESS: Snapshots of internal protein crystal architecture at the nanoscale. Shervin S. Nia, Ambarneil Saha, Jung Cho, Z. Hong Zhou, Peter Ercius, and Matthew Mecklenburg. buff.ly/radC1JS

Snapshots of internal protein crystal architecture at the nanoscale

Macromolecular crystallography has historically inferred models of internal crystal architecture from reciprocal-space measurements of Bragg reflections. Nevertheless, direct real-space visualization...

cell.com
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#OPENACCESS: An alteration in the binding-unbinding interaction mechanism in a protein-specific condensate system impacts the exchange dynamics, aging, and size distribution of condensates—revealed by simulations. buff.ly/mD1Owam

Multi-step binding-unbinding pathways govern properties of biomolecular condensates

The interactions among condensate-forming biomolecules dictate both the specificity and properties of these condensates, including their fluid-like nature and material exchange dynamics among...

cell.com
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#OPENACCESS: An energy-based mathematical model of actin-driven protrusions in eukaryotic chemotaxis. Samuel W.S. Johnson, Maddy Parsons, Ruth E. Baker, and Philip K. Maini. buff.ly/7orPKNr

An energy-based mathematical model of actin-driven protrusions in eukaryotic chemotaxis

In eukaryotic cell chemotaxis, many cells extend and retract transient actin-driven protrusions at their membrane that facilitate both the detection of external chemical gradients and directional...

cell.com
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Special issue call for papers: Fazly Ataullakhanov: In Memoriam. buff.ly/wIX4Leg
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Tumor cells have a memory—and hypoxia leaves receipts. Sadhu et al. show that how long cells experience low oxygen can shape their future invasive behavior. The past may literally steer the next move. buff.ly/uCgDBVg

Phenotypic memory of hypoxic exposure duration drives tumor invasion dynamics

Cancer cells in hypoxic environments often proliferate less but exhibit enhanced migration relative to their normoxic counterparts. Recent in vitro and in silico studies have characterized the role...

cell.com
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