Dallas, TX
Joined October 2016
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I made this overview of High-Grade B-cell Lymphoma using @gemeniapp . I hope you all will find it useful. g.co/gemini/share/bb5a055e96…
Jesse M. Jaso retweeted
Shift your mindset from I have to to I get to. Because your worst day is somebody else’s dream.
Jesse M. Jaso retweeted
Nobody teaches you how much of medicine is uncertainty.
You spend years memorizing the right answers.
Then you become an attending and realize your job is making good decisions with incomplete information.
Jesse M. Jaso retweeted
Gram stain of a renal cyst aspirate demonstrating many hooklets of Echinococcus.
Human echinococcosis (hydatidosis, or hydatid disease) is caused by the larval stages of cestodes of the genus Echinococcus. Echinococcus granulosus causes cystic echinococcosis and is the form most frequently encountered.
EG infections often remain asymptomatic for years before the cysts grow large enough to cause symptoms in the affected organs. The rate at which symptoms appear typically depends on the location of the cyst.
Hepatic and pulmonary signs/symptoms are the most common clinical manifestations, as these are the most common sites for cysts to develop In addition to the liver and lungs, other organs (spleen, kidneys, heart, bone, and central nervous system, including the brain and eyes) can also be involved, with resulting symptoms.
Rupture of the cysts can produce a host reaction manifesting as fever, urticaria, eosinophilia, and potentially anaphylactic shock; rupture of the cyst may also lead to cyst dissemination.
Hooklets are small, chitinous structures found on the rostellum of Echinococcus tapeworms, specifically Echinococcus granulosus and Echinococcus multilocularis.
Hooklets are a key diagnostic feature of Echinococcus hydatid cysts. They are found in the protoscolices, which are the larval heads of the tapeworm that develop inside the cyst.
These hooklets, numbering 25 to 50, assist the parasite in adhering to the intestinal mucosa of the definitive host, typically canids.
The presence of hooklets is crucial for the identification of these parasites, as they are key morphological features in diagnosing echinococcosis.
They may be the only identifiable Echinococcus structure present in some cases, especially if the cyst has ruptured.
Visualization of hooklets, either directly or with special stains, helps confirm the diagnosis of hydatid cyst disease caused by Echinococcus tapeworms.
#Fortheloveofmicrobiology #clinicalmicrobiology #microrounds #IDpath #ASMClinmicro #STEM #womeninmicrobiology #microbiologypakistan #pathbugs
Jesse M. Jaso retweeted
Dr. Weina Chen at the “ Hematopathology update series 2026 course - Integration of flow cytometry in Diagnostic Hematopathology” @UTMDAnderson
Jesse M. Jaso retweeted
Forgotten myeloma history series #1
I see PANGEA and other models to predict risk of progression in smoldering myeloma based on evolving changes in M protein and hemoglobin during follow up.
But sometimes history is forgotten. We showed this 10 years ago almost to the date. Our model is the simplest and doesn’t need calculators:
0.5 gm/dL increase in M protein occurring concurrently with 0.5 gm/dL drop in hemoglobin qualifies as high risk SMM with >80% risk of progression in 2 years.
If the marrow is 20% or more, the risk is >90% in 2 years.
@PrafulRavi1 @Leif_Bergsagel @Rfonsi1 @BloodCancerJnl
nature.com/articles/bcj20166…
Congratulations to our graduating Hematopathology Fellows, Dr. Evelyn Illori, and Dr. Sarvi Karamooz on an outstanding year! We are so proud of you both and wish you all the best ! #UTSWHemepath 🔬🩸
Jesse M. Jaso retweeted
We are very proud of our graduating fellows 🎉!!
@weinberg_olga @MDCantuMD @KoorseSharon @cyclinD1 @SarvenazKaramo3 @UTSW_Pathology
Jesse M. Jaso retweeted
These are really challenging times for academic medicine. You have to set your goals. If you want to be at the top of the field what matters is truly enduring contributions that help improve patient outcomes. Visibility, titles, fame are transient. Enduring contributions to your field or to the delivery of excellent care at your own institution will set you apart.
Success in any field needs a huge amount of hard work, talent, perseverance, and yes, luck. You need to want to do what you are doing. Passion.
