Certified Medical Illustrator | Associate Prof JHUSOM Entrepreneur, Science Story-teller; all words = mine, https://xitter.cf/t.co/4A1J1G0x0N
Baltimore, MD
Joined January 2011
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Jennifer E. Fairman, CMI, FAMI retweeted
See you on bluesky bsky.app/profile/fairmanstud…
We love our weird jobs! Great interview with fellow medical illustrator @Vin_the_human Vinald Francis on NPR: marketplace.org/2024/12/06/w… #weirdjob #medicalIllustrator
The damage from Hurricane Helene is heartbreaking. A good friend’s local shop has been destroyed, leaving workers without jobs. Please consider donating or sharing to help rebuild. Every bit counts. gofund.me/2eeb351d
I just backed Periodical and Annual Cicada Enamel Pins on @Kickstarter kickstarter.com/projects/car…
So excited to join The Generative AI Growth Mindset's course. Looking for a few friends to join me! maven.com/s/cb4b14cf16
Jennifer E. Fairman, CMI, FAMI retweeted
Checkout our new @MolecularOncLab website!
anagnostoulab.org/
We are looking for new wet lab members to join our multi-omics and liquid biopsy efforts (research tech and post-doc level -the latter for folks with a PhD in cancer biology-), contact us if there is interest!
ALT https://anagnostoulab.org/job-opportunities/
Another great collaboration and the featured cover with @Rock1MD Reyhan Westbrook, Mariann Gabrawy, @JeremyWalstonMD et. al. #kynurenine #NAD #frailty #geriatricmedicine onlinelibrary.wiley.com/doi/…
Jennifer E. Fairman, CMI, FAMI retweeted
#OpenAccess
Dual treatment with #kynurenine pathway inhibitors and #NAD+ precursors synergistically extends #life span in Drosophila 🪰🌟🔬
Applause to @ Mariann M. Gabrawy @ Reyhan Westbrook @JeremyWalstonMD @Rock1MD et al. 👏
onlinelibrary.wiley.com/doi/…
Exciting news of the week - just received my print copies of my latest journal cover! For Diabetes (journal for the ADA) Dax Fu, et. al.
@JohnsHopkins
@JhuMedart
#molecularvisualization #sciart diabetesjournals.org/diabete…
Jung’s Five Pillars of a Good Life - The Atlantic. I just love this! apple.news/AL_gcMHalTzWqPGpY…
Jennifer E. Fairman, CMI, FAMI retweeted
My pick for "the" mobile DNA paper of 2023 is actually two studies published back-to-back @Nature reporting the long-sought structure of L1 ORF2p _and_ fundamental insights into the mechanism by which L1 jumps. Amazing work. 1/n
nature.com/articles/s41586-0…
nature.com/articles/s41586-0…
Jennifer E. Fairman, CMI, FAMI retweeted
youtube.com/watch?v=amryk13y…
Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”.
aacrjournals.org/cancerdisco…
Jennifer E. Fairman, CMI, FAMI retweeted
Researchers from @MGHPathology and colleagues discover that structural analysis and inhibition of human LINE-1 ORF2 protein reveals novel adaptations and functions, in a @nature study. doi.org/10.1038/s41586-023-0…
Totally excited to see this! Go, Marty go!
Excited for the poster session at #SU2CScienceSummit and to share our work on the LINE-1 transposon and its role in cancer diagnostics and mechanisms.
Jennifer E. Fairman, CMI, FAMI retweeted
Link to the paper 👇nature.com/articles/s41586-0…
Jennifer E. Fairman, CMI, FAMI retweeted
Did you know that a significant portion of our genetic code, once dismissed as “junk DNA,” might hold a key to understanding diseases?
Scientists have uncovered what could be a game-changer in our understanding of health and disease:
massgeneral.org/news/researc…
Jennifer E. Fairman, CMI, FAMI retweeted
Using single particle cryo-EM, we determined three structures in different functional states. Apo ORF2p is in an active “thumb up” state; in contrast, apo viral RTs adopt an inactive “thumb down” state. This may explain ‘cis preference’: L1’s penchant for binding its own RNA
Jennifer E. Fairman, CMI, FAMI retweeted
We purified ORF2p ‘core’ and determined of a 2.1 angstrom crystal structure, facilitating discovery of two novel domains we name the ‘tower’ and ‘wrist’. These flank the fingers-palm-thumb domains of reverse transcriptase (RT), which grip the nucleic acid like a “right hand”
Jennifer E. Fairman, CMI, FAMI retweeted
L1 inserts a new, mutagenic copy of itself into the genome via ‘target primed reverse transcription’. Other outcomes contribute to pathology: failed insertions damage DNA, and we discovered here that aberrant cytosolic reverse transcription generates inflammatory RNA:DNA hybrids.
