In essence, we understood it too late, dismissed it too soon, sleepwalked into oblivion. https://teapaw.org/t.co/5uIrBZXB7C Pathologist and investor
Porto , Portugal
Joined May 2010
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Daniel R P de Melo retweeted
La Fiscalía Europea (EPPO) en Madrid 🇪🇸 ha abierto una segunda investigación por un posible fraude relacionado con los fondos de la UE destinados a la renovación de la línea ferroviaria de alta velocidad Madrid-Sevilla, en la que se produjo el trágico accidente la semana pasada.
The EPPO in Madrid 🇪🇸 has opened a second investigation into possible fraud affecting EU funds allocated to the renovation of the Madrid – Seville high-speed railway line, on which the tragic accident occurred last week in the province of Toledo.
More: eppo.europa.eu/media/news/sp…
Daniel R P de Melo retweeted
Yet another correct prediction by AI 2027. In the scenario, speedup from AI is 2x around Dec 2026. I don't like that progress is roughly going as fast as AI 2027 predicted, given that in the scenario, ASI happens in 2027.
(my actual median for ASI is 2028/2029)
Daniel R P de Melo retweeted
This report shares our three subjective conclusions about risk:
1. We believe that, as of Oct 2026, the pace of capability growth on well-specified tasks is likely about 2x what it was from Mar 2024 to Oct 2025. We’re highly uncertain and would not be surprised by 1.3x–3x.
Daniel R P de Melo retweeted
O Metro vai ter, hoje, serviço reforçado, naturalmente.
Pedimos desculpa pelo equívoco, mas não se preocupem, o estagiário já foi repreendido. 😜
🐉 O Metro vai ter, hoje, a partir das 18h30 devido ao @FCPorto 🆚 @estorilpraiasad, às 20h30, no Estádio do Dragão.
#futeboldemetro
Daniel R P de Melo retweeted
Introducing Reality-Aware Rendering in @Simulon, a completely new way to create with the real world.
Place neural assets with your phone and act out the scene. When you stop recording, Simulon renders the take, reading everything in it (what you do, what you say and the place around you), and your assets respond to all of it.
The final is regenerated from your recording: a new performance of the scene, not a copy of the footage.
Available now on iPhone. Coming to Android soon.
Daniel R P de Melo retweeted
How on earth did this happen:
The Indian certificate authority (CA) eMudhra had one job (well, two):
1. Create secure, 384-bit private keys
2. Store these securely and do not leak them
Well, eMudhra chose private keys between 1 and 256 (the numbers!!) and called it a day. WTF
Daniel R P de Melo retweeted
Cancer patients with the same diagnosis often have very different tumor biology.
Molecular testing can reveal underlying differences, but that's slow and expensive.
Introducing Holon-S1, our platform to predict genes and biomarkers from routine pathology slides.
• beats two other models at predicting spatial gene activity in a controlled comparison
• has identified potentially novel biomarkers in breast cancer and colon cancer
• evaluated across 16 organ types and more than 15 scanners, using slides from both formalin-fixed, paraffin-embedded and fresh-frozen tissue.
We believe Holon-S1 has the potential to help researchers find new biomarkers in slides they already have, discover treatment targets, and bring more personalized cancer care within reach!
Daniel R P de Melo retweeted
🇩🇪 Nvidia's Jensen Huang CORNERED German Chancellor Merz on the old EU regulation playbook
"I've also heard you say that you want to find that balance between innovation and regulation.
There's nothing to regulate if the industry doesn't thrive."
Europe keeps reaching for the rulebook before the companies even get off the ground.
Writer: Lucas
Daniel R P de Melo retweeted
Can we design proteins that cut other proteins? Our de novo cysteine protease paper is out in Nature! We designed new folds that cleave peptide backbones, with activity demonstrated in mammalian cells. Paper and code 👇
nature.com/articles/s41586-0…
Daniel R P de Melo retweeted
My book comes out tomorrow, so this is the last day to qualify for the pre-order bonus: a fun 10 minute AI voice interview that gives you personalized prompts, ideas, & readings based on ideas from the book
You can order & claim the pre-order bonus here: co-existence.ai/
Daniel R P de Melo retweeted
Big news! Our new book, "Making the Modern Laboratory," is now available for pre-order. It is a stunning, 504-page hardcover book that explains how the research laboratory, and everything in it, came to be.