Whether your efforts are in research, practice or education, what will set you apart is always hard work, talent, and perseverance. With that luck is more likely to be on your side.
Jesse M. Jaso retweeted
Thank you.
MYC rearranged ≠ Burkitt
WHO5 / ICC:
• Burkitt → MYC-R + classic biology
• DH/TH → MYC + BCL2/BCL6
• HGBL-NOS → MYC-R, no partner
• DLBCL can still be MYC+
Clinical truth:
MYC = high-grade behavior signal
Jesse M. Jaso retweeted
Not all MYC lymphomas are Burkitt.
A simple way to approach high-grade B-cell lymphoma:
1. High Ki-67 → suspect aggressive lymphoma
2. Check MYC (FISH)
If MYC rearranged:
→ Check BCL2
• BCL2 negative → Burkitt lymphoma
• BCL2 positive → Double Hit lymphoma
If MYC not rearranged:
→ DLBCL / other HGBCL
Key rule:
BCL2 positivity excludes classic Burkitt lymphoma
Morphology helps:
Burkitt = homogeneous, intermediate-sized cells
Double Hit = heterogeneous, pleomorphic
Genetics defines biology.
#Lymphoma #Hemetwitter
Jesse M. Jaso retweeted
A MUST-READ!
This is probably one of my most important papers where I try to teach how to fish rather than offer fish.
How I Read a Clinical Trial Report?
BG’s primer for Busy Clinicians.
Thank you @JCOOP_ASCO @EthicsdoctorP for the kind invitation. I hope the readers will find this useful.
ascopubs.org/doi/10.1200/OP-…
Jesse M. Jaso retweeted
Leadership should not be mediocrity dressed up in titles.
Leadership is vision, excellence, and the ability to inspire.
Titles sometimes go to people who are compliant to those who appoint them than to those who are excellent and will challenge authority when needed. But we must always seek excellence in leadership.
Jesse M. Jaso retweeted
AI can help doctors.
AI can read scans and EKGs.
But AI can never be a doctor.
Being a doctor is much more than being able to solve medical puzzles more accurately than humans.
Each patient is a unique individual who needs individualized care and counseling especially for serious illnesses. Many need experts. We should not confuse the value of AI to solve unmet needs (shortage of doctors) or improve how doctors can work with the limitations of AI on functioning as a doctor.
BBC Published an article.
AI chatbots are becoming a real front door for health advice, but new evidence says human-AI conversation breaks their medical accuracy far more than most people realize.
The problem is not that these systems always fail when they see a full, neatly written case, because in controlled testing they reached about 95% accuracy.
The problem is that real people give messy, partial, distracted symptom descriptions, and in that setting accuracy dropped to about 35%
In the area of medical advice, a tiny wording change can flip advice from “rest at home” to “go to hospital now,
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bbc .com/news/articles/clyepyy82kxo
Jesse M. Jaso retweeted
Especial médicos🩺⚕️🏥👨🏻⚕️👩🏻⚕️.
Os dejo esta carta en JAMA. Se la pondré a mis alumnos en la próxima clase:
He elegido estas frases :
👇🏻⏰
«La medicina puede tener un significado extraordinario. Pero no puede sustituir el estar presente en tu propia vida. El mundo puede necesitarnos como médicos. Pero las personas que nos aman nos necesitan como nosotros mismos. Y ese es el rol que nadie más puede llenar.»
«La residencia refuerza la lección de que las instituciones están diseñadas para perdurar más allá de los individuos. En cambio, las familias no.»
«Creo en formar a la próxima generación. Creo en el significado de este trabajo. Lo que ha cambiado es mi disposición a absorber el desgaste sin cuestionarlo.»
«Ya no estoy dispuesta a seguir posponiendo la vida. La medicina exige mucho. Y nosotros damos profundamente. Pero no puede tomarlo todo.»
«El significado de mi trabajo es profundo. El significado de mi presencia en casa es irremplazable.»
Jesse M. Jaso retweeted
I’m really proud @BloodCancerJnl is doing so well. We are getting a huge number of high quality submissions. It’s gratifying to take a journal from inception to this level in 15 years.
Our goal is to be #1.
@SagarLonialMD @Mohty_EBMT @n_gangat nature.com/bcj/
