Luke Fehily (@fehelium) header
Luke Fehily (@fehelium) profile picture

Producer, Memo to File: https://teapaw.org/t.co/hQAqLhSWCB

Joined August 2024
Photo by Luke Fehily (@fehelium)Photo by Luke Fehily (@fehelium)Photo by Luke Fehily (@fehelium)Photo by Luke Fehily (@fehelium)Photo by Luke Fehily (@fehelium)Photo by Luke Fehily (@fehelium)Photo by Luke Fehily (@fehelium)Photo by Luke Fehily (@fehelium)Photo by Luke Fehily (@fehelium)Photo by Luke Fehily (@fehelium)
Luke Fehily retweeted
Time to bring back this Tyler Cowen banger
From today, new EU rules apply to all packaging placed on the EU market. They cover design, composition, reuse and recycling — with obligations phased in through to 2030 and beyond. What changes, and when ⬇️ consilium.europa.eu/en/polic…
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New from me: Young people in Britain are some of the most well-educated in the rich world, but economic stagnation means that breeds not growth but frustration. In fact, US workers who are functionally illiterate now earn roughly the same per hour as the average British worker.
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Luke Fehily retweeted
Hot off the presses! How should policymakers think about choosing between different innovation funding mechanisms? A lot comes down to: 1) How clearly can you articulate the problem that needs to be solved? 2) How concretely can you specify the solution that would solve the problem? 3) How obvious is the team that is best positioned to make progress on this problem? Full framework here: nber.org/papers/w35549
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Luke Fehily retweeted
There are some exceptionally good ideas here for reforming and accelerating science. Some of my favorite proposals: Apply the scientific method to science funding (track applications, reviewers, funding decisions, and outcomes, then experimentally test which grantmaking methods actually produce breakthrough work) Build a portfolio of funding mechanisms instead of treating peer review as universal (fast grants, long-horizon funding, golden tickets, regranting, prizes, and advance market commitments) Create organizations between the university lab and the national lab (Focused Research Organizations and X-Labs built for time-bounded, engineering-intensive scientific missions) Turn federal scientific infrastructure into a true research commons (open national-lab facilities, compute, cleanrooms, instruments, testbeds, and technical expertise to startups and outside researchers) Use precompetitive consortia and grand challenges for shared bottlenecks (Human Genome Project-style efforts to build datasets, standards, tools, and infrastructure no company would build alone) Elevate technicians, makers, and tacit technical knowledge (fund apprenticeships, technician fellowships, machine-shop training, practitioner residencies, and nonacademic pathways into scientific research) Treat AI-for-science as a full stack, including verification (models, curated data, negative results, compute, interoperable instruments, robotic labs, replication, and machine-auditable evidence) Reform publication around research objects, not papers (publishing datasets, code, protocols, null results, methodological notes, and evolving “dynamic papers") Disagree with some of it -- mainly the overtly political bits -- but overall an excellent blueprint!
In response to @POTUS's call for a revival of America's scientific enterprise, today I’m releasing Science: A New Golden Age. This report is a blueprint for renewing American scientific leadership for the 21st century.
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Luke Fehily retweeted
Surreal endnotes section to have in an official government report – at Mount Rainier, MD
In response to @POTUS's call for a revival of America's scientific enterprise, today I’m releasing Science: A New Golden Age. This report is a blueprint for renewing American scientific leadership for the 21st century.
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Luke Fehily retweeted
A plausible and frightening vision of Europe's near future, ending in economic collapse and vassal status under the US or China. Enjoyed reading it, although I feel a little depressed now. europe2031.ai/
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Luke Fehily retweeted
Episode 5 of Memo to File is out now! Retired Garda Detective Chief Superintendent Pat Byrne discusses the Criminal Assets Bureau from his experience as CAB's first Detective Inspector and later its Chief Bureau Officer. linktr.ee/memotofilepodcast
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Luke Fehily retweeted
This has quietly been a miracle month in medicine. In the last 5 weeks we’ve got news on: - retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels - RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life - small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol - Mayo’s AI-assisted radiology showing vastly improved cancer detection - this new therapy for metastatic solid tumors This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.
