
Author | 6-time #1-Ranked Healthcare Analyst | subscribe here: https://xitter.cf/t.co/wztkDpP4gP and https://xitter.cf/t.co/KnI2VeUpzA
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Joined March 2009
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“You Must Get Hit by a Truck to Use It” open.substack.com/pub/thehea…
This is today - imagine what will emerge to benefit health in the next ten years.
An AI model can predict whether you’re likely to die of cancer from a single photo of your face, according to new research.
sciam.com/article/can-ai-pre…
This is refreshing from a CEO, and an accurate take.
One month (or so) on @X , a platform unlike any other. Energy, speed, smarts and stupidity.
-The best thing in BioX - Rapid and divergent takes on new clinical data, on balance usually right..wisdom of crowds
-The worst thing on BioX - Shameless replies and reposts pumping your own book, praying for M&A about your favorite name, plane stalking…do people actually think this is how a real drug company or serious investor makes decisions? Maybe it just makes you feel like you have some agency, then ok.
One of my brothers started Google Ventures. While there, he called out Theranos super early. Holmes clapped back saying GV never looked at it. My brother replied with receipts. Then history happened. Kinda awesome.
A few readers have taken me to task for “missing the point of the film,” which is apparently that Elizabeth Holmes is unknowable and everything is ambiguous. Here’s my response: She went after Tyler Shultz and Erika Cheung with everything she had. I was threatened with litigation on a daily basis for months on end. It was a ruthless cover-up of a breathtaking fraud, and she was at the controls. Just a little context for those who have forgotten or didn’t follow the original story. By the way, I loved the film. #BestPicture, IMO.
No one should have any sympathy for someone who knowingly put people's health, and as a result, lives at risk. She is not misunderstood. In my opinion, a monster.
A few readers have taken me to task for “missing the point of the film,” which is apparently that Elizabeth Holmes is unknowable and everything is ambiguous. Here’s my response: She went after Tyler Shultz and Erika Cheung with everything she had. I was threatened with litigation on a daily basis for months on end. It was a ruthless cover-up of a breathtaking fraud, and she was at the controls. Just a little context for those who have forgotten or didn’t follow the original story. By the way, I loved the film. #BestPicture, IMO.
The FDA requires zero proof of efficacy for "general wellness" products. No trials, no review — just vague claims. Billions wasted annually on unproven treatments. Time to revisit the law.
Too many people fall for scams, use unproven products, as their conditions worsen without seeing a doctor.
I liked it better when Mark Twain wrote it 129 years ago: “We should be careful to get out of an experience only the wisdom that is in it—and stop there; lest we be like the cat that sits down on a hot stove-lid. She will never sit down on a hot stove-lid again—and that is well; but also she will never sit down on a cold one anymore.”
Replying to @brentlsaunders
Great line: “Experience helps you recognize patterns. It can also make you see the same pattern everywhere.”
The 5 year thing is silly and said by someone with no real credibility about drug development. However, if you look at the progress in solving "unsolvable" math problems, AI is incredible. My point is, I would not underestimate the amount of impact AI will have in drug development, but timelines for clinical trials are long and the unpredictibility of biological systems is high, so his hyperbole is crazy, but directionally right. Incredible progress will be made in the next 10 to 20 years.
If you care about biotech and drug development watch this interview with Matt Gline, the CEO of Roivant, a biotech firm that is now worth $24 billion.
He talks about why he thinks predictions about AI from people like Anthropic’s Dario Amodei are overly optimistic.
“If Dario is right and I'm wrong, and he cures every disease in five years, man, are we all the winners from that outcome,” Gline said.
“I think if you work in this industry, it is very hard not to be skeptical of any of those claims. Because, and I've said this in other settings recently too, biotech is a wood chipper that like is built to like ingest souls and shred them. It's just like such a hard business that like someone comes and they're like, oh, but I've built a computer and I'm going to push a button and all of that goes away and it just works. Like that is probably not the way that's going to go.”
If a public company pays a $1 billion+ to the U.S. government for wrongdoing, a well-functioning board should demand the ceo's resignation without a parachute. If you take the pay, you take the blame.
How much would you pay a CEO who delivered a ~7% stock decline while the S&P 500 more than doubled (with dividends reinvested)?
Bausch + Lomb just paid Brent Saunders $75.5 million. #griftingfordummies
• March 6, 2023: $17.28
• Oct 12, 2026: $16.07
• Result: ~7% decline
Is there anyone that believes that Brent Saunders would leave any company if he had a chance of making money by staying? There is always a story behind a ceo resigning effective immediately. $BLCO
With every quote and interview, Bob Chapek reveals more and more why he was not the person to lead $DIS
A drug co CEO I know is now posting nearly everyday, a lot of it about AI in a transparent attempt to be relevant. The AI detection says 85% probability it is AI slop. So I guess somone on his team knows how to use AI.
Sometimes I wonder whether some CEOs in this industry have wandered out of a Tom Wolfe novel—grand pronouncements about leadership, trust and responsibility, delivered with such exquisite self-seriousness and lack of irony that the satire practically writes itself. fiercepharma.com/manufacturi…
If your product could change the world, earning the world’s trust is part of your job as CEO.
That seems to get lost in the AI debate. Leadership means taking responsibility for the safety of what you put into people’s hands.
In my industry, that responsibility is paramount. We move urgently because patients are waiting, and we have to earn confidence through testing, evidence and how we respond when something goes wrong.
I want AI to advance. CEOs need to build the trust that allows it to.
Curious how you see this. Are we asking enough of the leaders responsible for earning that trust? @AdamMGrant





