Biologist at Scripps, PhD at Stanford. Dynamics of genomes and cells.
San Diego, CA
Joined February 2015
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Our paper is out in @Nature! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11
nature.com/articles/s41586-0…
King L Hung retweeted
Excited to share that my PhD work is now officially published in Cell!
Grateful to all the coauthors, collaborators, and everyone who helped bring this work across the finish line 🙏
Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung!
cell.com/cell/fulltext/S0092…
King L Hung retweeted
Excited that my PhD paper is out in @NatureMedicine where we developed a new method called uRARE-seq. Summary by my amazing PhD mentor @max_diehn below.
Excited to share our new study describing uRARE-seq, a tumor-naive #LiquidBiopsy method for analyzing urine cell-free RNA (cfRNA) in #BladderCancer and other genitourinary cancers. Out today in @NatureMedicine 🧵 1/16 rdcu.be/bRoXk7REWtRa
King L Hung retweeted
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science.
Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com/articles/s41586-0…
King L Hung retweeted
Congrats to postdoctoral fellow King Hung (@kinglhung) on being named a Damon Runyon Fellow, supporting research on how cells communicate to coordinate tissue behavior, a process disrupted in cancer. Using flatworms, he studies how physical and biochemical signals guide regeneration through live-cell tracking. More: ow.ly/qJil50YLhPY
Happy to receive funding from Damon Runyon Fellowship / HHMI for the next 4 years! We're working on some fundamental questions in tissue biology and I'm excited to share more soon. Grateful to @ardemp for the mentorship!
damonrunyon.org/news/damon-r…
King L Hung retweeted
So excited to see our work profiling the tumor microenvironment in triple negative breast cancer out @NatureCancer! Please give it a read, super proud of this one :)
For a full description of what we found, see below for a detailed tweetorial. nature.com/articles/s43018-0…
I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) biorxiv.org/content/10.1101/…
King L Hung retweeted
Most people eat small (~1-2% body weight) and frequent (2-3x/day) meals. But Burmese pythons 🐍🐍 can fast for >1 yr and eat 100% of their weight in a single meal. What happens in snakes after eating? What lessons they can teach us about human physiology? biorxiv.org/content/10.64898…
King L Hung retweeted
Now online! EcDNA-borne structural variants drive oncogenic fusion transcript amplification dlvr.it/TQClG0
King L Hung retweeted
Stanford Medicine researchers found that tiny cancer-linked DNA circles “hitchhike” on chromosomes to spread during cell division. Blocking this attachment may offer a new avenue for future cancer therapies.
med.stanford.edu/news/all-ne…
ALT Stanford Medicine: Cancer-promoting DNA circles hitchhike on chromosomes to spread to daughter cells
Very nice news coverage on my scientific journey by Christie Wilcox in @ScienceMagazine and #ScienceAdviser: science.org/content/article/…
This was probably one of my crazier ideas early in grad school and was such a fun project to work on. Check out this awesome short video from @JuliaBauman2 highlighting this work!
ecDNA biology is one of those weird, fascinating corners of bio that hook me every time there's a new result. So I loved reading about this one from @HowardYChang & Paul Mischel's labs in @Nature.
Very interesting implications for design of non-diluting, non-integrating gene therapy vectors!
Great work Venkat & @kinglhung 😀
King L Hung retweeted
My lab is recruiting postdoc candidates interested in CRISPR synthetic biology and functional genomics approaches to study and engineer tissue injury responses! hsiunglab.org
King L Hung retweeted
Tremendous work by @kinglhung and @HowardYChang ! This recent discovery answers the most critical question on ecDNA maintenance! @Nature Are you a non-scientist? No worries! Check this non-scientist-friendly summary! rdcu.be/eQMvM
Nature research paper: Genetic elements promote retention of extrachromosomal DNA in cancer cells
go.nature.com/4pkUpDE
Nice feature article from @_eunhee_yi_ and Noah Dusseau about our work: nature.com/articles/d41586-0…
Our paper is out in @Nature! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11
nature.com/articles/s41586-0…
King L Hung retweeted
Nature research paper: Genetic elements promote retention of extrachromosomal DNA in cancer cells
go.nature.com/4pkUpDE
Overall, we propose that ecDNA is not only selected in cancer because of oncogenes, it is also actively retained because of retention elements, allowing it to persist in a growing cancer cell population. 10/11
It was great mentoring and working with Venkat Sankar on this project. Also great working with @HowardYChang, Paul Mischel, Aditi Gnanasekar, Ivy Wong, and other collaborators on this project. 11/11