On @netflix Jan 1 2025 is the year of don’t die

Your peptides may be coming fentanyl suppliers. Anhui Renchen Technology was indicted in 2023 for supplying the Sinaloa Cartel with fentanyl precursors. Their website currently sells semaglutide and melanotan II. Of roughly 200 Chinese firms TRM Labs tracked selling fentanyl precursors, at least 50 now sell peptides. The shipments enter the US in “master cartons” mislabelled as snack food, broken up by a domestic handler and mailed on. CBP has intercepted around 400 of those operations and seized over 130,000 vials in the past year. FDA records surfaced showing two deaths, one in July and one in September, reported after people injected untested black market retatrutide.

Honeybee queens and workers share a genome, yet queens outlive the average worker by about 10-20x. The difference is almost entirely dietary. All honeybee larvae are fed royal jelly, but those destined to become workers are cut off after a few days. Queens are continually fed on it, which triggers a slew of epigenetic and developmental changes that vastly alters their physiology, reproductive capability, and lifespan.

> T cells trigger severe gut lining damage > GLP agonists directly protect against intestinal destruction > I'm going to test this on myself

my sauna protocol is pretty ridiculous > medical grade silicon > ice on face > ice on neck > ice on boys > ice on CGM > 200°F (93°C) > 20 min > 5x/wk Cooling face/neck is a hypothesis of protecting from heat induced collagen breakdown.

A new paper cites my N-of-1 as a core feature of next generation longevity science. It explains why my biomarker numbers say less than people think. I agree. Aging is a multi-scale physiological process that we can’t actually measure directly. Biomarkers are like the blind men touching the elephant; able to know a piece, but never the whole. The processes that dictate aging exist at multiple levels of biological complexity. They interact dynamically at different timescales, across different contexts, and along their own trajectories. Aging manifests differently among people, but in highly nuanced and often invisible ways. The static, cross-sectional measures the field is used to can only get us so far. N-of-1 initiatives like mine can capture some of this nuance, but ultimately fails at generalizability. The authors also critique N-of-1 as able to show "responsiveness but not durability; optimisation but not causality." The challenge, so far unmet, is modelling the complexity of aging in such a way that the output is not a forecast of biomarkers, but a simulation of aging system dynamics, i.e. one’s health trajectory into the future. The most intriguing implication of such a model is an improved ability to predict how our decisions will impact us in the future. A choose your own adventure where we can predict the consequences of both our healthy and unhealthy behaviors. This is exactly what we are aiming to build. If you're into this as well, hit me up.

188k and 113k likes what do you think is going on?

A shout out to a few people in the longevity community who've been great > @biogerontology collaborative and helpful > @geochurch is an awesome human > @davidasinclair welcoming and open > @aubreydegrey friendly and positive > @prof_horvath chill and curious > @DrMorganLevine generous and rigorous

Rapamycin was the undisputed king of longevity drugs. I broke ranks and stopped taking it because my extensive biomarker data showed a mixed story. Cool to see two years later that skepticism is in the peer-reviewed literature.

I didn’t say that What I said: first time in 2,000 years, we're having a fresh conversation about life & death. Not abstract debate, but practical things bc radical life extension is at the doorstep. That means meaning, purpose, spirituality and culture are up for grabs.

Maintaining health during 10 days on the road > to washington dc speaking with politicians > america by design launch > @drmichaellevin lab deep dive > @Ginkgo AI automated biology lab > tobi lutke car racing

I now live my life expecting to thrive for hundreds of years, if not more.