@hardsphere

Dreamer, pragmatist, believer that intelligent design will make better molecules and organisms than evolution. I/me. All views plagiarized, most unwittingly.

Joined September 2009
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146Media
Had deep neural networks been invented before Newton, physics would not have looked the same.
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Huafeng Xu retweeted
Ethan Kurzweil
@ethankurzMay 19
Drug discovery has always been a race against time. Fathom Therapeutics is trying to change the pace entirely — using physics + AI to design drugs fast enough to outrun disease. We joined their recent $47M Series A alongside @shv and are excited to support @hardsphere and team.
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Ironically, we now pin our hopes of transforming biology into a predictable, reproducible, and deterministic engineering discipline on neural networks, a technology inspired by biology and, rare among engineered systems, itself unpredictable and non-deterministic.
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Rich people are different. They chase what money cannot buy: they chase what only an excessive amount of money can buy.
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The discovery of a new medicine is a rare event. Can AI help turn the improbable into the likely? My (digressive) thoughts on how AI may impact drug discovery in a meandering post. Title inspired by Blade Runner. Style warped by sleep deprivation. medium.com/@huafeng/do-neura…

Do neural networks dream of drug molecules?

Do neural networks dream of drug molecules? To answer this question, we must first acknowledge the miracle of drug discovery itself, that drugs can work in the first place. You take a pill …

medium.com
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I just got recommended to the recruiter for a job I am hiring for. Flattered, twice.
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Did the pants-to-shirts sales ratio decrease with the rise of remote meetings?
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Suspicious?
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The most notable effect of AI on science will not be the solution of outstanding scientific problems but the shortening of author list in scientific publications. We might soon see single author papers describing complex scientific works that previously call for a team.
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Antonie van Leeuwenhoek’s microscope and Anton the computational microscope.
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I have used both, one much more than the other.
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I like a watermelon because “you can eat, drink, and wash your face all at the same time.” What is this monstrosity that takes away two thirds of the fun?
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Is this what people call a dream job?
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“With due respect” is invariably followed by words spoken without respect.
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I share my thoughts on the enabling elements that drive rapid technological advances: public attention, scientific foundation, talent pool and empowering infrastructure, focus on value creation, technology integration, and sufficient investment. tinyurl.com/5n8srpsc
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AI’s results feel adequate when I have no clear expectations—but often fall short when I do.
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Wenfeng Liang, who founded and led the DeepSeek team, is one of the over one hundred authors of the DeepSeek paper, but he is neither the first nor the last author, and there is no asterisk next to his name. That alone is a distinction.
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So much excitement but maybe it is still a stochastic parrot?
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So much excitement but maybe it is still a stochastic parrot?
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The watchful eyes on the wall.
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No computer game can match the thrill, mental focus, and purpose of structure-based drug design turbocharged with molecular simulations. But you have to wait for a couple of weeks before getting your game score.
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