PhD (Harvard) Establishing new principles of organic synthesis: Green Reaction Discovery, Protein Conjugation, Bio-inspired total synthesis of natural products
Singapore
Joined November 2020
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We introduce a new disulfide bond metathesis strategy using Koser's reagent as a radical initiator, enabling biocompatible, bidirectional reactions under mild conditions, with potential in drug development, protein engineering, and biomedical applications.
doi.org/10.1073/pnas.2405337…
We present an amine-differentiating amide synthesis using an sp-carbon-activated ester. The bulky TIPS group prevents unwanted reactions while allowing for easy removal, facilitating post-modifications like click reactions and peptide-drug conjugations.
doi.org/10.1126/sciadv.adp75…
Inspired by nature, we used water as both solvent and reagent in developing a metal-free deuteration catalyzed by triaryl carbenium ion-pair. This approach offers a sustainable alternative to traditional H/D exchange, addressing metal-related challenges.
doi.org/10.1002/anie.2024085…
Our new metal-free approach enables 1,3-addition of amines to α,β-unsaturated aldehydes without directing groups. By using iodine and an oxidant, it yields unsaturated α-amino acetals, crucial for synthesizing bioactive molecules and pharmaceuticals.
doi.org/10.1016/j.gresc.2024…
Achieve selective and efficient electrocatalytic benzylic C−H oxidation in air using the [Ph3C]+[B(C6F5)4]− ion-pair. Our method avoids overoxidation and the use of expensive oxidants while being tolerant of diverse functional groups. doi.org/10.1002/anie.2024065…
A new era for peptide synthesis using unprotected amino acids is coming! A phenomenal work by Zhao Junfeng, pioneering atom economic and pot economic peptide synthesis.
doi.org/10.1021/jacs.4c00314
Exploring the synthesis of seven-membered rings in natural products, highlighting advancements from Pauson-Khand to [5+2] cycloaddition reactions. This review showcases recent innovative strategies for constructing non-aromatic cycloheptane skeletons. doi.org/10.1016/j.cclet.2023…
Uracil-Cu catalyst utilizes copper's affinity for DNA/RNA, promoting cyclopropanol allylation without acidic activators or strong bases. This green method yields δ,ε-unsaturated ketones efficiently, with high E-selectivity and water as the sole by-product.
doi.org/10.1039/D3SC04890J
Presenting our 5th Generation Thiol-Specific Bioconjugating Reagent. Its additional silicon handle enhances chemo-selectivity and stability, while paving the way for novel drug release methods and bridging various scientific fields.
doi.org/10.1021/jacs.3c12050
Making Waves in Green Chemistry: Our team's relentless pursuit over 30 years to develop water-compatible reactions culminates in our latest account. Join us in thanking our incredible team and celebrating this milestone towards a more sustainable future.
doi.org/10.1021/acs.accounts…
Keith Fagnou's work has been a significant inspiration to many. It is our privilege to offer a short account on Photoredox-Catalyzed C(sp2)–H Bond Functionalization Reactions as part of a special issue dedicated to his memory.
thieme-connect.com/products/…
Congratulations to @ShenghanTeng and @jzhhua for developing a thiol-specific silicon-containing conjugating reagent!
doi.org/10.1002/anie.2023119…
Congratulations to Conghui Wang, Lei Xu, and @jzhhua for their review on recent applications of macrocycles in supramolecular catalysis!
doi.org/10.1016/j.cclet.2023…
Congratulations to Xiaoyu Zhang and Peizhong Xie for developing an organophotoredox/DABCO catalytic system for the fluoroalkylation of activated allylic acetates!
doi.org/10.1021/acs.orglett.…
Congratulations to Wubing Zeng and Peizhong Xie for developing an organophotoredox-catalyzed intermolecular formal Grob fragmentation of cyclic alcohols with activated allylic acetates!
doi.org/10.1021/acs.orglett.…
Congratulations to Ting Zhang and @jzhhua for developing a rare earth metal catalyzed aerobic dehydrogenation of N-heterocycles!
doi.org/10.1021/acs.orglett.…
Congratulations to Yao Zhao for developing a regioselective and geometrically controlled Heck 1,1-diarylation of unactivated aliphatic alkenes!
doi.org/10.1021/acs.orglett.…
Congrats to @ShenghanTeng for developing a new amine-specific bio-click reaction using alkynone β-trifluoroborates! Read our paper here in @ScienceAdvances:
science.org/doi/full/10.1126…
Thank you @MinSunKang5 for all your hard work in my group! All the best with your PhD journey in the US!
Congrats to @wanry1991 and @jzhhua for developing a metal-free strategy using a triaryl carbenium ion pair as a catalyst to generate β-carbolines from tryptamines and aromatic aldehydes @CellRepPhysSci doi.org/10.1016/j.xcrp.2023.…
