Director, MS Center for Innovations in Care. 🧠 doctor helping people live well with multiple sclerosis. Podcast host: https://xitter.cf/t.co/POevAw4x7s Tweets ≠ medical advice

St. Louis, MO USA
Joined May 2013
NEW Podcast #GLP-1s, Weight and #Exercise in #MS Impact on inflammation & neuroplasticity! Dr. Stuve @UTSWMedCenter & Trevor @MSGym1 bit.ly/4zNjTiT🍏apple.co/4iFQH7i @narologist @jsabatino37 @C_OrejaGuevara @anneke_vdw #NeuroTwitter Sponsor: @TGTherapeutics
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Wiendl: Phase 3 REMODEL trials: #Remibrutinib reduced relapses by 31–35%, new T2 lesions by 65–70%, 3-month CDP by 20.5% (p=0.09) & 6-month CDP by 29.2% (p=0.038) vs teriflunomide. No major liver safety signal. #MSTORONTO2026
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More info on remibrutinib in REMODEL…
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Oh: Phase 3 fenebrutinib reduced slowly expanding lesion (SEL) counts by 21.5% vs ocrelizumab in PPMS and 18.3% vs teriflunomide in RMS. SEL volumes reduced 27.5% and 30.5%, respectively. Fewer patients on fenebrutinib accumulated PRLs. #MSTORONTO2026
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Ontaneda: First Phase 1 results of off-the-shelf CD19 CAR T-cell therapy (azer-cel) in progressive MS (n=26). No dose-limiting toxicities; EDSS stable/improved in 16/18 at Day 90. Early data; follow-up ongoing. #MSTORONTO2026
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Eshaghi: AI can be used in reading MRI scans for #MS including cerebral lesions, brain volumetrics, cord atrophy and cord lesions. Future development may redefine prognostic capability. #MSTORONTO2026
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Alping: Risk of inflammatory bowel disease on rituximab increased. 62% of IBD events were classified as Crohn's disease. Number Needed to Harm: 131 patients over 5 years. #MSTORONTO2026
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Varjú: Danish #MS registry shows a dramatic shift in switch from escalation strategy to early use of high efficacy treatment. No difference in PIRA outcomes between these approaches. 🤔 Controlling for all variables seems challenging…. #MSTORONTO2026
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Checkout my @ECTRIMS poster. ENHANCE study: #MS patients switching from ocrelizumab to #ublituximab had 69% reduction in wearing-off at week 24. Patients with B cells despite ocrelizumab became depleted on ublituximab. 👉bit.ly/4iycUUh #MSTORONTO2026
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Sormani: Pooled FENhance 1 and 2 RMS. Fenebrutinib compared to teriflunomide ⬇️relapses 55%, ⬇️ enhancing lesions 75% and ⬇️ new/enlarging T2 80%. Composite disability results below. #MSTORONTO2026
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Excited to arrive at @ECTRIMS in Toronto to share and learn about the latest developments in multiple sclerosis. Looking forward to real progress for people living with #MS globally. 🌎Updates to follow! #MSTORONTO2026
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Sleep fixes sleepiness. It doesn't always fix MS fatigue. New MS Living Well Pod 🎧: @RonaMossMorris @KingsCollegeLon shares what really works. bit.ly/4yXOeKG 🍎apple.co/4yB40KP #MSToronto2026 @KlausSchmierer @C_OrejaGuevara @DocforMS Sponsor: @TGTherapeutics
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Sleep fixes sleepiness. It doesn't always fix MS fatigue. New #MSLivingWell Pod 🎧 @brainboyneuro1 talks @RonaMossMorris about what actually helps you get your energy back! bit.ly/4yXOeKG 🍎apple.co/4yB40KP @Brandon_Beaber @themsguide @MSViewsandNews @MarkWebb_
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Worried your MS therapy raises your cancer risk? The long-term data may surprise you. New #MSLivingWell episode🎧Drs. Esther Melamed & Melinda Magyari; Host @brainboyneuro1 bit.ly/3TdjnKM 🍏apple.co/46HoeXF @MStranslate @MustStopMS @themsguide @MarkWebb_
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Worried your MS therapy raises your cancer risk? The long-term data may surprise you. New #MSLivingWell episode🎧Drs. Esther Melamed & Melinda Magyari; Host @brainboyneuro1 bit.ly/3TdjnKM 🍏apple.co/46HoeXF @Brandon_Beaber @MSViewsandNews Sponsor: @TGTherapeutics
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Can targeted exercise rewire the brain to improve function in #MS? Trevor Wicken @TheMSGym1 shares strategies on New MS Living Podcast. bit.ly/4zNjTiT🍏apple.co/4iFQH7i @MustStopMS @eurims @DrJNicholas @MarkWebb_
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Could #GLP1 meds like Ozempic/Mounjaro do more for people with #MS than weight loss? Reduce inflammation, neuroprotection & myelin repair? New Podcast🎧 Guest: Dr. Stuve @UTSWMedCenter bit.ly/4zNjTiT🍏apple.co/4iFQH7i @Brandon_Beaber @MSViewsandNews @MStranslate
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👏Phase 3 REMODEL #remibrutinib relapsing #MS: Superior⬇️ annualized relapse rate (ARR) & inflammatory brain lesions vs. teriflunomide. Positive trend in 3-month confirmed disability progression. Favorable safety profile with no liver safety signal. #BTKi bit.ly/4h6Douv
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#CAREGIVING for someone with #MS? 🎧 Listen in to this new episode on MS Living Well podcast with @KennethPakenham, Dan Shaul & @brainboyneuro1 bit.ly/4pBqrg2 🍏apple.co/4fNsRoc @KlausSchmierer @C_OrejaGuevara @anneke_vdw @bart_professor Sponsor: @TGTherapeutics
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