@MarcusDGon

MD/PhD Endocrinologist Scientist. Cancer metabolism, cachexia, insulin, PI3K, diabetes, obesity. GI Villi lover. Metabolic Consulting. NYJ/NYY/NYCFC/NYK fan.

 New York
goncalveslab.com/
Joined April 2009
  • Tweets7K
  • Following770
  • Followers2.9K
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New paper out in @cellpressblue ! We found that reintroducing refined starch after weight loss activates the innate immune system through the complement pathway, while sugar has the opposite effect. With @eze_dantas , @davidludwigmd , CaraEbbeling, @CantleyLab , and team. 🧵
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New at #ESMO2026 AVEO's anti-GDF-15 antibody, rilogrotug. Phase 1b dose escalation (NCT05865535), 50 to 800 mg alongside standard cancer therapy. Weight gain and improved appetite through week 12 at all doses. @MDRoeland @OHSUKnight
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No DLTs. No TEAE led to discontinuation, dose reduction, or death.
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Impressive weight loss reversal.
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The sooner the better.
Ethan Mollick
@emollickOct 23
By every measure, Opus 4.8 beats human experts as peer reviewers in a study of 124 Harvard social science papers covering a range from statistical analyses to formal models to qualitative work. As academics, we need to figure out how to adapt the practice of science to AI, fast.
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The wirelessly powered device can be linked to a clinically available continuous glucose monitor to catalyze the conversion of glucose to gluconate, which is then renally excreted. doi.org/10.1126/science.aem0…

Putting glucose metabolism under electronic control

An electronic device controls the redox mechanisms that regulate glucose concentrations in mice

science.org
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Weight loss during intermittent fasting, not Mediterranean diet quality alone, is associated with lower inflammation: A randomized controlled trial sciencedirect.com/science/ar…
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Marcus Goncalves retweeted
Eric Topol
@EricTopolOct 21
Retatrutide, the most potent GLP-1 agent in this family of drugs to date, had a marked benefit vs sleep apnea in a randomized trial, in people with obesity, just published @NEJM AHI-apnea-hypopnea index nejm.org/doi/full/10.1056/NE…
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Gut-derived glucagon-like peptides attenuate T cell-induced intestinal injury cell.com/cell-reports-medici…

Gut-derived glucagon-like peptides attenuate T cell-induced intestinal injury

Koehler et al. demonstrate distinct physiological roles for GLP-1R and GLP-2R signaling in protecting the intestine from αCD3-induced enteropathy. Conversely, GLP-1R/GLP-2R agonists, administered...

cell.com
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Marcus Goncalves retweeted
Nada Kalaany@nada_kalaanyOct 20
It maps throughout three #Cachexia stages -as defined in humans (Pre-CAC, Early-CAC and Late CAC), the evolution of #Polar and #Lipid metabolic networks in 10 different tissues in both #Male and #Female mouse models of pancreatic CAC.
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GDF15 suppresses liver inflammation via GFRAL-dependent glucocorticoids. cell.com/cell-metabolism/ful…

GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocort...

Growth differentiation factor 15 (GDF15) suppresses liver inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis (MASH), which is independent of reduced food intake, body...

cell.com
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Muscle-specific Miro1 deletion improves oxidative capacity and insulin sensitivity in mice and cells. nature.com/articles/s41467-0…

Miro1 mediates skeletal muscle insulin resistance in type 2 diabetes

Nature Communications - Insulin resistance in skeletal muscle contributes to type 2 diabetes (T2D), but its causes remain unclear. We identify the mitochondrial protein Miro1 as a key regulator of...

nature.com
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Mukund Iyengar
@mukundiyngrOct 19
In one of the hardest NCI funding cycles in decades, these institutions remained R01 powerhouses Full FY'26 dataset in 🧵 below MD Anderson: 131 R01s (55% of portfolio), UCSF: 91, , Penn: 83 (highest R01 %), MSK: 76 (37% R01s but heavy on K-awards) Across the top 20 institutions: 1,223 R01 records, which is ~36% of the national total Huge congrats to the PIs, labs & research teams keeping cancer discovery moving forward🎗️ - - - - - Source: NIH RePORTER via @Jori_health - - - - -
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Preprints: pre-conditioning with dietary restrictions- serine/glycine starvation or caloric restriction- limits cancer cachexia by establishing the normal protective response to nutrient limitation. @CancerGrand biorxiv.org/content/10.64898… biorxiv.org/content/10.64898…
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Glutamine + chemo in pancreatic cancer: Phase 1 GlutaPanc, n=16, 81% cachectic at baseline. 30g/day oral glutamine + full-dose gem/nab-paclitaxel, no glutamine DLTs. ORR 44%. nature.com/articles/s43018-0…

l-Glutamine in combination with first-line gemcitabine and nab-paclitaxel in advanced pancreatic...

Nature Cancer - In this open-label, single-arm, phase 1 GlutaPanc trial, Gong and colleagues report the safety and feasibility of l-glutamine in participants with advanced pancreatic ductal...

nature.com
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Caveats: single-arm, single institution, n=16, no control group. Authors say: this does not show glutamine + chemo beats chemo alone. OS follow-up still immature. Dose was supervised, clinical-grade. Interesting signal that needs an RCT.
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Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes lowers A1C and hyperglycemia nejm.org/doi/full/10.1056/NE…

Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes | NEJM

Continuous glucose monitoring (CGM) has been shown to be beneficial in persons with type 1 diabetes and others with insulin-treated type 2 diabetes, but its role in the treatment of persons with ty...

nejm.org
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Manganese availability determines hepatic insulin sensitivity by enhancing Akt activity, and fructose promotes hepatobiliary Mn excretion. jci.org/articles/view/200951
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AMP Deaminase-2 Activators and Regulators Underpinning Cellular Function in Human Fructose and Nucleotide Metabolism pubs.acs.org/abmcb8/article/…

AMP Deaminase-2 Activators and Regulators Underpinning Cellular Function in Human Fructose and...

Abstract. AMP deaminase (AMPD) plays an integral role in fructose metabolism via its regulation by ATP, GTP, and phosphate (Pi). The fructose catabolic pat

pubs.acs.org
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Marcus Goncalves retweeted
Keshari Lab@KeshariLabOct 2
Congrats to @Nancy_T_S for pulling together and leading this great collaborative effort between our lab and @JustinPerryPhD! Here we build more on the concept of metabolic symbiosis… science.org/doi/10.1126/scia…

Macrophage-supported metabolic adaptation drives tumor survival under nutrient stress

Triple-negative breast cancer (TNBC) develops in hypoxic, nutrient-limited tumors enriched with macrophages and cell death. We show that metabolically distinct TNBCs differentially exploit macropha...

science.org
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Keto suppressed colon tumors but promoted small-intestine adenomas in mice, via dietary fat → FAO → PPAR, not ketones. Same diet, opposite effects by site. Diet-as-therapy must be tumor- and site-specific. @ohyilmaz nature.com/articles/s41586-0…

Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones

Nature - A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in...

nature.com
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I think I somehow missed this great paper from few months back.
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