Inserm Research Director & Editor-in-Chief of Oncogenesis studying how tumor metabolism shapes anti-tumor immunity and cancer therapy resistance.
Nice, France
Joined April 2012
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Jean-Ehrland Ricci retweeted
Reminder that xCT-driven cell death (for instance induced by glucose deprivation) does not mean disulfidptosis,
That iron-dependent cell death does not equal ferroptosis,
That cysteine toxicity does not mean ferroptosis even if it's iron-dependent,
etc
nature.com/articles/s42255-0…
Jean-Ehrland Ricci retweeted
Check how this study reveals that STC1 is a key regulator of GSC phenotypic plasticity and aggressiveness through the NOTCH1/STAT3/GFPT2/O-GlcNAcylation pathway, suggesting that targeting STC1-associated signaling networks may represent a potential therapeutic strategy for GBM.
Jean-Ehrland Ricci retweeted
“Stanniocalcin 1 contributes to glioma stem cells phenotypic plasticity through NOTCH1/STAT3/GFPT2 axis”
🔵 Shuo Xu‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how their findings establish a novel Testican-1/Wnt/β-catenin axis driving CRC tumorigenesis and progression, positioning it as a promising therapeutic target to overcome Wnt-mediated progression and resistance.
Jean-Ehrland Ricci retweeted
“Testican-1 activates Wnt/β-Catenin signaling to drive colorectal cancer progression”
🔵 Nathaniel Weygant‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how, in this study, they revealed that CYBRD1 is a druggable transmembrane protein in HGSOC whose RUNX1-driven, Tyr252-dependent activation of JAK2/STAT3 promotes tumor progression and cisplatin resistance.
Jean-Ehrland Ricci retweeted
“CYBRD1 is transcriptionally regulated by RUNX1 and mediates JAK2/STAT3 signaling activation during ovarian cancer progression”
🔵 Jingxin Cheng‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
Mitophagy is everywhere in cancer reviews but rarely studied in vivo. We tracked it during lung tumor development and show that PINK1-dependent mitophagy is activated early during transformation and is a targetable vulnerability in KRAS lung cancer.
science.org/doi/10.1126/scia…
Jean-Ehrland Ricci retweeted
This review highlightes how genetic alterations influence metabolic phenotypes, how insights from therapeutic efforts targeting individual metabolic branches can inform a unified strategy to exploit metabolic weaknesses and guide the rational development of combination therapies.
Jean-Ehrland Ricci retweeted
“Metabolic vulnerabilities in pleural mesothelioma”
🔵 Pleased to share the latest review from Cristina Muñoz-Pinedo (@crismunozp) & Ernest Nadal (@apoptosislab ), now available in #Oncogenesis.
▶️ Read the full review in open access here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
The authors synthesise current knowledge into a conceptual model and highlight nucleotide metabolism as a central, drug-responsive nexus linking oncogenic signalling to malignant proliferation.
Jean-Ehrland Ricci retweeted
“The oncogenic control of nucleotide synthesis”
🔵 Excited to share the latest review from Issam Ben-Sahra (@bensahralab), now available in #Oncogenesis.
▶️ Read the full review here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how the authors uncovered a metabolic-epigenetic signaling cascade in the lung tumor microenvironment whereby tumor-derived lactate activates CAFs and enables them to induce an immunosuppressive macrophage phenotype via exosomal miR-214-5p.
Jean-Ehrland Ricci retweeted
“Lung adenocarcinoma cell-derived lactate activates CAFs to promote macrophage M2 polarization via exosomal miR-214-5p”
🔵 Bin Li‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Moving beyond empiric therapy towards strategic metabolic targeting offers an opportunity to enhance outcomes for patients with this aggressive and diverse lymphoma.
Jean-Ehrland Ricci retweeted
Check how this review provides evidence that metabolic heterogeneity of DLBCL, shaped by distinct genetic drivers, microenvironmental pressures, and therapeutic interventions, represents a critical yet underexploited dimension of tumour biology.
Jean-Ehrland Ricci retweeted
“Metabolic vulnerabilities and therapeutic opportunities in diffuse large B-cell lymphoma”
🔵 Excited to share the latest review from Marie Anne-Catherine Neumann and Christian Frezza, now available in #Oncogenesis.
▶️Read the full review here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how their findings reveal a novel CAFs/PTGDS-PAQR9-MAPK signaling axis that promotes neuroendocrine differentiation and drives pancreatic ductal adenocarcinoma progression, offering new therapeutic opportunities to overcome stromal-mediated chemoresistance.
Jean-Ehrland Ricci retweeted
“CAF-derived PTGDS drives pancreatic cancer neuroendocrine differentiation and chemoresistance via PAQR9-MAPK”
🔵 Yuchong Zhao‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how the combinatorial strategy composed of ALK inhibitors and a new EGFR-targeting ADC for the treatment of ALK-rearranged and EGFR-overexpressing NSCLC exerts its pharmacological synergism through the activation of the mitochondria-mediated caspase cascade and the UPR.