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Denic Lab (@denic_lab) profile picture

Denic Lab

@denic_lab

The Denic lab studies selective autophagy, proteostasis, tail-anchored proteins, and more! It is what it is @MCB_Harvard Account run by Vlad and students

 Cambridge, MA
deniclab.com
Joined May 2018
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  • Following118
  • Followers446
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Photo by Denic Lab (@denic_lab)Photo by Denic Lab (@denic_lab)Photo by Denic Lab (@denic_lab)Photo by Denic Lab (@denic_lab)Photo by Denic Lab (@denic_lab)Photo by Denic Lab (@denic_lab)Photo by Denic Lab (@denic_lab)Photo by Denic Lab (@denic_lab)Photo by Denic Lab (@denic_lab)
Check out Vlad's ASCB Award Essay: "Advice to a young scientist (by someone who doesn’t know how to give it)" molbiolcell.org/doi/abs/10.1…
Image from Denic Lab (@denic_lab)
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The 26S Proteasome Utilizes a Kinetic Gateway to Prioritize Substrate Degradation sciencedirect.com/science/ar…
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Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy cell.com/cell-metabolism/ful…
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Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids cell.com/molecular-cell/full…
Image from Molecular Cell (@MolecularCell)
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"Yeast waits for no man" -Vlad Denic
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Our CRISPR/autophagy/TMEM41B manuscript is finally out at PLOS Biology. journals.plos.org/plosbiolog…
CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel...

CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel...

Author summary Eukaryotic cells use autophagy to eliminate unwanted structures—such as protein aggregates, intracellular pathogens, and damaged organelles—that are too large to be handled by the...

journals.plos.org
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Visualization of Compartmentalized Kinase Activity Dynamics Using Adaptable BimKARs cell.com/cell-chemical-biolo…
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Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy nature.com/articles/s41556-0…
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The AAA+ ATPase TorsinA polymerizes into hollow tubes with a helical periodicity of 8.5 subunits per turn: biorxiv.org/content/10.1101/…
The AAA+ ATPase TorsinA polymerizes into hollow tubes with a helical periodicity of 8.5 subunits...

The AAA+ ATPase TorsinA polymerizes into hollow tubes with a helical periodicity of 8.5 subunits...

TorsinA is an ER-resident AAA+ ATPase, whose single residue deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is a highly unusual AAA+ ATPase in that...

biorxiv.org
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Very excited to share that this work with @GabrielNeurohr & @AngelikaAmon is now online in @CellCellPress! What happens if cell size increases but DNA content stays constant? "Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence" cell.com/cell/fulltext/S0092…
Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

Optimal cell function requires maintenance of a narrow range of DNA:cytoplasm ratios and when cell size exceeds this ratio cytoplasmic dilution contributes to senescence

cell.com
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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice rdcu.be/bi1u4
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Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation ... sciencedirect.com/science/ar…
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Great initiative @CdeCBo @MCB_Harvard
Oscar Hernandez Murillo (@Oahm95) profile pictureOscar Hernandez Murillo@Oahm958 Jan 2019
CdeBo19 has been an amazing experience! Club 8 students have learned so much; now they know more about biochemistry and protein engineering. I think their favorite protein might be Hsp104. Thanks, Amber, Jim and Shorter lab for the help! @ShorterLab @DaTDP43aboutFus @CdeCBo
Image from Oscar Hernandez Murillo (@Oahm95)
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Vlad Denic aka Mission Hipster!
Dyche Mullins et al. (@MullinsLab) profile pictureDyche Mullins et al.@MullinsLab16 Jan 2019
Scientist photo challenge. #7scientistchallenge 7 portraits of 7 scientists posted over 7 days. Photos must be your own. Nominated by MYSELF and nominating @ryochem. Day #7 (I fell behind): Vlad Denic, 2007 (Canon PowerShot G7)
Image from Dyche Mullins et al. (@MullinsLab)
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Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control rdcu.be/be5rV
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A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions cell.com/cell/fulltext/S0092…
A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein...

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein...

ER-associated granules foster selective protein-protein interactions dictated by the nucleotide composition of the encoding mRNA.

cell.com
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Congrats to grad student Andrew on earning a fellowship from the American Federation for Aging Research!
MCB_Harvard (@MCB_Harvard) profile pictureMCB_Harvard@MCB_Harvard7 Nov 2018
MCO Student Wins Fellowship mcb.harvard.edu/education/mc…
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CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes cell.com/cell-reports/fullte…
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A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission cell.com/cell/fulltext/S0092…
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MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins embor.embopress.org/content/…
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NUFIP1 is a ribosome receptor for starvation-induced ribophagy science.sciencemag.org/conte…
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