Clinician-Scientist | Inflammation, Neutrophils, Netosis, Salivary biomarkers, Proteomics, Tissue Pathogens | J. Craig Venter Institute. 🔥🦠🧬💧
La Jolla, CA
Joined October 2014
- Tweets955
- Following1.3K
- Followers2.3K
- Likes3.7K
Marcelo Freire #drInflammation retweeted
Just two doses of psilocybin administered before chemotherapy completely prevented mice from developing neuropathy
go.nature.com/4ibX56b
Inflammation: Friend or Foe? linkedin.com/pulse/inflammat… via @LinkedIn
Spiders spin webs from silk 🕸️ Neutrophils spin them from their own DNA 🧬 That's NETosis — elegant against pathogens, implicated in #lupus, #longcovid and #sepsis when it misfires. Measuring it is challenging, so made a reliable protocol ;)
New paper👉cell.com/star-protocols/full…
Marcelo Freire #drInflammation retweeted
Hundreds of scans hint at how substances such as psilocybin, LSD and ayahuasca alter connections between key areas of the brain
go.nature.com/4tzwLVX
Huge congrats to Claire Houcheon receiving the 2026 IADR STAR Fellowship! 🏆We will host her in my laboratory @JCVI to dive into #SpatialTranscriptomics . It’s an honor to support the next generation🫶 🧬@IADR
#IADR #DentalResearch #JCVI #ScienceMentorship #Research
Marcelo Freire #drInflammation retweeted
I've been sick with ME/CFS & related comorbidities for 20 years and noticed it's really hard to find any reliable info on treatment beyond pacing recommendations
So I built a treatment database for our community, covering ME, LC, POTS, MCAS, FM, SFN
thespooniverse.org/treatment…
In colon tissue of #Long Covid subjects, Spike positive regions revealed significant changes in the transcriptome.
Similar to tumor signaling and Crohn's disease gene expressions. Overall, chronic inflammation transcripts dominated these spike positive regions in LC samples.
What is persistent #SARS-CoV-2 Spike doing in gut tissue in situ?
In our new preprint, we used spatial transcriptomics, RNAscope, GeoMx DSP, and multiplex IF to investigate biopsies from #LongCOVID
The immune dysfunction happen on spike + regions of LC.
biorxiv.org/content/10.64898…
In this collaborative study funded by @polybioRF, we have detected gene signatures specific of Long covid tissue regions. Persistent SARS-CoV-2 antigen is not biologically inert in tissue, in fact super active with both immune suppression and activation.
@PutrinoLab @AmyProal
We found that Spike⁺ regions show:
• immune cell remodeling
• suppressed chemokine signalling
• epithelial stress programs
In LC tissue, these regions display transcriptional signatures resembling tumorigenesis, Crohn’s disease–associated pathways, and #chronic #inflammation
We have sequenced the microbiome of six Brazilian biomes: #Amazon, #AtlanticForest, #Cerrado, #Caatinga, #Pampa, and #Pantanal. This massive effort, led by my colleagues @Embrapa and my lab at @JCVenterInst had the goal to develop a deeper understanding of the foundation of our ecosystems. Our hope? To use this knowledge to help preserve & regenerate ecological systems that are failing.
Read the @biorxivpreprint here: 🔻
biorxiv.org/content/10.1101/…
Summer Internships ✨
This summer at #JCVI, students in #STEM are exploring science in the areas of human biology, infectious diseases, oceanography and synthetic biology. My laboratory has 7 interns and the projects range from #inflammation, #LongCovid, #tissuepathogenesis. We are lively lab that is not going to back down from what the government is doing. This is only possible due to funding from @prebysfound and @polybioRF empowering the opportunities of these young scientists and the experiments they are doing! #JCVI #UCSD #FutureScientists
🦠 #Biofilms in the Mouth impacting the whole body?
In our lab, we focus on oral pathogens with systemic implications, specially inducing chronic #inflammation. One such microbe is Aggregatibacter actinomycetemcomitans (Aa)—a key player in periodontal disease and, as our work showed, a significant colonizer of biomaterials like #titanium implants.
🔍 In our earlier study (pmc.ncbi.nlm.nih.gov/article…), we developed a model demonstrating Aa's strong preference for rough titanium oxide surfaces. Building on that, we designed a therapeutic approach to control Aa locally and systemically (pmc.ncbi.nlm.nih.gov/article…).
Biofilms can lead to microbial migration into blood vessels which can impact other tissues. Better therapeutics need to focus on tissue pathogenesis with biofilm derived microbes.
Marcelo Freire #drInflammation retweeted
Check out this new paper by @microbeminded2 @MichaelPelusoMD and colleagues describing new insights and clinical trial recommendations for "Targeting the SARS-CoV-2 reservoir in long COVID" 👇
@polybioRF
sciencedirect.com/science/ar…
Marcelo Freire #drInflammation retweeted
Over 800 million adults are now living with diabetes worldwide with more than half not receiving treatment, global analysis suggests.
On #WorldDiabetesDay, explore the data: hubs.li/Q02Yb3Fg0
ALT World map displaying the number of people with (A) diabetes and (B) untreated diabetes in 2022. Copyright: 2024 The Author(s). Published by Elsevier Ltd. CC BY 4.0.
Marcelo Freire #drInflammation retweeted
Here's our statement on the results of the 2024 presidential election:
Marcelo Freire #drInflammation retweeted
GLP-1 receptor agonists, which are effective for weight loss, can cause substantial muscle loss.
A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: hubs.li/Q02WgC490
ALT Figure showing selected key roles of skeletal muscle as a structural versus metabolic organ. Copyright: Elsevier Ltd. All rights are reserved.
Marcelo Freire #drInflammation retweeted
Get ready for our Fall 2024 Symposium—it’s less than a week away! It’s an excellent opportunity to learn about innovative studies our scientists are doing on #LongCovid #MECFS and #Lyme+.
polybio.org/fall-2024-sympos…
🎃Happy Halloween 🎃 From #JackSparrow. To me #Halloween is a day of fun, fantasy and creativity. Much love from the Pirates of the Caribbean 🏴☠️🎈🖤
