Molecular Neuropathology lab at UKE, Germany | Neurodegeneration, Translational Neuropathology. Opinions expressed are Dr. Sepulveda-Falla's alone.
Hamburg, Germany
Joined May 2022
- Tweets136
- Following91
- Followers128
- Likes269
Dr. Diego Sepulveda-Falla Lab retweeted
Exome sequencing of a Portuguese cohort of early-onset Alzheimer’s disease implicates the X-linked lysosomal gene GLA #neuropath
nature.com/articles/s41598-0…
Dr. Diego Sepulveda-Falla Lab retweeted
'Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between #Tauopathies'
Dmytro Morderer @DMorderer & Melissa C. Wren @NeuroWren...@RossollLab @MayoClinicNeuro #proteomics
bit.ly/3FtmpDf
Last week at the Dementia and Brain Ageing in LMICs 2024 Symposium in Nairobi 🦁🦒. We talked a little about Alzheimer's neuropathology 🧠and remember those who left us this year 😢. Thanks to Gladys E. Maestre and Raj Kalaria for the invitation, it was a great meeting!.
Right, only until recently we have been following actual leads to find a cause for Alzheimer's. By the way, that was a brief and accurate profile😀, thanks @UKEHamburg ! uke.de/english/research/news…
Dr. Diego Sepulveda-Falla Lab retweeted
Many of my papers focus on Tau and not Amyloid-beta. But I could not stand not to report that there is an A-beta predominant form of Alzheimer’s without Tau…maybe they have protective genes against tau pathology?
academic.oup.com/brain/advan…
Congratulations to Dr. Lisa @JLisaLittau for her successful thesis defense and comprehensive work in Vacular pathology of Alzheimer's disease! we are very proud of her. 🧠👩🎓🥳 #Alzheimers #PhDs
He was more than a teacher or a mentor to me. A great man, a great scientist, an imperfect human, an example, and a father. He showed us a way to follow, and a task to accomplish, I will humbly do my part in his honor. nytimes.com/2024/09/11/scien…
Thanks, @jennieerinsmith, in your words I really see the great person and scientist we lost yesterday. 💕
Best remembrance I've seen so far. Thanks @jennieerinsmith 🥲
This Post is from an account that no longer exists. Learn more
As one of many scientific children, and a longstanding collaborator of Francisco Lopera, I can only confirm this news with sorrow and restate my support to colleagues, friends, and family for what lies ahead of us.
This Post is from an account that no longer exists. Learn more
Who said preparing a grant application is boring? It is great to meet the team that will explore disease heterogeneity in the largest autosomal dominant AD families in the world! 😄 ##AAIC24 #ENDALZ @davidaguillon3 @neuroudea
I am interested in neuronal subtypes and their vulnerability in #Alzheimers, and I am enjoying the latest @manoliskellis paper. I've seen multiple tweets in the last two days, complaining about it because, a) it shows too much without saying nothing, or b) it has too much data 1/
Other examples: we can hardly keep up with the volume of published papers in any field. Peer reviewing is insufficient for really assessing the quality of high density data papers like Manolis'. Paper overproduction gets in the way of validation and reproducibility, etc.. 3/
Well, I didn't plan to, I didn't expect to, but I will be attending this year's #AAIC24. I am looking forward to enjoying all the amazing #neuropathology works by our colleagues 😀 🧠 See you there!
Excited to share our #MultiRegion #SingleCell dissection of #Alzheimers out in @Nature today
studying #Reelin in #RegionSpecific #NeuronalVulnerability, #CholineMetabolism and #PolyAmineBiosynthesis in #CognitiveResilience, #Astrocyte diversity, #Thalamus-specific #Interneurons, #scDemon for #Module analysis, and so much more.
Paper: nature.com/articles/s41586-0…
News: picower.mit.edu/news/study-a…
Website/Data: compbio.mit.edu/ad_multiregi…
Interactive website: compbio2.mit.edu/ad_multireg…
Cell Browser: ad-multi-region.cells.ucsc.e…
Code: github.com/cboix/admultiregi…
scDemon module analysis: github.com/KellisLab/scdemon
with: @Carles_Boix, @MathysHansruedi, @Leyla_Aakay, @DrLiHueiTsai, #DavidBennett, @RudyTanzi, @__ben_james__, @_JoseDavila, #KikiGalani, @NeilBBand, @NIHAging, #CureAlz and so many more amazing contributors.
Truly grateful for an amazing team and collaboration #OpenAccess #OpenScience #NeuroDegeneration
