Neurologist, Epileptologist @Mayo Clinic, Rochester, MN. Tweets are my own.
Rochester, MN
Joined September 2009
- Tweets3K
- Following1.9K
- Followers1.3K
- Likes12.7K
Gamaleldin osman retweeted
Do preclinical seizure models predict success or failure in anti-seizure drug development? A retrospective analysis of 89 compounds with divergent clinical outcomes for epilepsy
onlinelibrary.wiley.com/doi/…
Gamaleldin osman retweeted
AI is transforming intracranial EEG (iEEG) and stereo-EEG into a precision platform for personalized epilepsy surgery planning, targeted neuromodulation, and continuous chronic monitoring.
doi.org/10.1002/epi.70461
#epilepsy
Gamaleldin osman retweeted
#Vagus nerve stimulation was associated with sustained seizure reductions in people with drug-resistant #epilepsy in the prospective CORE-VNS study.
At 36 months, median seizure frequency decreased 76%, with fewer seizure-related hospitalizations and ED visits.
ow.ly/5w9T5104K3K
@AmEpilepsySoc @livanova
Gamaleldin osman retweeted
[Epilepsy] Toutant et al.: "Spike morphology changes significantly across sleep-wake stages." sciencedirect.com/science/ar…
Gamaleldin osman retweeted
Advances across neurotech (including today's chemogenetics!) have convinced me that powerful treatments for devastating brain conditions are possible.
The next frontier is making them massively scalable, without requiring 10-hour brain surgery.
Today, my team and I at @ARIA_research are announcing 10 teams we're backing with £50m to tackle this challenge.
A thread 🧵 on their exciting projects!
Gamaleldin osman retweeted
Three people with epilepsy resistant to drug treatment saw the number of seizures they had per month fall by more than 90%, after gene-laden viruses were infused directly into their brains
go.nature.com/3WrLS8G
Gamaleldin osman retweeted
Clinical chemogenetics
nejm.org/doi/full/10.1056/NE…
Gamaleldin osman retweeted
Late HELPS2B score and restricted diffusion on magnetic resonance imaging are associated with neurological deficits after status epilepticus in a remote or chronic cohort - Ohno et al. - Epilepsia -
onlinelibrary.wiley.com/doi/…
Gamaleldin osman retweeted
#EpilepsySurgery has changed. The guidance has, too.
The new AES/CNS guideline is the first comprehensive update to epilepsy surgery recommendations in more than 20 years.
See what clinicians can expect: hubs.li/Q04CTwSr0
#AESinAction #EpilepsyAwarenessMonth
Gamaleldin osman retweeted
Cenobamate in Focal-Onset Refractory and Super-Refractory Status Epilepticus: A Multicenter Cohort Study With Matched Analysis
neurology.org/doi/10.1212/WN…
Gamaleldin osman retweeted
Key point: "Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show neutral to protective seizure associations at the population level, but do not necessarily capture individual risk."
Read this full-access critical review from @EpilepsiaJourn at doi.org/10.1002/epi.70527.
ALT Key point: "Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show neutral to protective seizure associations at the population level, but do not necessarily capture individual risk." Read this full-access critical review from Epilepsia Journal at doi.org/10.1002/epi.70527.
Gamaleldin osman retweeted
From Genetics to Function as we explore precision genetics, gene therapy, and memory and language outcomes following epilepsy surgery.
@CNS_Update #CNS2026 #2026CNS @IsaacYangMD @UCLANsgy @UCLA_ENT @UCLAHealth @dgsomucla @HarborUCLA @HarborUCLASurg @HarborTrauma
Gamaleldin osman retweeted
Developmental rate was significantly higher during the first postoperative year than during later follow-up, suggesting a biphasic postoperative developmental trajectory.
doi.org/10.1002/epi.70543
#epilepsy
Gamaleldin osman retweeted
Rethinking epilepsy surgery with Dr. Wes Phillips with how the genetic foundations of epilepsy can transform decision-making and treatment. @IsaacYangMD @CNS_Update #CNS2026 #2026CNS @UCLANsgy @UCLA_ENT @UCLAHealth @dgsomucla @HarborUCLA @HarborUCLASurg @HarborTrauma
Gamaleldin osman retweeted
An engaging discussion at #CNS2026 exploring how to optimize neuromodulation strategies in pediatric patients and when to consider #LITT for MTLE.
@CNS_Update #2026CNS @IsaacYangMD @UCLANsgy @UCLA_ENT @UCLAHealth @dgsomucla @HarborUCLA @HarborUCLASurg @HarborTrauma
Gamaleldin osman retweeted
This represents the inaugural study from the Device-Based Neuroelectronics Lab at Mayo Clinic Arizona. We are driven to create a future where neuromodulation is more effective and reliable at reducing seizures for our patients with drug resistant epilepsy. Thank you to @BernardBendokMD and @NREFORG for support of this research. @MayoClinic
Mayo Clinic researchers have detected measurable changes in the brain within 18 minutes of deep brain stimulation (DBS) in people with drug-resistant epilepsy, a finding that could eventually help clinicians personalize treatment without waiting months to determine whether stimulation settings are effective.
Learn more: mayocl.in/4z6FoKd
Gamaleldin osman retweeted
New clinical study. Published in @Brain1878
181 patients with LGI1-antibodies. #encephalitis. Multi-centre. International colleagues. Real world approach.
academic.oup.com/brain/advan…
3 of our Questions:
1. Which drugs / features associated with improved short term, disability and relapse outcomes?
2. Can we effectively re-threshold the modified Rankin Score (mRS)?
3. Do relapses associate with persistent disability and are there novel relapse biomarkers?
Our Main findings:
1. Seizures
- Stop with corticosteroids, plasma exchange. Not ASMs or IVIG.
- Recur with oral steroid (not ASM) weans
2. Long term disability (by mRS) - Can be re-thresholded to better reflect patient rated QoL (0-1, not 0-2)
- doing this, generates associations with immunotherapy timing: each day of delay matters, although not the specific immunotherapy
3. Relapses
- were common (37% of patients)
- associated with stepwise increases in mRS and greater overall disability
- rituximab associated with reduced relapse risk
- were associated with LGI1-IgM
We were very pleased with the depth (summarised in 8 main and 22 supplementary figures / tables) and detail of analyses
Collaboration with many including some on X @darshi_r @MackrillSamuel @antibodypad @Benjamin_Trewin
Gamaleldin osman retweeted
Paper accepted. Soon out in Epilepsia 🥳🥳🥳
🚨New preprint out: A novel diagnostic intracranial EEG biomarker in MOGHE medrxiv.org/content/10.64898…. Great multi-center interdisciplinary study with clinical impact. #epilepsy @IlaeWeb
Gamaleldin osman retweeted
The CNS, in collaboration with AES, has published a NEW evidence-based guideline on epilepsy surgery. This is the first comprehensive update in more than two decades addressing the surgical treatment of drug-resistant epilepsy in adults and children. Read more in Neurosurgery: bit.ly/3UIEKUV
#CNSGuideline #epilepsy #neurosurgery