This is actually insane. 97% of people taking the standard of care for metastatic solid tumor got worse by seven years. But with lorlatinib, that number was only 45% in the same time! This is an ENORMOUS jump in the quality of cancer care.
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Luke Fehily retweeted
New blog post: The third wave of American philanthropy Hundreds of billions of dollars in new philanthropic capital will soon become liquid. The OpenAI Foundation holds 26% of OpenAI, worth about $220B at today’s valuation. Anthropic’s seven co-founders have pledged to give away 80% of their wealth and have instituted the most aggressive donor matching program for employees in tech history. How much does this all add up to? And how meaningful is that in the context of philanthropy today? I was doing some simple napkin math to wrap my head around the scale of what’s coming, and radicalized myself in the process. I had dramatically underappreciated the scale of the philanthropic capital that’s about to become available and the corresponding gap in talent and organizations that will be needed to make the most of it. This piece aims to directionally sketch the scale of what’s coming, the gap in operational capacity needed to absorb it, and what we can do to fill it. (Link to full post in reply)
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Brian Chesky shares why the saddest day of his life happened the day after Airbnb went public at $100B: "We go public, we have a hundred billion dollar valuation. It's one of the best days of my life. The next day, I go on a Zoom meeting, and it was like it never happened." "It became like the saddest day of my life. Because I realized, I got all this adulation, and I don't feel any different." "Adulation is like a cup with a hole at the bottom. You keep filling it in, thinking it's love, except it just keeps coming out the bottom." "That made me reevaluate what I'm doing this for. I want to do things for pure intrinsic reasons. Do the work like you used to do, like when you were a kid. It was light. Just make stuff. Make it for yourself." "So many entrepreneurs focus on what they want to be. "I want to be a giant tech founder. I want to run a billion-dollar company." Instead of focusing on, "What do I want to make." There's no way to fail if you're making what you love."
My guest today is Brian Chesky (@bchesky), founder and CEO of Airbnb and one of the great consumer founders of the last 20 years. Paul Graham coined "founder mode" based on Brian's experience running Airbnb. This conversation is about what comes after it, what he calls AI founder mode, and how it will force founders to focus even more on the details. We talk about his eleven-star exercise for finding product market fit, why your first hire should be a recruiter, and why Airbnb's $100B IPO became one of the saddest days of his life. Brian still comes across like the 17 year-old at the Rhode Island School of Design (RISD) who picked to study industrial design. His heroes are all artists. Da Vinci, Van Gogh, Walt Disney, and Steve Jobs, all of whom were working the week they died because they loved what they did. Rick Rubin taught him that an artist is only an artist when they make things for themselves. Now Brian believes AI is the opportunity for all of us to do the same. Enjoy! Timestamps: 1:00 Studying Industrial Design 11:33 AI Founder Mode 17:02 Lack of Consumer AI Companies 22:10 Small Teams and Focused Problems 30:52 The Evolution from Founder to CEO 38:13 The 11-Star Experience 41:07 AI as a Canvas for Creativity 48:17 Detaching from Success 53:12 Founder-Led Moats 58:34 The Next Chapter of Airbnb 1:03:08 What Endures in the Age of AI 1:06:43 Lessons from Bodybuilding 1:10:20 The CEO's No. 1 Job 1:17:01 Activating Talent 1:20:39 The Kindest Thing
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Luke Fehily retweeted
The Memo to File podcast launches today! @fehelium and I have been working on this project to explore Irish public projects with those central to their delivery. On Ep. 1, Frank Allen discusses Luas light rail in Dublin. Memo to File drops Thursdays and is available below.
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Launching the Memo to File podcast!! I've learned so much speaking to the people that made Ireland better about doing good work, lessons learned, and the institutional memory often lost over time. On Episode 1, Frank Allen discusses building Luas. Link in bio!
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Bernd and Hilla Becher Blast Furnaces (sequence) c. 1965
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Luke Fehily retweeted
Just remembered the story about a computer scientist who had his bike stolen and tried to explain binary search to a cop
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It’s not just new, it’s newspeak
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Luke Fehily retweeted
One noteworthy point (among many!) is that when you read this list of topics: 1. They are pretty clearly important for the future 2. They are absent from priority areas for most western research support which generally sounds like "quantum, AI, health, climate, etc."
