@junwei_s

Associate Professor at UPenn

 Philadelphia, PA
shipennlab.wixsite.com/shi-lab
Joined March 2013
  • Tweets417
  • Following510
  • Followers1.1K
5Media
One more thing. Another work led by the dedicated and talented scientists @DiqiuR and Shangshang Wang, stemming from our long-standing collaboration with Rahul Kohli and @andyjminn’s labs at Penn. nature.com/articles/s41587-0…
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Very excited to get this new work by Shin Ngiow up on #bioRxiv. We may be blocking PD-1 too long causing detrimental effects on Tpex cells. A drug holiday approach may be beneficial. Also some cool new Tpex biology here. #immunopharmacology biorxiv.org/content/10.64898…
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Inducible, split base editors for in vivo cancer functional genomics go.nature.com/4tfu1xi
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A high-resolution tiling base editing mutagenesis screen targeting Adar1, an adenosine deaminase associated with tumor immunity, identified both loss-of-function and gain-of-function alleles.
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Our improved, inducible base editing system (seBE) provides controllable and robust genome editing to systematically identify functionally relevant key residues for cancer functional genomics.
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Have been missing twitter. Excited to share our new study. This was a close collaboration with Kathrin Bernt's and @KaiTanLab1 labs, led by the talented and unstoppable @TomZhendong and Sixiang Yu cell.com/molecular-cell/full…

CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid...

Direct CRISPR functional genomics in primary patient samples holds promise for therapeutic target validation and discovery. Cao et al. develop an optimized CRISPR platform for genetic screening in...

cell.com
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CRISPR knockout screens reveal both shared and distinct AML dependencies in primary samples. CRISPRi screens identify essential cis-regulatory elements in PDXs. We further used Perturb-seq to dissect regulatory networks and cellular heterogeneity in primary AML cells.
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This robust and general CRISPR-based functional genomics approach in primary AML patient samples opens up new opportunities to prioritize/identify therapeutic targets and understand resistance mechanisms in AML.
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ft. @TomZhendong, S. Yu, Y. Liu, L. Liu, @junwei_s (@Penn_CBIO/ @PennEpiInst), @jackiejpeng (@UPennGCB), D. Barrett, J. Sussman, C. Chen, A. Thadi, F. Alikarami, J. Xu, @cdktmw, @kathrinbernt (@CHOP_Research) & Martin Carroll (@PennCancer) @CAMBUpenn cell.com/molecular-cell/full…
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Healthy blood cells can live without ARHGAP45—but acute myeloid leukemia cells can’t. 🩸 Junwei Shi, PhD, Associate Professor of Cancer Biology (@junwei_s) and team show a CAR T + CDC42 inhibition strategy could target AML with minimal side effects. bit.ly/45OyXQu
Healthy blood cells and cancer cells illustration.

ALT Healthy blood cells and cancer cells illustration.

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Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies ft. Yuqiao Liu & @junwei_s (@Penn_CBIO) @CD_AACR aacrjournals.org/cancerdisco…
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Excited to share our new study, in close collaboration with @AbdelWahablab and @DaniyanMd led by the exceptionally talented scientists @PuZhang09980432 and @TomZhendong doi.org/10.1158/2159-8290.CD…

Systematic Evaluation of GAPs and GEFs Identifies a Targetable Dependency for Hematopoietic...

Unbiased genetic screens identify the minor antigen ARHGAP45 as a selective dependency across blood cancers that spares normal blood cells and can be targeted by TCR-CAR T cells in combination with...

aacrjournals.org
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Even more exciting: CDC42 inhibition not only synergizes with ARHGAP45 loss intrinsically in leukemia cells, but also enhances TCR-CAR T cell function. A dual strategy to target cancer cells and augment immune responses.
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This has truly been a fantastic collaboration that I can only dream of @AbdelWahablab, @DaniyanMd, @TomZhendong, and @PuZhang09980432
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Replying to @junwei_s @AbdelWahablab @DaniyanMd @PuZhang09980432 @TomZhendong @ChrisVakoc
This has truly been a fantastic collaboration that I can only dream of @AbdelWahablab, @DaniyanMd, @TomZhendong, and @PuZhang09980432
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