Head Serology and Immunology | Fondazione Biotecnopolo di Siena | Immunology | Monoclonal Antibodies | Vaccinology | Infectious Diseases 🇮🇹
Siena, Toscana
Joined December 2020
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I am delighted to share our last work on the in vitro evolution of a SARS-CoV-2 variant able to escape from a COVID-19 neutralizing plasma. @FondazioneTLS @VisMederi @AreaSciencePark @RommieAmaro Lab @McLellan_Lab
biorxiv.org/content/10.1101/…
Emanuele Andreano retweeted
As part of our 2025 “Rising Stars in #Vaccinology and #Immunity to #Microbes” seminar series, we spoke with Dr. Emanuele Andreano @e_andreano who uses #immunology, #structural_biology and #artificial_intelligence to develop antiviral countermeasures. cvimp.podbean.com/e/episode-…
Our new work on monoclonal antibodies to fight #gonorrhea just got out on @ScienceTM!
We are unleashing the full power of antibodies to accelerate vaccine development and new solutions to #AMR
Check the full paper out 👇
science.org/doi/abs/10.1126/…
Why do #mengingococcus vaccines partially protect against #gonorrhea?
Researchers identify antigens responsible for cross-protection and identify cross-reactive antibodies that can shield mice from gonococcus infection. @e_andreano @FondazioneTLS scim.ag/3SNMwYX
Emanuele Andreano retweeted
Antigenic sin and multiple breakthrough infections drive converging evolution of COVID-19 neutralizing responses dlvr.it/TCTcqz
Over the last 4 years our immune system kept evolving to fight SARS-CoV-2. In our last work, published on @CellReports, we longitudinally analyzed different cohorts to understand the evolution of the antibody response to SARS-CoV-2.
Here the full paper: cell.com/cell-reports/fullte…
Big thanks to the whole #MADLab at @FondazioneTLS and our incredible collaborators for the amazing effort @Virus_Immunity @NJTemperton #PietMaes #EtienneSimonLoriere @institutpasteur #UniversityofKent @unisiena #KULeuven
Emanuele Andreano retweeted
Antigenic sin and multiple breakthrough infections drive converging evolution
of COVID-19 neutralizing responses
sciencedirect.com/science/ar…
We interrogated our panel of almost 900 neutralizing human monoclonal antibodies to understand how JN.1 was able to evade the antibody response and become the main SARS-CoV-2 variant worldwide.
Check the full paper out published in Science Immunology: science.org/doi/10.1126/scii…
Emanuele Andreano retweeted
SARS-CoV-2 JN.1 variant L455S sequence abolishes the neutralizing antibody response of the publicly shared IGHV3-53/3-66, contributing to its global spread @SciImmunology @e_andreano Rappuoli
science.org/doi/10.1126/scii…
Emanuele Andreano retweeted
B cell maturation restored ancestral germlines to control Omicron BA.2.86 biorxiv.org/cgi/content/shor… #biorxiv_immuno
How the unceasing interplay between B cell response and SARS-CoV-2 pushed their continuous evolution? To answer this question we interrogated a panel of almost 1,000 neutralizing human monoclonal antibodies built over the last three years. Check it out: biorxiv.org/content/10.1101/…
A big thanks goes to all the people involved in this study #MADlab @FondazioneTLS @unisiena #UniversityofKent @KULeuven @institutpasteur @NJTemperton @Virus_Immunity
Emanuele Andreano retweeted
B cell maturation restored ancestral germlines to control Omicron BA.2.86 | bioRxiv fantastic collaboration with Monoclonal Antibody Discovery (MAD) lab, @FondazioneTLS Siena, Italy 🇮🇹 biorxiv.org/content/10.1101/…
Emanuele Andreano retweeted
... and this 'impossible review' on the future of cell & molecular biology marks the Amaro Lab's 200th paper
🍾🤓💜
So grateful & proud of this wonderful group, all members, past & present, helping make these impossible (nerd) dreams come true! 🥰❤️
We are standing on the cusp of a new era of biology, where the integration of multimodal structural datasets with multiscale physics-based simulation will enable the development of visible, virtual cells.
My dream for #COVIDisAirborne @kprather88 & the molecular basis of life 😍❤️🤓
doi.org/10.1016/j.cell.2024.…
Emanuele Andreano retweeted
We are standing on the cusp of a new era of biology, where the integration of multimodal structural datasets with multiscale physics-based simulation will enable the development of visible, virtual cells.
My dream for #COVIDisAirborne @kprather88 & the molecular basis of life 😍❤️🤓
doi.org/10.1016/j.cell.2024.…
Emanuele Andreano retweeted
Another example of #SARSCoV2 infected cells forming syncytia.
Label-free holotomography and AI-based image analysis
#Nanolive microscope
biorxiv.org/content/10.110
Emanuele Andreano retweeted
#AMR is a silent pandemic and new tools are needed to treat and prevent bacterial infection.
In our latest work, we have identified human monoclonal antibodies able to kill Gonococcus, a bacterium resistant to almost all class of antibiotics.
Check it out: biorxiv.org/content/10.1101/…
Emanuele Andreano retweeted
Human monoclonal antibodies reveal subdominant gonococcal and meningococcal cross-protective antigens biorxiv.org/cgi/content/shor… #biorxiv_immuno
#AMR is a silent pandemic and new tools are needed to treat and prevent bacterial infection.
In our latest work, we have identified human monoclonal antibodies able to kill Gonococcus, a bacterium resistant to almost all class of antibiotics.
Check it out: biorxiv.org/content/10.1101/…
Emanuele Andreano retweeted
Congratulations to Dr. Emmanuele Andreano @e_andreano from @FondazioneTLS for being chosen as an IUIS Rising Star to be honored at #IUIS2023.
This prestigious award is given to 15 of the most promising early investigators. Learn more at iuis2023.org.