New essay: China and the Future of Science
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Luke Fehily retweeted
Born in Liscannor, Ireland in 1840, submarine inventor John Phillip Holland’s designs were adopted by the U.S. Navy in 1900. Happy St. Patrick’s Day!
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Luke Fehily retweeted
By far my biggest advice to anyone trying to adopt AI properly: 1. Pay a little bit of money to Anthropic 2. Download Claude Code 3. Open Claude Code 4. Press 'Shift-Tab' until it says 'plan mode on' 5. Open Voice Memo on your iPhone. Just talk about all the things you want to accomplish. When you think you are done, just keep talking. Make sure it is at least 10 minutes, hopefully longer 6. Send this Voice Memo to your computer 7. Download MacWhisper and use it to transcribe this voice memo. Trust me, you will want MacWhisper and will use it later a lot 8. Type into Claude Code: "I have never used you before but I talked about some things. I will paste those things in below. Please read the things and ask me any questions you need to in order to help me figure out how to use you to be awesome. Ask me lots of questions until I tell you I am done" 9. Then paste in the transcript 10. Then press enter Then just let Claude take the wheel, and them please send me a DM if this works. Also, if this just sounds crazy, just literally take this entire message and paste it into whatever AI you are using and say 'some weird person told me to paste this into you, I want to use it, but I don't know how. What should I do?' I am just trying to help you get started. Curiosity and persistence are the most important things.
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We’re thrilled to open-source LabClaw — the Skill Operating Layer for LabOS by Stanford-Princeton Team One command turns any OpenClaw agent into a full AI Co-Scientist. Demo: labclaw-ai.github.io Dragon Shrimp Army reporting for duty 🦞🔬 #AIforScience #OpenClaw
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Luke Fehily retweeted
Three days ago I left autoresearch tuning nanochat for ~2 days on depth=12 model. It found ~20 changes that improved the validation loss. I tested these changes yesterday and all of them were additive and transferred to larger (depth=24) models. Stacking up all of these changes, today I measured that the leaderboard's "Time to GPT-2" drops from 2.02 hours to 1.80 hours (~11% improvement), this will be the new leaderboard entry. So yes, these are real improvements and they make an actual difference. I am mildly surprised that my very first naive attempt already worked this well on top of what I thought was already a fairly manually well-tuned project. This is a first for me because I am very used to doing the iterative optimization of neural network training manually. You come up with ideas, you implement them, you check if they work (better validation loss), you come up with new ideas based on that, you read some papers for inspiration, etc etc. This is the bread and butter of what I do daily for 2 decades. Seeing the agent do this entire workflow end-to-end and all by itself as it worked through approx. 700 changes autonomously is wild. It really looked at the sequence of results of experiments and used that to plan the next ones. It's not novel, ground-breaking "research" (yet), but all the adjustments are "real", I didn't find them manually previously, and they stack up and actually improved nanochat. Among the bigger things e.g.: - It noticed an oversight that my parameterless QKnorm didn't have a scaler multiplier attached, so my attention was too diffuse. The agent found multipliers to sharpen it, pointing to future work. - It found that the Value Embeddings really like regularization and I wasn't applying any (oops). - It found that my banded attention was too conservative (i forgot to tune it). - It found that AdamW betas were all messed up. - It tuned the weight decay schedule. - It tuned the network initialization. This is on top of all the tuning I've already done over a good amount of time. The exact commit is here, from this "round 1" of autoresearch. I am going to kick off "round 2", and in parallel I am looking at how multiple agents can collaborate to unlock parallelism. github.com/karpathy/nanochat… All LLM frontier labs will do this. It's the final boss battle. It's a lot more complex at scale of course - you don't just have a single train. py file to tune. But doing it is "just engineering" and it's going to work. You spin up a swarm of agents, you have them collaborate to tune smaller models, you promote the most promising ideas to increasingly larger scales, and humans (optionally) contribute on the edges. And more generally, *any* metric you care about that is reasonably efficient to evaluate (or that has more efficient proxy metrics such as training a smaller network) can be autoresearched by an agent swarm. It's worth thinking about whether your problem falls into this bucket too.
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