@brianlamx

A mad scientist.

 Cambridge, England
Joined March 2017
  • Tweets219
  • Following144
  • Followers192
3Media
Our latest paper about the genetics of childhood obesity is now published online! @IMS_MRL nature.com/articles/s41588-0…
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Not the main author but glad to see this paper out! Cav3.1 is a neuronal leucine sensor that mediates satiety and weight ... @IMS_MRL @blouetlab sciencedirect.com/science/ar…
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Our latest paper on cross-species effects of MC3R mutations is out: sciencedirect.com/science/ar…
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Genetic impairment of ketone body signalling is a prevalent contributor to human metabolic dysfunction medrxiv.org/content/10.1101/… Working with our great collaborators at Pfizer we have uncovered a common genetic contributor to metabolic ill health/

Genetic impairment of ketone body signalling is a prevalent contributor to human metabolic dysfun...

Emerging evidence that circulating levels of key metabolic intermediates are sensed by a range of G-Protein Coupled receptors (GPCRs) is providing critical new insights into the control of systemic...

medrxiv.org
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Thank you to our Program Committee Co-Chairs, @shyam_lab and @JayShin from @astar_gis for hosting the 2025 HCA General Meeting, and to everyone involved in #HCA2025GM. It has been a truly inspirational meeting.
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📢 Huge thanks to my amazing coauthors @gkcdowsett, Lukas Steuernagel (@MPI_Metabolism), & @brianlamx, and to our senior authors @GilesYeo & Jens Brüning. Couldn’t have done this without you! 🙌 (7/)
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HYPOMAP: A breakthrough in understanding metabolic health by researchers @IMS_MRL and @MPI_Metabolism, providing an unparalleled view of the brain’s appetite centre & helping to accelerate development of therapies for obesity and diabetes. @Nature mrl.ims.cam.ac.uk/news/mappi…
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Our latest effort in mapping the human hypothalamus: nature.com/articles/s41586-0… @IMS_MRL @MPI_Metabolism @gilesyeo @gkcdowsett @JohnTadross

A comprehensive spatio-cellular map of the human hypothalamus

Nature - HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.

nature.com
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Brian Lam retweeted
Giles Yeo@GilesYeo5 Feb 2025
I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism nature.com/articles/s41586-0…

A comprehensive spatio-cellular map of the human hypothalamus

Nature - HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.

nature.com
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So cool! A Drosophila computational brain model reveals sensorimotor processing | Nature nature.com/articles/s41586-0…

A Drosophila computational brain model reveals sensorimotor processing

Nature - We create a computational model of the adult Drosophila brain that accurately describes circuit responses upon activation of different gustatory and mechanosensory subtypes and generates...

nature.com
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Many opportunities to undertake an MPhil or PhD at @IMS_MRL (first webpage being temporarily and kindly hosted by our friends at @MRC_Epid while we fix our own) mrc-epid.cam.ac.uk/study-ims… postgraduate.study.cam.ac.uk… postgraduate.study.cam.ac.uk… postgraduate.study.cam.ac.uk…
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Great to see this out! Variant function, population genetics and animal models investigating the role of LXR alpha in liver health! Thanks to co-first author @MilanMuso, my PhD supervisor @StephenORahilly and many collaborators! @IMS_MRL @NatMetabolism nature.com/articles/s42255-0…

Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver...

Nature Metabolism - LXRα is highly expressed in hepatocytes, where it regulates cholesterol abundance and stimulates lipogenesis. The authors provide evidence in humans and mice that impaired...

nature.com
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Biospecimen research and the law | Science science.org/doi/10.1126/scie…

Biospecimen research and the law

In the well-known case of Henrietta Lacks, cells from her tumor were taken without consent and used more than 70 years ago to create the first immortal human cell line (“HeLa” cells). That event led...

science.org
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Winning researchers unlocked GLP-1 drugs for obesity | Science science.org/doi/10.1126/scie…

Winning researchers unlocked GLP-1 drugs for obesity

Award recognizes individuals whose work best underpins the Science Breakthrough of the Year

science.org
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Super excited to see this out! Many thanks to all the authors!
IMS Epidemiology, University of Cambridge@imsepidemiology4 Apr 2024
Rare gene variants identified by @ZhaoDylan and @The_MRC colleagues have the largest impacts on obesity risk discovered to date. The BSN & APBA1 variants are among the first for which increased risk of obesity isn't observed until adulthood. mrc-epid.cam.ac.uk/blog/2024… 🧵(1/6)
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Rare gene variants identified by @ZhaoDylan and @The_MRC colleagues have the largest impacts on obesity risk discovered to date. The BSN & APBA1 variants are among the first for which increased risk of obesity isn't observed until adulthood. mrc-epid.cam.ac.uk/blog/2024… 🧵(1/6)
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This is the article: nature.com/articles/s41586-0…

Formation of memory assemblies through the DNA-sensing TLR9 pathway

Nature - Learning results in persistent double-stranded DNA breaks, nuclear rupture and release of DNA fragments and histones within hippocampal CA1 neurons that, following TLR9-mediated DNA damage...

nature.com
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Memories are made by breaking DNA — and fixing it nature.com/articles/d41586-0…

Memories are made by breaking DNA — and fixing it

Nature - Nerve cells form long-term memories with the help of an inflammatory response, study in mice finds.

nature.com
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Out today in @Nature - a step closer to helping women suffering from Hyperemesis Gravidarum @StephenORahilly @IMS_MRL #pregnancy #sickness nature.com/articles/s41586-0…

GDF15 linked to maternal risk of nausea and vomiting during pregnancy

Nature - Elevated circulating levels of GDF15 in pregnant women are associated with severe nausea and vomiting, and sensitivity to such symptoms during pregnancy is partly determined by...

nature.com
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Great to see this out! We think our results suggest ways to prevent this devastating condition but we need to know how people affected by Hyperemesis feel about this idea! If you have experience of pregnancy sickness please consider completing our survey redcap.link/hghope
Inst Metabolic Science-Metabolic Research Labs@IMS_MRL13 Dec 2023
Out today in @Nature - a step closer to helping women suffering from Hyperemesis Gravidarum @StephenORahilly @IMS_MRL #pregnancy #sickness nature.com/articles/s41586-0…

GDF15 linked to maternal risk of nausea and vomiting during pregnancy

Nature - Elevated circulating levels of GDF15 in pregnant women are associated with severe nausea and vomiting, and sensitivity to such symptoms during pregnancy is partly determined by...

nature.com
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