@constantine_sci

Making every day in lab as unique as every single cell | @shaleklab | Harvard-MIT @mit_hst | @HertzFoundation Fellow | @NSFGRFP Fellow

Joined April 2020
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Out today in @CellCellPress! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)
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35th Annual Arias Symposium coming up soon on 12/2! Register for some fantastic speakers and liver community :) alfevents.org/ariassymposium…
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Apply to 2026 yeast display course from @ipiproteins! I did last year's - incredibly knowledgeable and helpful instructors, lovely community, fantastic one-week speedrun to start using yeast display yourself. A very enriching experience 🥁✨ Due Mar 30 proteininnovation.org/yeast-…

2026 Yeast Display Technology for Antibody Discovery

A five-day course in June 2026 combining lectures and hands-on laboratory sections to train participants in the core principles of yeast display technology.

proteininnovation.org
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Constantine Tzouanas retweeted
Cell@CellCellPressJan 22
The new issue is out! 👉cell.com/cell/current On the cover, Tzouanas et al. show how environmental stressors like high-fat diets challenge the social contract unifying cellular citizens, pushing some cells to prioritize their own survival over collective community goals.
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Incredible to see our work on @CellCellPress cover! Environmental stresses like high-fat diets➡️cellular communities whose past histories & present neighbors shape future disease progression & cancer outcomes (with Akira-inspired Easter eggs too!). Appreciation to @TeamSciStories
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Link to X-planation summary of the paper xitter.cf/constantine_sci/status…
Constantine Tzouanas@constantine_sci22 Dec 2025
Out today in @CellCellPress! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)
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And link to the paper itself cell.com/cell/fulltext/S0092…

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Environmental stresses, such as a high-fat diet, disrupt liver cell balance by promoting pro-survival, developmental, and regenerative programs while impairing key tissue functions. These stress...

cell.com
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Constantine Tzouanas retweeted
Cell@CellCellPress23 Dec 2025
Now online! Hepatic adaptation to chronic metabolic stress primes tumorigenesis dlvr.it/TPynWf

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Environmental stresses, such as a high-fat diet, disrupt liver cell balance by promoting pro-survival, developmental, and regenerative programs while impairing key tissue functions. These stress...

cell.com
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Much appreciation & acknowledgement to all involved - co-first authors @drjessicashay @LiverQuant and co-senior authors @WGoessling @ohyilmaz @shaleklab, and many more who enabled this work @MIT_IMES @broadinstitute @kochinstitute @ragoninstitute @harvardmed @BrighamWomens (13/n)
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That’s all for now, folks – see here for a link to the paper itself! (fin/n) cell.com/cell/fulltext/S0092…

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Environmental stresses, such as a high-fat diet, disrupt liver cell balance by promoting pro-survival, developmental, and regenerative programs while impairing key tissue functions. These stress...

cell.com
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