Discovering the mysteries of life. One algorithm at a time.
Ann Arbor, MI
Joined November 2009
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If you could read the DNA of half a million people, would you do it and why? Would it work? What would you learn?
To answer this and several related questions, let me walk you through the work my @RegeneronDNA colleagues just published in Nature. 1/24
nature.com/articles/s41586-0…
Sometimes you gotta love @Microsoft, sometimes they are comically bureaucratic/evil.
I had to reinstall @Windows on my son’s PC due to drive failure. This downgraded Windows Pro to Windows Home.
After 5 hours with support (where they re-installed 3x more!!), they told me that reinstalling required accepting downgrade or paying the $100 upgrade fee again! After all, it’s a one time fee!
And they are absolutely adamant that’s reasonable— despite the fact I had the receipts for my Windows purchase and that the PC hasn’t changed!
But, hey, they were using @Copilot to check their answers.
Maybe something for @FTC or @NewYorkStateAG to look at.
If you are curious why I need Windows Pro on a child’s PC, it’s because Windows screen time is super easy to hack otherwise.
So, per @Microsoft … allow your kids unlimited time on @Windows or pay us $100 periodically.
19th century robber barons in the digital age.
Goncalo Abecasis retweeted
This week's news podcast features Doug Weir (@ceobs_org) on the impact of conflict on health and the environment; @gabecasis (@Regeneron) on gene variants and smoking; Viktoria Eleftheriadou (BAD) on vitiligo; and Daniel Harris (@Penn) on Neanderthals
thenakedscientists.com/podca…
Thrilled at this win-win partnership!
1/4
investor.regeneron.com/news-…
Equally important, continuing the personal genetics business means that the challenge and mission of communicating information about health and disease to customers will continue. There’s few things more special than helping people understand themselves and the world. 3/4
Human genetics advancing at speed because technology, sample size, great phenotypes, smart people. #ASHG24
If interested in NY area + models + toolkits for health records and phenotypic data to be organized across millions of people… DM me.
Great coding, clear thinking.
2/3
Okay, okay … even though #ASHG was critical in meeting great friends and landing the best jobs I ever had … I am not just #hiring.
If you are trying to sequence 100,000s of well characterized samples, we @RegeneronDNA would like to help.
DM me or stop by #ASHG24 booth.
3/3
Very touching “Stand Up 2 Cancer” moment in the Yankees - Dodgers World Series.
As geneticists and scientists, we should stand up 2 cancer too. It’s incredible what targeted therapies have done, and we are only skimming the surface of what they can do.
Watch this space.
Goncalo Abecasis retweeted
Not sure how you can look at this data, ostensibly be interested in either meritocracy or equality, and want to move away from standardized tests. It's the subjective measures that are most slanted in favor of the rich kids.
nytimes.com/interactive/2023…
An actual civil war in the world’s biggest nuclear state.
I pray for the people of Russia, Ukraine and all of us.
wsj.com/livecoverage/russia-…
@ewanbirney I am not worthy! It’s like comparing a nice coffee that the barista just prepared in your local coffee joint with the instant coffee you found on the counter and warmed in the microwave!
Goncalo Abecasis retweeted
A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]
Goncalo Abecasis retweeted
My personal gratitude to @J__Stock for his partnership on so much of our TOPMed #CHIP work. Josh has written TWO first author Nature papers and another forthcoming manuscript in @ScienceAdvances -- a singularly impressive PhD track record! nature.com/articles/s41586-0…
Goncalo Abecasis retweeted
🚨 Publication alert: largest to date multiancestry exome analysis of body fat distribution discovers INHBE mutations associated with favorable adiposity and PROTECTION from diabetes! 🚨
Out today in @NatureComms
👇🧵 key takeaways below…
nature.com/articles/s41467-0…
Goncalo Abecasis retweeted
Importantly CIDEB mutations show the largest protection of liver disease in obese people, also lower liver inflammation in bariatric surgery patients from @GeisingerRsrch: A very important finding because #obesity is THE #1 risk factor for #NASH.
