MD Neurosurgeon | PhD Pharmacology. Developer. Fooled by randomness. Back on twitter because of A.I. If you suspect I'm wrong, see my pinned tweet
Helsinki, Finland
Joined December 2008
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Esa-Pekka Pälvimäki retweeted
Earlier this week Tristan published his top YouTube channels:
thume.ca/2026/11/01/youtube-…
Which looked excellent so clearly I had to turn it into TristanTube:
karpathy.ai/tristan-tube/
47K super nerdy videos +TV mode for laid back watching. (One-shotted with Claude Code in 3 minutes)
Weekend hack: HackerTube. I was annoyed with YouTube's recommendations so I had Claude filter down 43M comments over 20 years of HN to 6,454 videos that keep being recommended. *Significantly* better viewing experience, ~2 hours with Opus 5.5:
hackertube.org/
- Excellent recs without any logins (state is kept in local browser session)
- Thumbnail is a representative frame from middle of the video instead of the super duper A/B test hyper-optimized user uploads
- Underlying data from the comment analysis as one zip file, point your Claude at it and ask for your own version
- HackerTube Longs ✊
A bit more on the process:
I use Claude Code (desktop app for Mac), Opus 5.5 on Medium effort as my default. I only talk to Claude and have it do everything, the only "manual work" I helped with in tandem was in the browser (reminiscent of MenuGen): 1) I had to create some kind of API key from Google Cloud UI to query YouTube for video metadata, 2) I booted up a VPS box for serving and 3) I bought the domain name. Once the box was up I gave Claude the IP and told it update, secure, harden, deploy and optimize the code, and it did the whole thing.
Many awesome projects that would have normally taken weeks/months even can now be few-shotted for breakfast. What else are we not thinking of.
Esa-Pekka Pälvimäki retweeted
Let me be blunt. Those who are afraid of AI feel deep down that they are impostors & have no edge. If you have a 1) clear mind, 2) a deep, not just cosmetic, undertanding of your specialty, 3) and/or are original enough to reinvent yourself when needed, AI will be your friend.
Not always easy to find the right setup. This seems to work so thought i'd share it, though it'll probably be stale in a week
708 PRs merged in Oct
Stack: Claude Code ultra + Codex pro subscriptions (1 each). Workers GLM-5.3 Flash xhigh → Terra 6.1 xhigh → Sol 6.1 high → Opus 5.5 medium or Sol 6.1 xhigh orchestrator, in ultracode mode. Grok bot for babysitting PRs and mobile orchestration.
Each PR: one cross-model review, GLM5.3 xhigh security review. Agents loop testing UI in browser/iOS simulator/phone rig. SHA-guarded auto-merge. Linear for issue tracking, though this is changing
Challenges: Disk space, cloud backup reliability, unnecessary hardcoded human gates in harnesses, costs creep up, complexity increases (hardware, security, management of scaling)
credit where due i'm using @theo 's sol-loop, full-send and full-stop and a modified grill-me from @mattpocockuk in addition to a number of custom skills. haven't updated my skills repo in a while but will do if someone is interested
Surgical resource management is an obvious domain for the deployment of agentic workflows and autonomous systems
Anthropic's IPO filing gives the Seven Founders, "distinctly equipped to be stewards of their mission", absolute power over the company. What could possibly go wrong?
Added @theo's oil to the machine:
- sol-loop
- full-send
- full-stop
Really sped things up 🚀
Turns out the answer is 42 after all
Jacob Tsimerman, who won the Fields Medal this year, thinks mathematics will soon rest on proofs no one understands. He says it’s already true of many of his own theorems, which build on accepted results whose proofs he doesn’t know.
Full episode: youtu.be/6uIJdXmB4vE
If you've got a laptop, an internet connection, and a hundred dollars a month, you can change the world
EU must rewrite the AI act completely and put all effort and funding into building its own foundational model. Otherwise, permanent irrelevance.
A fine litmus test on whether to mute someone on Twitter: if they get excited about the latest UFO stuff, there’s no reason to read their tweets on any other topic either. The prevalence of gullibility is staggering.
As long as the only piece of news you’re interested in when you wake up in the morning is the weather forecast, you’re doing ok.
Sairaalalääkärin työn henkistä ja fyysistä kuormittavuutta on vaikea ymmärtää ulkopuolelta.
hs.fi/mielipide/art-20000097…
