Matteo Sepulcri (@mat_sepu) header
Matteo Sepulcri (@mat_sepu) profile picture

Radiation Oncologist, main focus on prostate and lung. Basketball lover. #radonc

Padua, Veneto
Joined September 2019
Photo by Matteo Sepulcri (@mat_sepu)
Does nodal irradiation explain the negative results of concurrent Chemo-ICI-RT observed in Pacific-2 and Checkmate 73L? Better a 'perioperative like' strategy Chemo-ICI ->ChemoRT->ICI? Novel scenarios for unresectable stage III NSCLC discussed by @AntonioNuccio01 and @mat_sepu
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Fully published @JTOonline our individual patient data meta-analysis on EFS in pts w/ resectable NSCLC treated w/ neoadj Chemo-IO. An effort led by @dmarinelli93 @AntonioNuccio01 @filippog92 on behalf of a young Italian multidisciplinary oncology group bit.ly/3YO1iCU 1/4
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Matteo Sepulcri retweeted
Individual patient data meta-analysis @JTOonline of neoadjuvant or perioperative trials in resectable NSCLC shows pCR or MPR with neoadjuvant chemo-immunotherapy associated with improved EFS, similar with or without adjuvant immunotherapy component. jto.org/article/S1556-0864(2…
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Matteo Sepulcri retweeted
Sala gremita a Castelfranco Veneto durante i lavori del 2° giorno di 'Advanced Uro-Oncology'. Un evento dedicato ad oncologi, urologi e radioterapisti con Resp. Scientifici Dott. Marco Maruzzo, Prof. Angelo Porreca, Dott. Matteo Sepulcri. @therealmarcodoc @PorrecaAngelo @mat_sepu
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Grande successo per la 2° edizione del congresso ‘Advanced Uro-Oncology’ a Castelfranco Veneto. Responsabili Scientifici: Dott. Marco Maruzzo, Prof. Angelo Porreca, Dott. Matteo Sepulcri. @therealmarcodoc @PorrecaAngelo @mat_sepu #Oncologia #Urologia #Radioterapia
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A partire da domani 18 e 19 aprile a Castelfranco Veneto (TV) Advanced Uro-Oncology Days Responsabili Scientifici Dott.ri Marco Maruzzo, Angelo Porreca, Matteo Sepulcri. @therealmarcodoc @mat_sepu Programma ed iscrizioni: overgroup.eu/evento/advanced…
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LUNG-ART trial out in @TheLancetOncol: bit.ly/3J3ZNH1 Postoperative #radiotherapy in IIIA pN2 NSCLC pts - no increase in DFS (HR 0.86, p=0.18) or OS - increase in late G3/4 cardiopulm tox Negative results but huge work by Dr Cécile Le Péchoux from @GustaveRoussy #lcsm
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Metabolic features can predict response to radical RT for prostate cancer! #PCSM Happy to share our latest work with many thanks to all colleagues and friends @lauraevangelis9 @MarcoFusella doi.org/10.1016/j.ctro.2021.…
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Matteo Sepulcri retweeted
So proud to present our Guidelines for Radiotherapy of Bladder Cancer ➡️ GETUG-AFU Recommendations for planning and delivery of radical radiotherapy for ... sciencedirect.com/science/ar… – at Bordeaux, France
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Updated meta-analysis of PORT for completely resected Masaoka stage II/III Thymoma ☑️ n=4746 pts ⬆️ OS with HR=0.68 ⬆️ Similar beneficial effect in stage II and III #radonc jto.org/article/S1556-0864(2…
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Matteo Sepulcri retweeted
Prospective single arm phase II trial of SBRT for oligometastatic NSCLC ➡️ SBRT was delivered after 2-4 mo systemic Tx ➡️ About 40% were treated with TKI ➡️ Sig. improved PFS for pts with complete metabolic response (median 54 mo) ➡️ No G4 tox #radonc lungcancerjournal.info/artic…
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Delighted to present updated data from the PACIFIC trial in unresectable Stage III NSCLC @myESMO Durable benefit with durvalumab @4 years - almost 50% of patients alive - MS reached for the first time and is an unprecedented 47.5 months =major benefit for patients @MCRCnews
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Our recently completed meta-analysis comparing conventional RT to SRS for management of spinal metastases just published in the Green Journal! @EricLehrer @NicholasZaorsky @DanTrifMD sciencedirect.com/science/ar…
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Red Journal: Article in Press! Patterns of Recurrence and Modes of Progression Following Metastasis Directed Therapy in Oligometastatic Castration Sensitive Prostate Cancer Deek et al. doi.org/10.1016/j.ijrobp.202….
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Final Analysis of the Ipilimumab Versus Placebo Following Radiotherapy Phase III Trial in Postdocetaxel mCRPC Identifies an Excess of Long-term Survivors #VisualAbstract @AlbertoBossial @HouedeNadine @neerajaiims buff.ly/3awcpWw
ESTRO-ACROP guidelines for Target Volume Definition in #SCLC: -Consider clusters of smaller LNs with SAD < 1 cm. -Consider ipsi SCV if level 2 or 3a involved. -CTV = GTV + 5 mm, particularly in CC direction for nodes. -No adaptive nodal cone-down. #radonc pubmed.ncbi.nlm.nih.gov/3267…
Our paper on the effect of radiotherapy-related lymphopenia on overall survival in patients with lung cancer utilizing image-based data mining is now published online in @JTOonline doi.org/10.1016/j.jtho.2020.… @AzadehAbravan @RT_physics @MCRCnews
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Meta-analysis of radiotherapy for prostate cancer: 8 weeks (conventional fractionation) vs 5 weeks (hypofractionation) vs ~1 week (ultra-hypofractionation) of treatment @EricLehrer @AmarUKishan @jamesbyu @DanTrifMD @TimShowalter1 @OncologyAdvance #pcsm #RadOnc
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ASCO abstract: Randomised phase II trial suggests pts with LD SCLC might benefit from higher dose of thoracic RT (60Gy in 40Fx BID) compared to standard dose (45Gy in 30Fx BID); median OS 42mo vs 23mo (HR 0.63) #radonc meetinglibrary.asco.org/reco…
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