
Scientific SuperIntelligence @periodiclabs
Joined October 2013
- Tweets600
- Following247
- Followers918
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Mark Huang retweeted
I asked people which neolabs under $10B have the highest talent density:
32 votes: Core Automation (@MillionInt, @_arohan_)
26 votes: Periodic Labs (@LiamFedus, @ekindogus)
20 votes: Flapping Airplanes (@spectorb, @amspector100, @aidanmantine)
18 votes: Standard Intelligence (@G413N, @devanshpandey)
8 votes: Ricursive (@annadgoldie, @Azaliamirh)
5 votes each:
- Ineffable (David Silver)
- Mirendil (@bneyshabur, @HarshMeh1a, @shayan_, @tararezaeikh)
- Recursive (@RichardSocher, @_rockt, @timshi_ai, @josh_tobin_, @CaimingXiong, @jeffclune, @tydsh, Alexey Dosovitskiy)
3 votes each:
- Applied Compute (@ypatil125, @rhythmrg, @lindensli)
- Isara (@ezhang7423, @hegasz)
- Prime Intellect (@vincentweisser, @johannes_hage)
2 votes each:
- Elorian (@AndrewDai, @yinfeiy, @SethInternet)
- Goodfire (@eric_ho, @DanJBalsam, @banburismus_)
- Inherent (@tantumscollins, @edwardfhughes, @LouisKirschAI, @kallyaleksiev)
- Trajectory (@rronak_, @QuantumArjun, @MichaelElabd)
- World Labs (@drfeifei, @jcjohnss, @BenMildenhall, @chlassner)
People couldn't pick a company they work at or founded. Disclosure: I'm a small investor in Applied Compute, Factory, Standard Intelligence, Trajectory and Wafer. I didn't vote.
Continued:
The model just wants to learn!
@periodiclabs is building the flywheel starting from the closed data loop.
The economics of a Neolab.
A neolab is loosely defined as a startup of AI researchers who raises a lot of money pre-production to be able to finance GPU compute to take on a large AI problem.
To buy 1000 GB300s or ~14 NVL72 racks will set you back $125-150M for 3yrs with 15-30% upfront. That’s about ~2-2.5MW.
Thats about enough to do 10^25 flops a quarter and get to a GPT-4 level model which is 1-2 OOMs off frontier for pretraining.
If you post-train on a great open source model, you have a better chance of getting to frontier. The risks are a) you need to spend millions on RL environments too and b) being lapped by another model release while being tied to a base model.
For this to payback, you need to give your customers a better and ideally cheaper inference service than a base model and serve them for long enough to recoup your large investment. Even at 50% margin on inference, to recoup $10M in training means serving ~10T tokens (!) if you price like Fable / Astra given a standard cache read / input / output split ($2/M blended). And you have to justify being better than a release like Opus 5.5 which is even cheaper. Often, you end up charging your customers a huge premium in terms of platform fees and compute fees on top of pure inference.
Meanwhile, every hour you’re not utilizing your GPUs you are burning money so you typically resell this compute back to a broker or run inference for open models / resell spot instances. At below a ~60% utilization on spot, you will still lose money.
Add to that insane cost of talent.
So what can you do with the compute?
- Not play the model game at all.
- Play an entirely different model game (Jev, World Labs) that if big labs played, would either a) cannibalize their business or b) be incrementally not significant revenue c) would cause too much distraction from the main main thing
- Acquire a proprietary data set (Peridodic Labs) in enough volume in a domain of usefulness to eclipse frontier quality. Often happens in robotics, biology, chemistry.
If you do overcome the challenge of building a model that is useful and well priced beyond big labs models, given the huge price of compute, you still need to play in an area where the revenue / compute ratio is signficant and market demand is large enough to payback your compute spend.
It is a difficult game.
Neon’s scientific traces are long and vary widely in length. Training on them shouldn’t mean GPUs chewing through padding or waiting for each other.
Here’s how we pack sequences, balance the work, and distribute long contexts across GPUs at @periodiclabs 👇
periodic.com/news/ai-infrast…
Mark Huang retweeted
Another Neon infra tidbit: @periodiclabs accelerated checkpoint conversion ~30x down to just 1 minute, helping us deploy faster to get rapid feedback from our labs.
Our models train in Megatron, but SGLang inference consumes weights in HuggingFace format. Traditionally, conversion ran serially:
1. rebuild the entire checkpoint from individual weight tensors
2. convert the checkpoint
3. reshard it to be inference-ready
This could take 30 min for a trillion parameter model!
Noticing that conversion shouldn't require materializing the full checkpoint, @hsu_byron introduced Fast Resharding:
1. parallelize conversion across Ray actors
2. convert expert chunks directly instead of assembling the full expert tensor in memory
We upstreamed Fast Resharding to Miles in PR #1371. Now even you can deploy trained models to production in a matter of minutes.
