Interested in repetitive elements, single-cell omics, multiple sclerosis and developmental biology
Stockholm
Joined April 2019
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Happy to see this out!
Here we suggest a transcriptional antagonism between ERVs and LINE-1s during the minor wave of the murine ZGA.
frontiersin.org/articles/10.…
@remosanges @SGustincich
Federico Ansaloni retweeted
Excited to share a new call for papers from Genome Research on somatic mosaicism. If you're working on something exciting in this area, consider submitting your work! The deadline is September 15, 2025. Looking forward to seeing your great science featured there.
The magic world of R....
The informal poll results are in, & as I feared, most people are running ANOVAs in #R with functions that can give highly misleading (or flat out wrong) results. Follow along to see why using anova() and aov() is usually inadvisable & why you should be using car::Anova() 🧵
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Federico Ansaloni retweeted
What is the origin of our body? Our paper @CellCellPress shows that when a human embryo is one day old and comprises just two cells, only one cell will create most of the fetus in addition to placenta, while the other cell will create placenta.
cell.com/cell/fulltext/S0092…
Federico Ansaloni retweeted
Warmly recommend to candidates interested in repeats, retrotransposons etc to consider this PhD position. Remo also collaborating with the Fantom.
SISSA works in English. Trieste is a beautiful city and not so expensive.
PhD positions available at SISSA in picturesque Trieste! A position available in my lab for a project in functional genomics – DM me for details. Only 10 days left... bit.ly/3JfaTtN #PhD #Research #Genomics #Transposons #SISSA #Trieste
Federico Ansaloni retweeted
Extremely happy to see this out!
Here we suggested that male mice can have a disadvantage relative to females in mastering difficult, appetitively-motivated learning tasks, likely due to sex differences in value-based decision-making!
frontiersin.org/articles/10.…
Federico Ansaloni retweeted
Disturbing visual similarities aside, which is worse? A laughably flawed AI anatomical hallucination that nobody took seriously, or a massive NIH project misusing UMAP hallucinations that wildly exaggerate genetic differences between races?
Everyone going apoplectic about someone publishing Midjourney hallucinations in a @frontiersin paper, but they're totally fine with people publishing T-SNE hallucinations in @nature.
Extremely happy to have contributed to this!
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Federico Ansaloni retweeted
Excited to announce this symposium that I organized with two amazing co-organizors Amanda Sferruzzi-Perri and Susana Chuva de Sousa Lopes. A great line of speakers and it is free registration thanks to StratRegen KI initiative by @ChristianGoritz @fredrik_lanner
Federico Ansaloni retweeted
PSA, since I've now seen problems arising from this: As of Sept 2023, GATK no longer makes missing genotypes explicit in VCFs (i.e. "./." as in the VCF spec). Missing genotypes are instead coded as "0/0" with a DP=0 format field. See attached for examples.
Interested in simultaneously profiling chromatin accessibility and two histone marks at single-cell resolution?
The single-cell nanoCUT&Tag protocol + computational workflow for data analysis is now out!
nature.com/articles/s41596-0…
@marekbartosovic @GoCasteloBranco
Federico Ansaloni retweeted
"Herpesviruses mimic zygotic genome activation to promote viral replication" 😯
researchsquare.com/article/r…
Federico Ansaloni retweeted
A single-cell transposable element atlas of human cell identity biorxiv.org/cgi/content/shor… #biorxiv_genomic
Federico Ansaloni retweeted
Did @10xGenomics just make newer versions of Cell Ranger open source? github.com/10XGenomics/cellr… (cc @sjackman, @luizirber). This is a huge win for open, transparent, and reproducible science if it’s the case!
Federico Ansaloni retweeted
Pleased to see the principles described in “Internal Ribosome Entry Site sequences act as Effector Domain in linear and circular antisense long non-coding SINEUP RNA” biorxiv.org/content/10.1101/… are independently validated in nature.com/articles/s41467-0… SINEUP technology works worldwide!
Federico Ansaloni retweeted
💥Excited to unleash ENCOTE: Encyclopedia of Transposable Elements with cis-regulatory activity in the human genome!
Collab w @twang5 for #ENCODE led by🔥trio Alan Du, Jason Chobirko & @XiaoyuZhuo
TEs = 25% of all cCREs = 200,000+ elements!!
Deep dive! 1/n biorxiv.org/content/10.1101/…
Finally out! Happy to have contributed to this:
LINE-1 regulates cortical development by acting as long non-coding RNAs
nature.com/articles/s41467-0…
Federico Ansaloni retweeted
We are mourning the death of Prof. em. John Nicholls, who passed away on July 13, 2023. We bid farewell to a pioneer in neurobiological research and a dedicated and passionate scientist who played an important role in shaping the @biozentrum. ow.ly/x4Ii50PgS4m
Federico Ansaloni retweeted
Do you know that protein-RNA interactions can be predicted from single cell transcriptomics? Here is a new exciting story by Johnny, Alex and Alessio!
biorxiv.org/cgi/content/shor…
This would make sense with previous evidence showing how LINE-1 mRNAs are required to switch-off the 2C transcriptional program allowing embryos to develop beyond the 2-cell stage: i.e., antagonist pathways are activated/regulated from spatially separated genomic compartments
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