Did you know that the modern micropipette was invented by a German postdoc so frustrated with mouth pipetting that he ditched his lab for two days until could return with a prototype?
Or that an 18th-century scientist sewed tiny taffeta pants for male frogs to determine whether or not semen was essential for fertilization?
These stories and hundreds more are told in the book, which has a hard cloth cover and is printed in full color on Arena Natural Rough, a textured, uncoated paper made by Fedrigoni. The book is also finished with colored endpapers, thread-sewn binding, and a squared spine. It is priced at $49 and worth every penny.
Learn more and order: press.asimov.com/articles/mo…
Daniel R P de Melo retweeted
when nick told me that he had some interp breakthroughs, he was uh, underselling it. i think this may be remembered as a major moment in scientific history. news so good even eliezer will have to lower his pdoom. we can start making alignment into a 'normal science'
interpretability might be the most important scientific problem in the world right now, as I don't think we can solve alignment if we don't know what we're building. I think I have good news about it. I co-authored early work in mechanistic interpretability at OpenAI and came away pessimistic, because neural networks appeared to fold into arbitrary tangled knots. years later, I started openai's first large-scale automated interpretability project, finding about 2% of neurons legible with the primitive tools we had
with modern agentic tools and a much closer look, the picture looks totally different. the vast majority in models up to trillions of parameters are legible, and their circuits beautiful. many famous examples of tangled neurons turned out to be misunderstood. The roadblocks I expected mostly aren't there. I now think ambitious interpretability will be solved by the time we need it most, and possibly quite soon, as automated scientists keep improving. it may be a bitter lesson for interpretability: the simple thing, at absurd scale, works
already-clean.goodfire.com/
Daniel R P de Melo retweeted
and yes this is serious
from situational awareness:
We discovered a sophisticated recording device that was hidden inside one of our offices. We used our models to understand the device and where it had come from, identifying that a specific employee had planted it a few days earlier. We referred the matter to the FBI, and we’re grateful to the agents and prosecutors who moved quickly to make an arrest. The FBI’s investigation is ongoing and we will continue to support their work.
At this time, we have no indications of this individual inappropriately accessing or exfiltrating model weights, source code, or customer data. The employee was terminated.
We take protecting our technology, data, and people seriously, and as a matter of national importance. Our security program is designed to protect against a wide range of threat actors, from insider risks to cybercriminals to nation states, and this case is an example of how AI can help address these sophisticated security threats.
Daniel R P de Melo retweeted
Pacing is out the window. For it to work, every American lab needed to be on board, Mark Zuckerberg has repeatedly made it clear that he is not interested. One defection among US labs breaks it all, as the others will be forced to accelerate or get passed. Mark has a staggering amount of compute and has been all in on compute capex for years; even in the face of some investor opposition he never stopped building his infra once. He said on the the earnings call a couple of years ago that he'd rather overspend now, and potentially even be wrong, than not have the compute when he needed it for the next 10x. He's finally hitting his stride, and he is not going to slow down.
For Team Pacing to solve a defection like this, they would have needed a supportive, pro-Pacing administration that was passing capability regulations and was willing to use the power of the federal government to enforce them and bring noncompliant labs into line. They don't have any of this. In fact, it's the opposite! Mark has Trump's ear, and President Trump, Mark Zuckerberg, and Jensen are completely aligned on policy; It's full speed ahead, and if you want to pace yourself, go ahead, but don't tell anyone else what to do. This breaks Pacing.
None of this changes until 2029 at the earliest, and to me, 2029 is past the ASI window. The last election, as it turns out, really was the most important one in history.