At Periodic Labs we build labs that learn. Our team recognizes that the transition from digital environments to the physical world is highly complex and unpredictable.
The next breakthroughs in science are deeply coupled with intelligence that is given the opportunity to explore through experimentation.
I've been thrilled and honored to help contribute to the product surface areas that help theorists, experimentalists and industry practitioners in the physical sciences accelerate their goals.
Here's a preview of the scientific and technological progress we've made in closing the experimental loop for XRD analysis using Neon our post-trained 1T model.
We’ve spent the past year building high-throughput labs and infrastructure for large-scale physics experiments in our search for better superconductors and magnets.
We ran our first experiments by hand. Now, experiments run continuously in the labs. We’re building AI to make sense of what they produce and to determine which experiments to run next.
Mark Huang retweeted
We built high-throughput materials labs in Menlo Park to create a loop between experiments and models. The labs generate fresh data, the models learn from it, and then help us decide what to try next.
Using only 1,300 H200s, plus months of our experimental data, we mid-trained and RL’d an open-source model to surpass GPT-6 Astra on our analysis benchmark. We call it Neon.
This is real footage from our lab. We’re focusing first on hard problems in materials science, including superconductors, magnets, and semiconductor materials.
Read our blog posts below.
Had the honor of working with @feilsystem in the past and if I know one thing about him it’s that he likes to go FAST
Our engineers just shipped the fastest named entity recognition (NER) inference on the market: 1 ms P50 and 3 ms P99 server-side latency, 7.7x faster than an optimized PyTorch baseline.
The bottleneck in fast NER is rarely the model: it's tokenization, HTTP parsing, networking, and other overhead.
We solved for that and added it to Baseten Embeddings Inference (BEI). Just point it at your model checkpoint, no model changes needed.
Everyone should be pressure testing skills and treating it as a craft.
Performance folks should follow @feilsystem he knows a thing or two about inference
tldr: We open-source a inference engine that deduplicates prefill tokens and wrote a paper (@juliuslipp).
RadixMLP was missed chance by the community that developed varlen (THD-packed) inference, and overlooked by people working on training and inference engines.
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I continue to believe the fundamental problem of calibration will be a moving target correlated with the broader economic diffusion of AI. People will want clarification more often build trust then require less as we steer models and models steer us?
Replying to @AnthropicAI
Claude Code also encourages oversight by stopping to ask questions.
On complex tasks, Claude Code pauses for clarification more than twice as often as humans interrupt it. Training models to recognize uncertainty is an important, under-appreciated safety property.
Mark Huang retweeted
Airtable gets into the AI agent game with Superagent techcrunch.com/2026/01/27/ai…
Stop talking to a wall of predictive text and start doing real research.
Introducing @Superagent: built to turn your complex business questions into boardroom-ready answers, beautifully rendered as reports, slides, or websites.
Try it: bit.ly/466oEH3
Replying to @superagent
@DeepSkyAI is joining @airtable !
When @chrisatdeepsky , @gradient__f , and I started DeepSky, we had one ambitious goal: build an AI superagent that could handle the cognitively demanding parts of knowledge work—research, strategy, planning.
Massive thanks to our team for building something genuinely hard and shipping at a ridiculous pace. And to our investors—, @mdgarratt , @chriszeoli, @preet1rathi and the entire crew—thanks for backing the vision when it was still mostly conviction and a Figma file.
Mark Huang retweeted
News: Airtable has hired a new CTO away from OpenAI's ChatGPT unit and made its largest startup acquisition to date: 'superagent' builder DeepSky.
CEO Howie Liu and new hire exec David Azose spoke to Upstarts exclusively about what the big moves mean for Airtable's AI strategy.
We had our own business journey in fine tuning back in 2023. Regardless I’m really happy to see @thinkymachines create something I always wished existed.
Introducing Tinker: a flexible API for fine-tuning language models.
Write training loops in Python on your laptop; we'll run them on distributed GPUs.
Private beta starts today. We can't wait to see what researchers and developers build with cutting-edge open models!
thinkingmachines.ai/tinker
Podcast was refreshing and honest. I agree strongly with:
- Build just enough scaffolding to tear it out (bitter lesson pilled)
- Choose to build for one set of users that "want the agent to win"
- No more triangle shape you're expected to build, design and work with users
🆕 Building the God Coding Agent
youtu.be/b4rOVZWLW6E
@AmpCode has been popping up all over the timeline. @sqs and @thorstenball joined the pod to discuss:
- IDE extension vs TUI for coding agents
- How they ship 15x/day
- Why subagents are overrated
- The diminishing importance of model selectors
- The evolution of the SDLC
And many more hot takes on the state of AI coding adoption 👀



















