Postdoc at @idisbaib • Developing 3D BBB models • PhD w/ @XavierTrepat @ibecbarcelona & MSc w/ @ClaudioAFranco1 @IMMolecular.
Barcelona, Spain
Joined November 2012
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🎉 Our haptotaxis paper is now published! 🎉
The final version has some cool new data on gradient magnitudes, sawtooth patterns & more!
Check it out 👉 nature.com/articles/s41567-0…
New preprint from the lab! We studied how single cells migrate up, down and about fibronectin gradients. Experiments by @icfortunato , theory by David Bruckner. Collaboration with @EdouardHannezo and @RaimonSunyer @IBECBarcelona
biorxiv.org/content/10.1101/…
Isabela Corina Fortunato, PhD retweeted
A new review that is not to be missed! 🆕🙌
Dr. Shaochen Chen, Jacob Schimelman and their @UCSanDiego team summarizes the complexities involved in generating physiological #vasculature: bit.ly/4u6uNwU
They discuss progress across several core technology categories, including #organoid-based and microfluidic-based platforms to model the vasculature. 🩸
Isabela Corina Fortunato, PhD retweeted
Scientists show that the neuroprotective role of Trim47 in brain damage is achieved by preserving BBB function through interaction with ZO1 and by reducing brain microvascular endothelial inflammation through the suppression of NF-κB activation. 🧠
go.nature.com/4ugUv25
Isabela Corina Fortunato, PhD retweeted
A fired public-health official, a mosquito breeder, and a baby with a smile seen around the world
These are just a few of the remarkable people chosen for Nature's 10 2025 go.nature.com/3MANiZt
Isabela Corina Fortunato, PhD retweeted
❣️New in @JExpMed
Proud to have contributed to the work of Cornelia Halin’s lab @ETH_en
Single-cell & 3D imaging reveal unexpected diversity of human afferent lymphatic vessels including unique CD24⁺ valve LECs and key differences from mouse skin.
rupress.org/jem/article/223/…
Isabela Corina Fortunato, PhD retweeted
This is the best way to understand how ML models actually work!
Use Drawdata to draw a 2D dataset in Jupyter. Use it to actively pick data from the widget and update the model as the data is being drawn!
Fully interactive, real-time, and open-source!
Isabela Corina Fortunato, PhD retweeted
Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis.
elifesciences.org/articles/9…
Isabela Corina Fortunato, PhD retweeted
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out: epithelialmechanics.github.i…
Huge thanks to all thread-contributors and to you for following us!
Isabela Corina Fortunato, PhD retweeted
Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis.
elifesciences.org/articles/9…
Paper explained in podcast format 👇
open.spotify.com/show/26MvnX…
Big thanks to every co-author who made this possible, especially @DavidBrückner @EdouardHannezo for leading the modeling & @RaimonSunyer @XavierTrepat for the invaluable supervision.
Isabela Corina Fortunato, PhD retweeted
El día se ha completado con una foto de familia de la #RICORSICTUS con la subdirectora del @SaludISCIII Pilar Gayoso.
Investigadoras/es en #ictus trabajando de forma coordinada para conocer, prevenir y mejorar el tratamiento de esta enfermedad
Isabela Corina Fortunato, PhD retweeted
1️⃣For years, scientists have known that mechanical tension influences cell behavior. But in our recent study in @NatureMaterials we found that it is not just the amount of tension—it is the direction!
nature.com/articles/s41563-0…
Isabela Corina Fortunato, PhD retweeted
If you are interested in vascular malformations you may want check our new work published today @CD_AACR , where we discover a somatic genetic event causing vascular malformations in PTEN hamartoma tumour syndrome (PHTS) aacrjournals.org/cancerdisco…
Isabela Corina Fortunato, PhD retweeted
Stoked to present our latest, brilliantly led by Chris et al & Alejandro Torres-Sanchez. How tissues are patterned during development – we found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n biorxiv.org/content/10.1101/…
Isabela Corina Fortunato, PhD retweeted
Nature research paper: Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium
go.nature.com/4hjYsvz
Isabela Corina Fortunato, PhD retweeted
Interesting review on engineering biological curvatures
cell.com/trends/biotechnolog…
Isabela Corina Fortunato, PhD retweeted
Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
elifesciences.org/articles/1…
Isabela Corina Fortunato, PhD retweeted
Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway. #DevBio
elifesciences.org/articles/9…