@laixinking

A Systems Biologist with passion for research, photograph, and cook.

 Finland
sites.google.com/view/lai-lab
Joined December 2009
  • Tweets190
  • Following183
  • Followers85
55Media
📢 Call for Papers! Our new Research Topic "Scalable and Interpretable Visual Analytics for Big Data" is now open for submissions in Frontiers in Bioinformatcs! 🧬💻 🗓️ Deadline: Nov 7, 2026 🔗 Submit here: frontiersin.org/research-top… #Bioinformatics #DataViz #BigData

Frontiers | Scalable and Interpretable Visual Analytics for Big Data

The field of bioinformatics is witnessing a dramatic surge in data volumes due to the advent of advanced high-throughput technologies in areas such as genomi...

frontiersin.org
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Xin Lai retweeted
ISCB News
@iscbMay 31
🚨Paper submissions to iscbAI are due tomorrow, Monday, June 1! 📥 Submit here: iscb-cn.org.cn/web/72/list.h…
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New research in @CMLS_Journal provides the first systematic look at SOX10-mediated miRNA regulation in Uveal Melanoma (UM). 🔗 Read the full study here: rdcu.be/fjbeA #UvealMelanoma #CancerResearch #SystemsBiology #miRNA #Bioinformatics #Oncology #PrecisionMedicine
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We develop #RingNet to visualize #multi-modal data in #networks. It is powerful to visualize your #cohort and #single-cell #omics data. All you need are the csv files for your data and networks, and RingNet can support svg, pdf output. Try it out at fip-128-214-252-149.kaj.pout…
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The Biorxiv preprint is available at doi.org/10.64898/2026.01.20.…
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The latest research from Guo's lab at @theNCI shows that one hotspot mutation in #DICER1's RNase IIIb can lead to loss and gain of function 5p-miRNA and the gain of function of 3p-miRNA. rdcu.be/eUxiq
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See our new preprint, where we used a network biology method to identify novel therapeutic targets for uveal #melanoma. #networkmedicine #bioinformatics #cancer
bioRxiv Cancer Bio@biorxiv_cancer15 Oct 2025
A computational SOX10 network-based selection strategy to identify new drug targets in uveal melanoma biorxiv.org/content/10.1101/… #biorxiv_cancer

A computational SOX10 network-based selection strategy to identify new drug targets in uveal...

Uveal melanoma (UM) is the most common intraocular malignancy in adults. In contrast to cutaneous melanoma (CM), effective treatment options for metastatic UM are limited. The transcription factor...

biorxiv.org
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Seedless binding in #miRNAs can also lead to gene repression as shown with miR-155 and miR-124, though this unconventional binding accounts ~1% of miRNA binding. See Bartel lab's new paper for details. Functional microRNA targeting without seed pairing academic.oup.com/nar/article…
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New preprint on IDH-mutant #astrocytomas: We analyzed rare patient samples showing grade 2-3→4 progression post-therapy. Key findings: #ncRNAs drive astrocyte dedifferentiation; tumor suppressor #miRNA let-7b-3p shows recurrent deletions; #lncRNA NEAT1 regulates ECM organization
bioRxiv Cancer Bio@biorxiv_cancer2 Oct 2025
Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment progression of IDH-mutant astrocytomas biorxiv.org/content/10.1101/… #biorxiv_cancer

Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment...

IDH-mutant (IDHmut) astrocytomas typically arise as grade 2–3 tumors, but a subset of them progress to grade 4 after treatment, significantly worsening the prognosis. It is unresolved how noncoding...

biorxiv.org
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New publication at #Bioinformatics of @OxfordJournals. HallmarkGraph: a cancer hallmark informed graph neural network for classifying hierarchical tumor subtypes #CancerResearch #MachineLearning #AIinMedicine #PrecisionOncology academic.oup.com/bioinformat…

HallmarkGraph: a cancer hallmark informed graph neural network for classifying hierarchical tumor...

AbstractMotivation. Accurate tumor subtype diagnosis is crucial for precision oncology, yet current methodologies face significant challenges. These includ

academic.oup.com
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more replies
We built HallmarkGraph to be transparent. By integrating gene-level features with cancer hallmarks, we can now provide clear explanations for our model's predictions. #InterpretableAI #ComputationalOncology #MedicalAI
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Our commitment to open science means the HallmarkGraph data and code are publicly available on #GitHub and #Zenodo. #OpenScience #FAIRdata #Research #GitHub #DataSharing github.com/laixn/HallmarkGra… doi.org/10.5281/zenodo.15790…
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The 2nd China-Germany-Finland Life Sciences Forum, held at Tampere University, has successfully concluded. The forum brought together 60 researchers from five countries. The forum focused on AI in biomedical research and health data science innovation. tuni.fi/en/news/internationa…
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The second day's session on the digitization of health benefited greatly from the participation of high-level government officials and Chinese and Finnish companies, including @avaintec , @AtostekOy , SOENIA®, @NADMED_Ltd, 神州医疗.
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The forum's emphasis on translating academic research into practical applications through industry partnerships reflects the urgent need for scalable, data-driven healthcare solutions that can be deployed globally to improve patient outcomes and population health management.
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Just published!🦠 Repurposed #clindamycin suppresses #pyroptosis in tumor-associated macrophages through Inhibition of caspase-1 Open access🔓 jeccr.biomedcentral.com/arti… #DrugRepurposing #TumorAssociatedMacrophages #Immunotherapy #UvealMelanoma
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🧬 Successfully organized #ISBRA2025 in @helsinkiuni with @NetPharMed! 167 submissions across #bioinformatics & #computationalbiology → 66 high-quality papers selected for #LNBI proceedings. Thanks to all participants for making this international symposium exceptional! 🇫🇮
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The conference proceedings can be found at: link.springer.com/book/10.10…

Bioinformatics Research and Applications

link.springer.com
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