@corsellos

Physician scientist and oncologist at Stanford. Phenotypic drug discovery for cancer. https://xitter.cf/t.co/1GdHqno6iB

 Stanford, CA
Joined August 2013
  • Tweets181
  • Following531
  • Followers837
More than 100 emerging cancer researchers came together Sept. 16-17 for the 18th annual SCI Comprehensive Cancer Research Training Program. From precision oncology to early detection and cell therapy, the two-day program sparked scientific exchange, mentorship and collaboration.
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Pauline Funchain@FunchainMDSep 16
🎙️Amazing plenary on the evolution from pathologic to molecular characteristics to advance cancer therapy from @VivekSubbiah at @StanfordCancer’s Comprehensive Cancer Research Training Program, complete with historical perspective going back to Galileo and the Rosetta Stone 🪐🗿
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Steven Banik@StevenMBanikSep 1
Excited our ratiometric transcriptional activation (RTA) work led by @Melissa_Gray234 is out online today @CellCellPress! Measurements determine what we can discover in biology; we use RTA to turn protein abundance changes into amplified signals. cell.com/cell/fulltext/S0092…

Ratiometric transcriptional activation by protein degradation

By tethering a protein of interest to anti-CRISPR, protein degradation is transformed into amplified and programmable transcriptional outputs via Cas-based transcription factors, with sensitivity to...

cell.com
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Sarafan ChEM-H@Stanford_ChEMHAug 19
.@corsellos, Institute Scholar Nathanael Gray, Stephen Hinshaw & team solved the structure of a molecular glue in complex with its two protein partners, a discovery they hope will lead to more effective drugs to treat pancreatic cancer: brnw.ch/21x53f4

A molecular pearl in an oyster: uncovering the structural basis for potential new cancer drugs

Researchers provide a high-resolution view of new molecular glues that target and kill pancreatic cancer cells

chemh.stanford.edu
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malone
@malonehedgesAug 13
i’ve come up with a solution to the marina safeway that is sure to please everyone
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Muzumdar Lab@MuzumdarLabJul 15
Please repost! We are seeking #PostDocs to join our lab in @YaleGenetics @YaleCancer @CancerYale to study #genetic and #host drivers of #PancreaticCancer and #LungCancer. Check out our newly updated website for more lab details! medicine.yale.edu/lab/muzumd…

Muzumdar Lab

The Muzumdar Lab seeks to understand how genetic alterations cooperate with environmental and host factors to drive the progression of the most recalcitrant

medicine.yale.edu
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🚨 In @CellChemBio, Drug Discovery Awardee Steven Corsello (@corsellos) and team share the precise atomic structure of a new molecular glue that forces cancer cells to destroy their own internal nuclear gateways. cell.com/cell-chemical-biolo…

The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue

Hinshaw et al. determine the molecular basis for TRIM21 recruitment to the nuclear pore protein NUP98, showing that an induced protein-protein interface drives the potency and selectivity of the...

cell.com
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Registration is now open for the Stanford Cancer Institute Comprehensive Cancer Research Training Program (Sept 16–17, 2026). Join us for 2 days of cancer research sessions, networking, and career development. brnw.ch/21x3mDE
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What a privilege to have @TheVinodLab visit @StanfordCancer for the Breakthroughs in Cancer series. Courageous and inspiring work on PCVs in #PDAC. Thank you for sharing the journey with us!
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Excited to share our latest work, online today at Cell Chemical Biology, in which we determine the structure of the TRIM21-NPC molecular glue ternary complex to establish the molecular basis for nuclear pore destruction by an E3 ligase: doi.org/10.1016/j.chembiol.2…
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Mutation of key interface residues reduced TRIM21-NUP98 binding in vitro and in cells. This work has important implications for TRIM21 molecular glue development and potential new TRIM21 reprogramming opportunities.
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Study was led by Stephen Hinshaw, Linjie Yuan, and Md Abdullah Al Noman. Grateful for our collaborators and generous support from @DamonRunyon @TheMarkFdn @StanfordCancer @StanfordDeptMed @StanfordMed @Stanford_ChEMH
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Steven Banik@StevenMBanikMay 19
Excited to share @Melissa_Gray234's tour de force work on a new way to sense protein abundance changes. Protein loss has been a defining phenotype for biological, and more recently, small molecule discovery, and we wondered what we could discover w/ greater scale+sensitivity.
bioRxiv Synthetic Biology@bioRxiv_synbioMay 19
Ratiometric transcriptional activation by protein degradation biorxiv.org/content/10.64898… #biorxiv_synbio
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#PancreaticCancer kills more than 50,000 Americans each year. #StanDOM physician-scientist @corsellos is exploring a new approach: "molecular glue" drugs that employ a cell's own cleanup system to destroy the proteins cancer needs to survive. stanford.io/42PIi8t
Steven Corsello in a white lab coat stands in a laboratory filled with scientific equipment and supplies, such as test tubes and pipettes, organized on shelves.

ALT Steven Corsello in a white lab coat stands in a laboratory filled with scientific equipment and supplies, such as test tubes and pipettes, organized on shelves.

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Ingo Hartung@HartungIngoApr 20
Steven Costello @Stanford, one of the Nextgen Stars at #AACR26, about TRIM21 molecular glues which degrade nuclear core complex components leading to potent killing of certain pancreatic cancer cells. TRIM21-based degraders now pursued by multiple academic & industrial groups.
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Cancer Discovery@CD_AACRApr 20
Congratulations to 2026 @AACR NextGen Star @corsellos, who is speaking now at #AACR26 on his work identifying molecular glues that drive potent anti-tumor efficacy via nuclear pore complex degradation that was featured on the December cover! doi.org/10.1158/2159-8290.CD… @StanfordMed
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Cancer Discovery@CD_AACRApr 17
Congratulations to the 2026 @AACR NextGen Stars! Read about their work in this month's issue, and don't miss their presentations throughout #AACR26. doi.org/10.1158/2159-8290.CD…
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We're proud that over 60 members of the Mark Foundation community are presenting or chairing sessions at #AACR26! Headed to San Diego? We've made a list of their talks to help you plan your weekend: themarkfoundation.org/blog/m…
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Excited to see our work on phenotypic molecular glue discovery featured!
Cancer Discovery@CD_AACR15 Dec 2025
Featured on the cover this month: Defining the Antitumor Mechanism of Action of a Clinical-Stage Compound as a Selective Degrader of the Nuclear Pore Complex doi.org/10.1158/2159-8290.CD… By Linjie Yuan, Wenzhi Ji, Brendan Dwyer, Nathanael Gray, @corsellos, and colleagues @StanfordMed
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