@TampereUni Lab head of the Intestinal Signalling and Epigenetics (ISE) research group. Laboratory Chief. Dad. Roadcyclist
Tampere University
Joined September 2010
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🙏Three oral presentations and one moderated poster from the Intestinal Signalling and Epigenetics group @UEGW2024. It was nice to see so many interesting presentations about celiac disease.
Thank you UEG for hosting us! #UEGWeek2024,@my_UEG
🎓😊 Congrats Valeriia Dotsenko from the Intestinal Signalling and Epigenetics group at the Celiac Disease Research Center for her PhD! Thanks to Associate Professor Iris Jonkers for the engaging discussions.🎉
@celires_tau @TampereUniMET @JonkersIris @TampereUni
Happy to share our paper out in Nature Immunology! Here we provide molecular level evidence that inhibiting transglutaminase 2 (TG2) is a very promising strategy to treat celiac disease (CeD).
nature.com/articles/s41590-0…
#celiacdisease
#ZED1227
@celires_tau
@TampereUniMET
@TampereUni
4/5
We discovered that the dose of human leukocyte antigen (HLA)-DQ2 or -DQ8 genetic background contributed significantly to the efficacy of ZED1227 in improving mucosal architecture and protecting the epithelium from the IFN-γ response, latter modelled in intestinal organoids.
3/5
It’s proposed that gluten peptides have innate immune properties leading to epithelial stress. Our data challenge this by showing that deamidated gluten-induced adaptive immunity is a sufficient step to set the stage for CeD pathogenesis.
2/5
We discovered that, during the gluten challenge, TG2 inhibitor, ZED1227, preserved transcriptome signatures associated with mucosal morphology, inflammation, cell differentiation, and nutrient absorption to the level similar of the patients on gluten-free diet.
1/5
Background: TG2 plays a pivotal role in the pathogenesis of CeD by deamidating dietary gluten peptides, which facilitates antigenic presentation and a strong anti-gluten T cell response.
Keijo Viiri retweeted
#väitös perjantaina !
Mikko Oittisen väitöskirja suolen #kantasolujen epigenetiikasta tarkistetaan 31.5.2024 klo 11 🧬 tuni.fi/fi/ajankohtaista/mik…
#postdocjobs available in my lab at Tampere Uni Finland to work on intestinal organoids to model environmental causes behind #celiacdisease and to molecularly assess the treatment efficacy in some very promising clinical trials!
tuni.rekrytointi.com/paikat/…
Thank you #DDW2022 San Diego, great conference yet again! Nice to see new advances in gastroenterology. See u next year.
Join #DDW2022 5/23 at 4pm PDT on my talk“TG2 Inhibitor Protects Gluten-Induced Intestinal Damage in Celiac Disease: Transcriptomic Analysis of a Randomized Gluten Challenge Study”. The work of @dotsdon from our lab!
@AmerGastroAssn #AGACouncil #Celiac @celires_tau @TampereUniMET
My humble gratitude to @skr_fi supporting our work! This facilitates studies on celiac disease pathogenesis and assessment of the developed strategies to treat the disease 🙏🙏
#skr2022 @TampereUniMET @celires_tau
skr.fi/ajankohtaista/lokakuu…
Keijo Viiri retweeted
We have a postdoc position available!
If you’re interested in #RNA or #chromatin and especially both together then please apply!
Deadline Feb 16th.
Link:atsv7.wcn.co.uk/search_engin…
Please retweet!
Congratulations Joel for the excellent defence of your PhD thesis! Special thanks also for the opponent prof. Riitta Lahesmaa for the lively discussions!
trepo.tuni.fi/handle/10024/1…
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@celires_tau
@TampereUniMET
@joejohns13
@LahesmaaGroup
@BioscienceTurku
@InFLAMES_Health
nejm.org/doi/full/10.1056/NE…
Very promising cure for celiac disease! Congratulations Markku Mäki et al.! #celiac #nejm @TampereUniMET
Happy to see our paper in press! PRC2 regulates the differentiation of intestinal M cells. Important gatekeepers in mucosal immunity. Congrats to Joel @joejohns13 and big thanks to our collaborators @KaikkonenLab and @PekkaKatajisto cmghjournal.org/article/S235…