#MSCA PhD fellow: working on structural biophysics of neurotransporters, @cloland_dk, University of Copenhagen @NeuroTransETN @ISBUC1
Joined September 2018
- Tweets137
- Following419
- Followers211
- Likes602
Thrilled to share that my PhD journey has come to an end! Huge thanks to my supervisor Claus @cloland_dk and the amazing Loland lab! Grateful to my assessors, Prof. Simon Newstead, Prof. Bjorn Pedersen, and Prof. Nanna MacAuley, for a great discussion during my examination! 🎓
@iris_kalen is now Dr Iris. An excellent PhD thesis was presented and defended with bravour. Thanks to the assessors @BrainH2O_Lab (chair), @inwardopen and @BjornPPedersen.
Congrats Marie!🥂🎉
@MarieGram is defending her PhD illustrating how her fluorescent cocaine analogues can show that they are protonated when binding to the dopamine transporter. Thanks to @DFF_raad for support.
Iris Kalenderoglou retweeted
We often think of an "equilibrium" as something standing still, like a scale in perfect balance.
But many equilibria are dynamic, like a flowing river which is never changing—yet never standing still.
These dynamic equilibria are nicely described by so-called "detailed balance"
Iris Kalenderoglou retweeted
Excited to share our latest research on how cholesterol influences the clustering and plasma membrane curvature biogenesis of the influenza M2 proton channel using coarse-grained MD simulations! 🦠🧬 Read the paper here: pubs.acs.org/doi/10.1021/acs…
Iris Kalenderoglou retweeted
YAY! Our paper showing insertion of the fluorescent non-canonical amino acid Anap into SERT is out. We directly measure binding of ions, inhibitors and substrates, and estimate on- and off-rates. Grateful to @novonordiskfond, @DFF_raad & @Carlsbergfondet.
rdcu.be/dYkKR
Iris Kalenderoglou retweeted
Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter | bioRxiv
biorxiv.org/content/10.1101/…
An exciting @NatureMedicine publication highlights the repurposing of vortioxetine, an approved and affordable antidepressant, for the treatment of #glioblastoma!
A single-cell ex vivo screening of repurposable drugs in #glioblastoma coupled with machine learning show that anti-tumour neuroactive drugs converge on the AP1-BTG pathway and identify the antidepressant vortioxetine as a potential therapeutic agent.
nature.com/articles/s41591-0…
Iris Kalenderoglou retweeted
Next level reconstitution: Combining the malate decarboxylation pathway with transporters (GltP, LacY) in liposomes, Miyer and Zaid generated stable proton and electrical potential gradients and accumulation of glutamate and lactose over periods of hours.nature.com/articles/s41467-0…
Our most recent research on Influenza A M2 proton channel!
Check out our latest research on how the #InfluenzaA M2 proton channel curves the surrounding membrane through cholesterol-induced self-clustering, a key step in early viral budding. The team: @iris_kalen @drannaduncan @mark_sansom @RobinCorey1 Official pub out soon!
Iris Kalenderoglou retweeted
Check out our latest research on how the #InfluenzaA M2 proton channel curves the surrounding membrane through cholesterol-induced self-clustering, a key step in early viral budding. The team: @iris_kalen @drannaduncan @mark_sansom @RobinCorey1 Official pub out soon!
The Role of Cholesterol in M2 Clustering and Viral Budding Explained biorxiv.org/cgi/content/shor… #biorxiv_biophys
Iris Kalenderoglou retweeted
Introducing ✨MAASTY✨ - a novel copolymer designed for isolated membrane proteins into native lipid nanodiscs for structural and functional studies.
Read our preprint here: biorxiv.org/content/10.1101/…
Get an overview tweet series from @HenrietteAutzen below 👇
🌟Exciting news!🌟 I’m thrilled to share our latest preprint, which marks a special milestone. This manuscript, authored by my brilliant PhD student @ciara_pugh is her first scientific paper with my group and presents the first high-resolution cryo-EM structure from my group!
Iris Kalenderoglou retweeted
The 10 biggest medical research papers from this week (🧵)
1. A high resolution structure of the dopamine transporter - key to Parkinson's, schizophrenia, and addiction
Here's what it looks like bound to cocaine, one of its ligands (in orange)
(Study: nature.com/articles/s41586-0…)
Iris Kalenderoglou retweeted
Here we go! Our structure of the human dopamine transporter in complex with cocaine has been published in Nature (nature.com/articles/s41586-0…). Commentary by @SitteHarald (nature.com/articles/d41586-0…). Thanks to @ShahsavarAzadeh and Pape for contributing. @neuroscience_dk, @UCPH_health
Iris Kalenderoglou retweeted
Unveiling a missing transport link in energy production. elifesciences.org/digests/94…
Iris Kalenderoglou retweeted
Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!
Iris Kalenderoglou retweeted
Come and find out how to micRo_manage BAT! Representing Mark Christian's lab at #SFEBES2023 conference. @NTUSciTech @ntu_research @NTUBIOSCIENCES @trentuni #ntu #Endocrinology #mirna #obesity #adipose – at Glasgow, Scotland
Iris Kalenderoglou retweeted
Biologists have produced a strain of yeast whose genome is more than 50% synthetic DNA go.nature.com/3Qtp2a3
Iris Kalenderoglou retweeted
First of its kind modality disrupting the interaction between SLC15A4 and TASL. Congratulations to the @gsf_lab @CeMM_News @rebsamenlab @leoheinz and the Yang lab for an exciting discovery with groundbreaking implications for autoimmune diseases! nature.com/articles/s41467-0…
