@janisl98

Ph.D. candidate at Edge Lab @USC | dancer. Pop gen & comp bio, with some ancient DNA hopefully. Meet my Chinese name 刘君健 (Liu Junjian)

 Los Angeles, CA
Joined June 2023
  • Tweets13
  • Following103
  • Followers60
James Lee and @DamienMorris have an interesting perspective paper out describing "some far-reaching conclusions" about the genetics of intelligence. This type of "where are we now" paper is very fun and more people should write them! So, where are we now? 🧵
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My paper about type I error rates in Qst/Fst comparisons is now published in @GeneticsGSA. Check it out here: academic.oup.com/genetics/ad…

Error rates in QST–FST comparisons depend on genetic architecture and estimation procedures

Abstract. Genetic and phenotypic variation among populations is one of the fundamental subjects of evolutionary genetics. One question that arises often in

academic.oup.com
Doc Edge@DocEdge852 Nov 2024
New work from my lab, led by graduate student @janisl98. Janis studied type I error rates in Qst/Fst comparisons (1/n, link to preprint below)
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Janis Liu retweeted
Doc Edge@DocEdge852 Nov 2024
New work from my lab, led by graduate student @janisl98. Janis studied type I error rates in Qst/Fst comparisons (1/n, link to preprint below)
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In this preprint with Arun Durvasula, we discuss how there is no evidence for a bottleneck in the panmictic ancestral population of humans ~ 1 million years ago, as was suggested by Hu et al in Science last year biorxiv.org/content/10.1101/…

Insufficient evidence for a severe bottleneck in humans during the Early to Middle Pleistocene...

A recently proposed model suggests a strong bottleneck in the panmictic ancestral population of modern humans during the Early to Middle Pleistocene transition. Here, we show this model provides a...

biorxiv.org
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It was recently reported that Africans experienced a sharp, severe bottleneck around 900kya and that this signal is absent in non-Africans. Here, we present evidence to show why this is likely a statistical artifact: @ras_nielsen @yun_s_song biorxiv.org/content/10.1101/… 1/4

A previously reported bottleneck in human ancestry 900 kya is likely a statistical artifact

It was recently reported that a severe ancient bottleneck occurred around 900 thousand years ago in the ancestry of African populations, while this signal is absent in non-African populations. Here,...

biorxiv.org
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Excited to share this new preprint with @spence_jeffrey_ and @DocEdge85 in which we developed a method to infer demographic history and mutation rates from millions of genomes, and applied it to gnomAD v4 data. Read on for a brief thread! biorxiv.org/content/10.1101/…

Estimation of demography and mutation rates from one million haploid genomes

As genetic sequencing costs have plummeted, datasets with sizes previously un-thinkable have begun to appear. Such datasets present new opportunities to learn about evolutionary history, particularly...

biorxiv.org
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Janis Liu retweeted
Doc Edge@DocEdge8531 May 2024
Second preprint from my group today---this one is led by @feriel_ouerghi_ . In this one, we discuss a previously proposed method for building forensic likelihood ratios from sequencing reads (1/n)
bioRxiv Genetics@biorxiv_genetic30 May 2024
On forensic likelihood ratios from low-coverage sequencing biorxiv.org/cgi/content/shor… #biorxiv_genetic
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Doc Edge@DocEdge8530 May 2024
Two new preprints from my group today---this one was led by @Dandan_Peng with an assist from Obadiah Mulder. Dandan benchmarked a bunch of leading ARG-estimation methods with respect to a specific goal (1/n)
bioRxiv Genetics@biorxiv_genetic30 May 2024
Evaluating ARG-estimation methods in the context of estimating population-mean polygenic score histories biorxiv.org/cgi/content/shor… #biorxiv_genetic
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I'm excited to share this new preperint with @mwpen and @DocEdge85 about the unifying mapping approaches within and between species biorxiv.org/content/10.1101/…

Unifying approaches from statistical genetics and phylogenetics for mapping phenotypes in structu...

In both statistical genetics and phylogenetics, a major goal is to identify correlations between genetic loci or other aspects of the phenotype or environment and a focal trait. In these two fields,...

biorxiv.org
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Eugenic movement and scientific racism: past, present, and future #TAGC24 panelists: Katrina Claw, Nathaniel Comfort, Steven Farber, Daniel HoSang, and @Jazlyn_Mooney
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Janis Liu retweeted
Xiran Liu@Xiran_L7 Mar 2024
Second time at #TAGC24/PEQG! Presenting a poster tonight (785T) on my PhD work with @NoahARosenberg on mathematical properties of allele-sharing dissimilarities (and how they explain phenomena observed in human population-genetic data)! Part 1 paper at doi.org/10.1515%2Fsagmb-2023…
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Trait differences Q_{ST} and F_{ST} Details can deceive (Janis Liu, "Error rates in Q_{ST} vs. F_{ST} comparisons depend on genetic architecture") #sciku #evol2023 @janisl98
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So happy to have my first talk and make new friends at #evolution2023 !
Feriel Ouerghi@feriel_ouerghi_25 Jun 2023
The Edge Lab absolutely killed it at #evolution2023. So proud! @janisl98 @Dandan_Peng @ObadiahMulder @DocEdge85
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