@hon_lab

Assistant professor @ UT Southwestern, perturbing genomes to understand principles of cell state, development, and disease.

 Dallas, TX
honlab.org
Joined March 2017
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  • Following144
  • Followers416
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We are excited to share our work on genome-scale functional characterization of candidate cis-regulatory elements (cCREs) in iPSCs and during neuronal differentiation, funded by @ENCODE_NIH and @4DNucleome biorxiv.org/content/10.1101/… 1/11

Functional characterization of gene regulatory elements and neuropsychiatric disease-associated...

Genome-wide association studies (GWAS) have identified thousands of non-coding variants that contribute to psychiatric disease risks, likely by perturbing cis -regulatory elements (CREs). However,...

biorxiv.org
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Join us TOMORROW at 10:00 in F4.118 for grad student Daniel Armendariz's dissertation defense: "CHD-Associated Enhancers Shape Human Cardiomyocyte Lineage Commitment" @hon_lab @GDDgradprogUTSW
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We are #recruiting #MedicalInformatics #Faculty to fill a joint appointment with @CIC_UTSW. Focus - innovation of computational approaches to address pressing problems in disease prevention, recognition, and management, and/or public health. Apply today! tinyurl.com/4cztzus4
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Excited to share our work using scRNA-seq to investigate atopic dermatitis #TheOtherAD. Great collaboration with the Drechsler lab. 🐶jimmunol.org/content/209/7/1…
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kircherlab.github.io is recruiting 2 PostDocs (tinyurl.com/HLpostDoc. tinyurl.com/igvfHLpostDoc). Apply by Oct 10, 22. We are part of #IGVF, analyze reg. variant effects (MPRAs/CRISPR screens) and develop new comp. models & tools w/ @JShendure, @NadavAhituv, @malte_spielmann.
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Thanks, Sam. This study establishes proof-of-concept for a cardiomyopathy diagnostic algorithm using chromatin accessibility signatures at a sequencing depth achievable by benchtop instruments. Code : jlduan.github.io/cardiomyopa…

Accurate Classification of Cardiomyopathy Diagnosis by Chromatin Accessibility

This study establishes proof-of-concept for a cardiomyopathy diagnostic algorithm using chromatin accessibility signatures at a sequencing depth achievable by benchtop instruments.

jlduan.github.io
Sam BhattacharyyaPhD@SamBhattachary313 Sep 2022
Very excited to share my post- doctoral publication in ⁦@CircAHA⁩ co-first authored by an extremely talented #computationalbiologist jialeiduan. This was the product of after-work hours, cross country collaboration, and effective communication. ahajournals.org/doi/10.1161/…

Accurate Classification of Cardiomyopathy Diagnosis by Chromatin Accessibility | Circulation

ahajournals.org
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Very excited to share my post- doctoral publication in ⁦@CircAHA⁩ co-first authored by an extremely talented #computationalbiologist jialeiduan. This was the product of after-work hours, cross country collaboration, and effective communication. ahajournals.org/doi/10.1161/…

Accurate Classification of Cardiomyopathy Diagnosis by Chromatin Accessibility | Circulation

ahajournals.org
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utsouthwestern.edu/departmen… Apply today! #Bioinformatics #ComputationalBiology #Undergraduate #Prizes
Lyda Hill Department of Bioinformatics@LHBioinf_UTSW23 Aug 2022
Check out a #Research #Competition for #UnderGrads in #Bioinformatics & #ComputationalBiology that we're sponsoring with @UTSWcomps! utsouthwestern.edu/departmen… Spread the word and apply today!
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Bing Ren lab 20th anniversary - a fun and memorable event in sunny SD! Organizing this with @hon_lab, @hawkins_lab, Allen Wang, and Lauren Thomas is a great honor. We had many excellent talks, activities, and even a rainbow during dinner! Thank you all for joining us!
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We are excited to share our preprint on how “CHD-associated enhancers shape cardiomyocyte lineage commitment.” Awesome collaboration with Nik Munshi’s lab at UTSW. A tweetorial follows. (1/8) @GDDgradprogUTSW @CRSM_UTSW @DannyArmen biorxiv.org/content/10.1101/…

CHD-associated enhancers shape human cardiomyocyte lineage commitment

Enhancers orchestrate gene expression programs that drive multicellular development and lineage commitment. Thus, genetic variants at enhancers are thought to contribute to developmental diseases by...

biorxiv.org
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Finally, we generated genetic knockouts for two TBX5 enhancers. Enhancer deletion analysis mirrors that of CRISPRi, with knockout cells showing a marked reduction of mature CMs states. (7/8)
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In summary, we used single-cell screens to functionally characterize enhancers in a model of human development. How do enhancers contribute to cell fate specification and diseases of human development like CHD? We are excited to learn more in the IGVF Consortium. (8/8)
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Awesome way to end the year! Jeremiah Herbert delivered an incredibly clear and compelling thesis defense today. Very proud to be his mentor and extremely excited for his next big step! @UTSWGradSchool
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We are delighted to share the latest results from the lab as we explore complex engineering. A massive collaborative effort more than 2 years in the making. Progress was slowed by the pandemic, but we remained determined. Thanks to the lab for this huge accomplishment!
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We have a postdoc position available in the lab. Come join us to investigate how biomolecular condensates regulate gene activity in normal and disease cell states. Please RT. jobrxiv.org/job/ut-southwest…… #ScienceJobs #generegulation #biocondensates

Postdoc position to investigate nuclear condensates in gene control

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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